A prospective randomized double blind controlled trial including 90 ASA I & II patients between age 18 – 65 yrs for elective arthroscopic anterior cruciate ligament reconstruction surgery divided into 3 groups Group A Clonidine plus Bupivacaine, Group B Dexmedetomidine plus Bupivacaine and Group C Dexamethasone and Bupivacaine. The study compares the effects of clonidine, dexmedetomidine and dexamethasone as an adjuvant to bupivacaine in arthroscopic anterior cruciate ligament reconstruction surgeries in postoperative period for 24 hrs after ultrasound and peripheral nerve stimulation guided femoral nerve block and thus concluding which drug combination produces better analgesia with minimal haemodynamic alterations. 

Finding summary: Addition of Dexamethasone to local anesthetic drugs in femoral block significantly prolongs the onset and duration of analgesia, sensory and motor block as compared to clonidine and dexmedetomidine in patients undergoing ACL reconstruction surgeries. Dexamethasone as an additive provides: Better pain relief, prolongation of post operative analgesia and, decrease consumption of systemic analgesics in post operative period with manageable hemodynamic alterations. It is a remarkably, safe and cost effective method of providing postoperative analgesia. US-guided brachial plexus block technique has several advantages including faster onset and greater block success.