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CTRI Number  CTRI/2026/02/103706 [Registered on: 12/02/2026] Trial Registered Prospectively
Last Modified On: 11/02/2026
Post Graduate Thesis  Yes 
Type of Trial  Interventional 
Type of Study   Drug
Ayurveda
Preventive 
Study Design  Randomized, Parallel Group Trial 
Public Title of Study   A comparative clinical study to evaluate the added effect of haridra and sphatika pichu with nagkeshar churna and takra in the treatment of Shwet Pradara leucorrhea  
Scientific Title of Study   A Randomized Comparative clinical study to evaluate an add-on effect of Haridra and Sphatika (alum) pichu with nagkeshar churna and takra in the management of Shwet Pradara (leucorrhea). 
Trial Acronym  NIL 
Secondary IDs if Any  
Secondary ID  Identifier 
NIL  NIL 
 
Details of Principal Investigator or overall Trial Coordinator (multi-center study)  
Name  Dr Sakshi Devang 
Designation  PG Scholar 
Affiliation  PDEAs College of Ayurved and Research Centre,Nigdi ,Pune 
Address  PDEAs College of Ayurved and Research Centre,Nigdi,Pune

Nashik
MAHARASHTRA
411044
India 
Phone  7756063721  
Fax    
Email  devangsd2000@gmail.com  
 
Details of Contact Person
Scientific Query  
Name  Dr Anjali Jadhav 
Designation  Professor and HOD 
Affiliation  PDEAs College of Ayurved and Research Centre,Nigdi,Pune 
Address  PDEAs College of Ayurved and Research Centre,Nigdi,Pune

Pune
MAHARASHTRA
411044
India 
Phone  9850808899  
Fax    
Email  anjalivijayjadhav@gmail.com  
 
Details of Contact Person
Public Query  
Name  Dr Anjali Jadhav 
Designation  Professor and HOD 
Affiliation  PDEAs College of Ayurved and Research Centre,Nigdi,Pune 
Address  PDEAs College of Ayurved and Research Centre,Nigdi,Pune

Pune
MAHARASHTRA
411044
India 
Phone  9850808899  
Fax    
Email  anjalivijayjadhav@gmail.com  
 
Source of Monetary or Material Support  
PDEAs College of Ayurveda and Research Centre, Sector 25, Pradhikaran ,Nigdi ,Pune 411044 
 
Primary Sponsor  
Name  PDEAs College of Ayurveda and Research Centre, Nigdi Pune 
Address  PDEAs College of Ayurveda and Research Centre, Streerog department,Nigdi Pune MAHARASHTRA 411044 India 
Type of Sponsor  Private medical college 
 
Details of Secondary Sponsor  
Name  Address 
NIL  NIL 
 
Countries of Recruitment     India  
Sites of Study  
No of Sites = 1  
Name of Principal Investigator  Name of Site  Site Address  Phone/Fax/Email 
Dr Sakshi Devang  Ayurveda Rugnalay and Sterling Multispeciality Hospital Nigdi, Pradhikaran, Pune  Ayurveda Rugnalay and sterling multispeciality hospital Nigdi Pradhikaran Pune sector 27 Streerog Department OPD NO 119 Pune
Pune
MAHARASHTRA 		 7756063721

devangsd2000@gmail.com 
 
Details of Ethics Committee  
No of Ethics Committees= 1  
Name of Committee  Approval Status 
Chairperson Institutional Ethics Committeee  Approved 
 
Regulatory Clearance Status from DCGI  
Status 
Not Applicable 
 
Health Condition / Problems Studied  
Health Type  Condition 
Patients  (1) ICD-10 Condition:N899||Noninflammatory disorder of vagina, unspecified. Ayurveda Condition: YONIROGAH/YONI-VYAPADAH,  
 
Intervention / Comparator Agent  
snoIntervention/ComparatorTypeDrug-TypeProcedure NameDetails
1Comparator ArmDrugClassical(1) Medicine Name: nagkeshar churna, Reference: bhavaprakash chikitsa 69, Route: Oral, Dosage Form: Churna/ Powder, Dose: 3(g), Frequency: bd, Bhaishajya Kal: Adhobhakta, Duration: 7 Days, anupAna/sahapAna: Yes(details: -takra), Additional Information: -
2Intervention ArmDrugClassical(1) Medicine Name: nagkeshar churna, Reference: bhavprakash chikitsa sthan 69/11, Route: Oral, Dosage Form: Churna/ Powder, Dose: 3(g), Frequency: bd, Bhaishajya Kal: Adhobhakta, Duration: 7 Days, anupAna/sahapAna: Yes(details: -takra), Additional Information: -
3Intervention ArmProcedure-yoni picu, योनि पिचु (Procedure Reference: charak chikitsa 30, Procedure details: Procedure details: Sterile speculum inserted in the vagina . medicated pichu placed inside vagina under aseptic precautions . Ensure proper placement near cervical canal. Pichu kept inside vagina for approximately 3 hours daily for 7 days.))
(1) Medicine Name: haridra, Reference: dhanvantari nighantu 55, Route: Vaginal, Dosage Form: Churna/ Powder, Dose: 1(g), Frequency: od, Duration: 7 Days
(2) Medicine Name: sphatik, Reference: raj nighantu 118, Route: Vaginal, Dosage Form: Churna/ Powder, Dose: 1(g), Frequency: od, Duration: 7 Days
 
Inclusion Criteria  
Age From  19.00 Year(s)
Age To  45.00 Year(s)
Gender  Female 
Details  Married patient of age group 19-45 who are having c/o yonigata shwetastrava(white vaginal discharge) 
 
ExclusionCriteria 
Details  1. Pregnant women
Known case of-
2. Cervical or uterine malignancy
3. Human immunodeficiency viruses
4. Sexually transmitted diseases
5. Uterine fibroid
6. Uterine polyp

 
 
Method of Generating Random Sequence   Coin toss, Lottery, toss of dice, shuffling cards etc 
Method of Concealment   Alternation 
Blinding/Masking   Open Label 
Primary Outcome  
Outcome  TimePoints 
To compare the efficacy of Haridra and Turti Pichu as an add on therapy to Nagkeshar Churna and Takra in reducing vaginal discharge, itching, discomfort in patients with Shweta Pradara in time duration of 30 days.

 		 To compare the efficacy of Haridra and Turti Pichu as an add on therapy to Nagkeshar Churna and Takra in reducing vaginal discharge, itching, discomfort in patients with Shweta Pradara in time duration of 30 days.

 
 
Secondary Outcome  
Outcome  TimePoints 
To observe & compare the adverse effect within 30 days if any  30 days treatment 
 
Target Sample Size   Total Sample Size="35"
Sample Size from India="35" 
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" 
Phase of Trial   N/A 
Date of First Enrollment (India)   25/02/2026 
Date of Study Completion (India) Applicable only for Completed/Terminated trials 
Date of First Enrollment (Global)  Date Missing 
Date of Study Completion (Global) Applicable only for Completed/Terminated trials 
Estimated Duration of Trial   Years="1"
Months="6"
Days="0" 
Recruitment Status of Trial (Global)   Not Applicable 
Recruitment Status of Trial (India)  Not Yet Recruiting 
Publication Details   N/A 
Individual Participant Data (IPD) Sharing Statement

Will individual participant data (IPD) be shared publicly (including data dictionaries)?  

Response - NO
Brief Summary  
This study aims to evaluate the add on effect of Haridra and Sphatika pichu with Nagkeshar churna and takra in the management of Shwet Pradara which is comparable to leucorrhea. Shwet Pradara is a common gynecological complaint in women of reproductive age characterized by excessive white vaginal discharge and is mainly associated with vitiation of Kapha dosha. Conventional treatment provides temporary relief and recurrence is common therefore there is a need for safe and effective Ayurvedic management.

The study is designed as a randomized comparative clinical trial including seventy patients suffering from Shwet Pradara. Patients will be divided into two groups. Group A will receive Nagkeshar churna with takra orally. Group B will receive Nagkeshar churna with takra along with Haridra and Sphatika pichu as local therapy. Treatment duration will be seven days with follow up on fifteenth and thirteeth day.

The objective of the study is to compare the effectiveness of combined internal and external Ayurvedic therapy in reducing symptoms such as vaginal discharge itching burning micturition and lower backache. The study also aims to observe any adverse effects and evaluate overall improvement.

Assessment will be done using subjective and objective clinical parameters. Statistical analysis will be performed to compare the results between both groups. This study is expected to provide clinical evidence for a holistic Ayurvedic approach in the management of Shwet Pradara and help in reducing recurrence and improving quality of life in affected women.

 
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