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CTRI Number  CTRI/2026/02/104229 [Registered on: 18/02/2026] Trial Registered Prospectively
Last Modified On: 12/02/2026
Post Graduate Thesis  Yes 
Type of Trial  Interventional 
Type of Study   Drug
Ayurveda 
Study Design  Randomized, Parallel Group Trial 
Public Title of Study   A Clinical Study To Evaluate The Efficacy Of Aragvadhadi Kwath Yonidhavan In Kaphaj Yonivyapad With Special Reference To Vulvovaginal Candidiasis 
Scientific Title of Study   An Open Randomized Control Clinical Trial TO Evaluate The Efficacy Of Aragvadhadi Kwath Yonidhavan In Kaphaj Yonivyapad With Special Reference To Vulvovaginal Candidiasis 
Trial Acronym  NIL 
Secondary IDs if Any  
Secondary ID  Identifier 
NIL  NIL 
 
Details of Principal Investigator or overall Trial Coordinator (multi-center study)  
Name  Dr Rahila Nawsheen Afsar Khan 
Designation  PG Scholar 
Affiliation  Hon Shri Annasaheb Dange Ayurved Medical College Post Graduate and Research Centre Ashta 
Address  Department of Prasuti Tantra evum striroga Hon Shri Annasaheb Dange Ayurved Medical College Post Graduate and Research Centre Ashta Tal Walwa Dist Sangli 416301

Sangli
MAHARASHTRA
416301
India 
Phone  9518734967  
Fax    
Email  rahilakhan1816@gmail.com  
 
Details of Contact Person
Scientific Query  
Name  Dr Dilip Vitthal Katare 
Designation  Professor Department of Prasuti Tantra evum Striroga 
Affiliation  Hon Shri Annasaheb Dange Ayurved Medical College Post Graduate and Research Centre Ashta 
Address  Department of Prasuti Tantra evum striroga Hon Shri Annasaheb Dange Ayurved Medical College Post Graduate and Research Centre Ashta Tal Walwa Dist Sangli 416301

Sangli
MAHARASHTRA
416301
India 
Phone  9881215521  
Fax    
Email  drdilipkatareashta@gmail.com  
 
Details of Contact Person
Public Query  
Name  Dr Dilip Vitthal Katare 
Designation  Professor Department of Prasuti Tantra evum Striroga 
Affiliation  Hon Shri Annasaheb Dange Ayurved Medical College Post Graduate and Research Centre Ashta 
Address  Department of Prasuti Tantra evum striroga Hon Shri Annasaheb Dange Ayurved Medical College Post Graduate and Research Centre Ashta Tal Walwa Dist Sangli 416301

Sangli
MAHARASHTRA
416301
India 
Phone  9881215521  
Fax    
Email  drdilipkatareashta@gmail.com  
 
Source of Monetary or Material Support  
Hon Shri Annasaheb Dange Ayurved Medical College Post Graduate and Research Centre A/P Ashta Tal walwa Dist Sangli Maharashtra 416301 
 
Primary Sponsor  
Name  Dr Rahila Nawsheen Afsar Khan  
Address  Department of Prasuti tantra evum Striroga OPD No 6 Hon Shri Annasaheb Dange Ayurved Medical College Post Graduate and Research Centre A/P Ashta Tal walwa Dist Sangli Maharashtra 416301 
Type of Sponsor  Other [Self] 
 
Details of Secondary Sponsor  
Name  Address 
NIL  NIL 
 
Countries of Recruitment     India  
Sites of Study  
No of Sites = 1  
Name of Principal Investigator  Name of Site  Site Address  Phone/Fax/Email 
Dr Rahila Nawsheen Afsar Khan  Hon Shri Annasaheb Dange Ayurved Medical College Post Graduate and Research Centre Ashta   Department of Prasuti Tantra evum striroga OPD No 6 Dhanwantari Hospital Hon Shri Annasaheb Dange Ayurved Medical College Post Graduate and Research Centre Ashta Tal Walwa Dist Sangli 416301
Sangli
MAHARASHTRA 		 9518734967

rahilakhan1816@gmail.com 
 
Details of Ethics Committee  
No of Ethics Committees= 1  
Name of Committee  Approval Status 
Institutional Ethical Committee of Hon Shri Annasaheb Dange Ayurved Medical College Post Graduate and Research Centre Ashta Sangli  Approved 
 
Regulatory Clearance Status from DCGI  
Status 
Not Applicable 
 
Health Condition / Problems Studied  
Health Type  Condition 
Patients  (1) ICD-10 Condition:N771||Vaginitis, vulvitis and vulvovaginitis in diseases classified elsewhere. Ayurveda Condition: KAPAJA-YONIROGAH, (2) ICD-10 Condition:N771||Vaginitis, vulvitis and vulvovaginitis in diseases classified elsewhere. Ayurveda Condition: YONIROGAH/YONI-VYAPADAH,  
 
Intervention / Comparator Agent  
snoIntervention/ComparatorTypeDrug-TypeProcedure NameDetails
1Intervention ArmProcedure-yoni dhAvana, योनि धावन (Procedure Reference: Ashtang Hriday Uttarsthan 34/57 , Procedure details: Aragvadh-Nimba-Karanja Kwath Yonidhawan on 6th day of menses. Follow up on 1st , 3rd , 7th Day during treatment & 15th Day (after treatment) )
(1) Medicine Name: Aargavadh nimb karanj Kwath, Reference: Ashtang Hriday Sutrasthan 15/17-18, Route: Vaginal, Dosage Form: Kwatha/Kashaya, Dose: 1000(ml), Frequency: od, Duration: 7 Days
2Comparator ArmDrugOther than Classical(1) Medicine Name: Clotrimazole Pessary, Reference: NA, Route: Vaginal, Dosage Form: Varti/ Suppository, Dose: 100(mg), Frequency: hs, Bhaishajya Kal: , Duration: , anupAna/sahapAna: No, Additional Information:
(2) Medicine Name: 7 Days, Reference: NA, Route: -, Dosage Form: Varti/ Suppository, Dose: (), Frequency: , Bhaishajya Kal: , Duration: , anupAna/sahapAna: No, Additional Information:
 
Inclusion Criteria  
Age From  20.00 Year(s)
Age To  50.00 Year(s)
Gender  Female 
Details  1. Married Patients having Kaphaj Yonivyapad i.e
having following signs and symptoms
2. Yonigata shweta picchil strav, Yoni kandu
Yonigat alpavedana
3. Patient selection of vaginal candidiasis will be
confirmed after doing KOH Test 
 
ExclusionCriteria 
Details  1. Unmarried female patients.
2. Known cases of sexually transmitted diseases.
3. Uncontrolled DM & HTN.
4. Pregnant women.
5. Cervical polyp and cervical erosion.
6. Patients with intolerable severe pain (VAS
scale of 8 to 10) will be excluded.  
 
Method of Generating Random Sequence   Coin toss, Lottery, toss of dice, shuffling cards etc 
Method of Concealment   Case Record Numbers 
Blinding/Masking   Open Label 
Primary Outcome  
Outcome  TimePoints 
Aragvadhadi kwath yonidhavan is effective in Kaphaj Yonivyapad w.s.r.to VulvoVaginal candidiasis.   7 days 
 
Secondary Outcome  
Outcome  TimePoints 
1. Aragvadhadi kwath yonidhavan for 7 days increases pH of vagina  Follow up 1st 3rd 7th day during treatment  
 
Target Sample Size   Total Sample Size="64"
Sample Size from India="64" 
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" 
Phase of Trial   Phase 2/ Phase 3 
Date of First Enrollment (India)   01/04/2026 
Date of Study Completion (India) Applicable only for Completed/Terminated trials 
Date of First Enrollment (Global)  Date Missing 
Date of Study Completion (Global) Applicable only for Completed/Terminated trials 
Estimated Duration of Trial   Years="1"
Months="6"
Days="0" 
Recruitment Status of Trial (Global)   Not Yet Recruiting 
Recruitment Status of Trial (India)  Not Yet Recruiting 
Publication Details   N/A 
Individual Participant Data (IPD) Sharing Statement

Will individual participant data (IPD) be shared publicly (including data dictionaries)?  

Response - NO
Brief Summary  

In Ayurveda, a dedicated section on women’s health uses the term Yoni vyapad to encompass most gynecological disorder. 20 Yonirogas (Vinshati Yonivyapad) described in Ayurveda samhita by different Acharyas. Kaphaj Yonivyapad is one among them having Yonigata Shwetstrav, Yoni kandu and alpa yonivedana as Pradhan lakshan.

Vulvovaginal candidiasis (VVC), one of the most widespread fungal infections among women of reproductive age, is most often caused by Candida albicans. In India, an estimated 30% of women have vaginal candidiasis. It is characterized by symptoms like vaginal itching, white curd-like discharge, erythema and discomfort, significantly impacting the quality of life. Most antifungal regimen treatments are available for vaginal candidiasis can but have chance of side effects as well as recurrences.

The drug Aragvadha, Nimb & karanj having properties Kaphashamak, Kandughana, Krimighana, Stambhak Vranaropak, Antiseptic. Because of these properties it helps to overcome the symptoms of Kaphaj Yonivyapad by increasing local immunity and prevent recurrence of symptoms in patients.

 
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