In India there is high prevalence of type 2 Diabetes mellitus. Between 20-79 years of population 66.8 million people are living with type 2 Diabetes. Diabetes national prevalence in India is 8.63%. A study conducted to evaluate the hand functioning in patients with diabetes and its impact on quality of life (QoL) in the physical and mental dimensions suggested that impaired hand function affects lower acceptance of the disease, the occurrence of depression and reduced patient’s QoL. Studies have also shown that there is a high prevalence of upper limb and hand dysfunction in patients with type 2 Diabetes mellitus in India. South Indian postmenopausal osteoporosis women perform lesser physical activity compared to European women. It is well known from the literature that there is high prevalence of osteoporosis in postmenopausal women and also in women with type 2 diabetes mellitus in India. There is bone architectural changes and also bone loading changes are associated with type 2 diabetes. South Indian women with type 2 Diabetes mellitus had lesser bone mineral density compared to normal women. The current study focuses on estimation of prevalence of upper limb dysfunction and hand function in postmenopausal women with osteoporosis with type 2 Diabetes mellitus. Effect of upper limb and hand dysfunction on hand function and QoL will be measured. Effect of structured exercise based rehabilitation program on the hand function and QoL will be evaluated. If the participants improve with the intervention, structured exercises can be incorporated as part of  treatment while treating type 2 diabetes mellitus with postmenopausal osteoporosis