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CTRI Number  CTRI/2026/02/103244 [Registered on: 06/02/2026] Trial Registered Prospectively
Last Modified On: 06/02/2026
Post Graduate Thesis  Yes 
Type of Trial  Interventional 
Type of Study   Homeopathy 
Study Design  Randomized, Parallel Group, Placebo Controlled Trial 
Public Title of Study   Understanding the utility of individualized Homoeopathic medicine in the treatment of Osteoarthritis knee.A clinical study comparing Homoeopathic medicine with placebo. 
Scientific Title of Study   TO EXPLORE THE EFFECTIVENESS OF INDIVIDUALIZED HOMOEOPATHIC MEDICINE VS PLACEBO IN THE MANAGEMENT OF OSTEOARTHRITIS KNEE : A RANDOMIZED PLACEBO CONTROLLED TRIAL 
Trial Acronym  NIL 
Secondary IDs if Any  
Secondary ID  Identifier 
NIL  NIL 
 
Details of Principal Investigator or overall Trial Coordinator (multi-center study)  
Name  DrJasmine Kaur 
Designation  Postgraduate trainee  
Affiliation  State National Homoeopathic Medical College and Hospital Lucknow  
Address  Department of Homoeopathic Materia Medica State National Homoeopathic Medical College and Hospital 1-Viraj khand Gomti Nagar Lucknow UTTAR PRADESH 226010 India

Lucknow
UTTAR PRADESH
226010
India 
Phone  8302493904  
Fax    
Email  jasminekaurrdj@gmail.com  
 
Details of Contact Person
Scientific Query  
Name  DrArchna 
Designation  Lecturer  
Affiliation  State National Homoeopathic Medical College and Hospital Lucknow  
Address  Department of Homoeopathic Materia Medica State National Homoeopathic Medical College and Hospital 1-Viraj khand Gomti Nagar Lucknow UTTAR PRADESH 226010 India

Lucknow
UTTAR PRADESH
226010
India 
Phone  8802630777  
Fax    
Email  archna226010@gmail.com  
 
Details of Contact Person
Public Query  
Name  DrArchna 
Designation  Lecturer  
Affiliation  State National Homoeopathic Medical College and Hospital Lucknow  
Address  Department of Homoeopathic Materia Medica State National Homoeopathic Medical College and Hospital 1-Viraj khand Gomti Nagar Lucknow UTTAR PRADESH 226010 India

Lucknow
UTTAR PRADESH
226010
India 
Phone  8802630777  
Fax    
Email  archna226010@gmail.com  
 
Source of Monetary or Material Support  
Out patient department of State National Homoeopathic Medical College and Hospital 1-viraj khand Gomti Nagar Lucknow UTTARPRADESH 226010 
 
Primary Sponsor  
Name  Dr Jasmine Kaur  
Address  Department of Homoeopathic Materia Medica State National Homoeopathic Medical College and Hospital 1-viraj khand Gomti Nagar Lucknow Uttar Pradesh -226010  
Type of Sponsor  Other [Self] 
 
Details of Secondary Sponsor  
Name  Address 
NIL  NIL 
 
Countries of Recruitment     India  
Sites of Study  
No of Sites = 1  
Name of Principal Investigator  Name of Site  Site Address  Phone/Fax/Email 
Dr Jasmine Kaur  State National Homoeopathic Medical College and Hospital Lucknow  OPD-8 Department of Homoeopatic Materia Medica State National Homoeopathic Medical College and Hospital Lucknow Uttarpradesh
Lucknow
UTTAR PRADESH 		 8302493904

jasminekaurrdj@gmail.com 
 
Details of Ethics Committee  
No of Ethics Committees= 1  
Name of Committee  Approval Status 
Institutional Ethics Committee of State National Homoeopathic Medical College and Hospital Lucknow  Approved 
 
Regulatory Clearance Status from DCGI  
Status 
Not Applicable 
 
Health Condition / Problems Studied  
Health Type  Condition 
Patients  (1) ICD-10 Condition: M179||Osteoarthritis of knee, unspecified,  
 
Intervention / Comparator Agent  
Type  Name  Details 
Intervention  Role of individualised homoeopathic medicine in the management of osteorthritis knee  Randomization: Patients satisfying inclusion and exclusion criteria will be randomized in an allocation ratio of 1:1 into two equal arms. Randomization list for 60 patients will be prepared through an online website. The sample size of 60 patients will be divided into two groups: Group A (Individualized homoeopathic medicine) and Group B (Placebo).A well selected homoeopathic remedy on the basis of case taking,analysis, evaluation ,totality and repertorisation will be carried out as per the homoeopathic principles, will be given to (GROUP A) . They will be prescribed indicated medicine in centesimal potency (4 pills of size 30) , there will be no bias in Groups and medicine will be given as per randomisation. Cases were followed up properly on regular basis in every 15 days or as per need of the patient, and results were assessed on the basis of clinical symptoms, changes in WOMAC score. Outcome will be measured by the primary measure which will be WOMAC score. 
Comparator Agent  Role of placebo in the management of osteorthritis knee.  In a samle size of 60 patients after randomisation Group B will be provided placebo. Group A will be provided individualsed homoeopathic remedy 
 
Inclusion Criteria  
Age From  45.00 Year(s)
Age To  80.00 Year(s)
Gender  Both 
Details  1. Patient who are willing for inclusion in the study and giving consent to
participate and those who are able to come for the further follow-ups.
2. Patients having radiological evidence of Osteoarthritis of Knee joints, based
on American College of Rheumatology (ACR) radiographic diagnostic
criteria. (13)
3. Patients belonging to both sexes.
4. Patient belonging to the age above 45 years. 
 
ExclusionCriteria 
Details  1. Patient unwilling for inclusion in the study and those who are not able to
come for follow-ups.
2. Patients taking treatment from any other systems of medicine for
Osteoarthritis. Patients with known immune-compromised diseases or other
severe systemic illness.
3. Patients with other known auto-immune diseases.
4. Patients with malignancies or other severe systemic illnesses.
5. Pregnant and lactating women.
6. Any other condition requiring emergency or surgical intervention. 
 
Method of Generating Random Sequence   Computer generated randomization 
Method of Concealment   On-site computer system 
Blinding/Masking   Participant Blinded 
Primary Outcome  
Outcome  TimePoints 
To find out whether the individualized homoeopathic medicine are more effective than Placebo
in the management of osteoarthritis knee. 		 30 days 
 
Secondary Outcome  
Outcome  TimePoints 
To evaluate the pain, stiffness & physical functioning of knees in the patients with
osteoarthritis knee using Western Ontario & McMaster Universities Arthritis Index (WOMAC) before & after giving homeopathic medicines. 		 3 months 
 
Target Sample Size   Total Sample Size="60"
Sample Size from India="60" 
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" 
Phase of Trial   N/A 
Date of First Enrollment (India)   17/02/2026 
Date of Study Completion (India) Applicable only for Completed/Terminated trials 
Date of First Enrollment (Global)  Date Missing 
Date of Study Completion (Global) Applicable only for Completed/Terminated trials 
Estimated Duration of Trial   Years="1"
Months="6"
Days="0" 
Recruitment Status of Trial (Global)   Not Applicable 
Recruitment Status of Trial (India)  Not Yet Recruiting 
Publication Details   N/A 
Individual Participant Data (IPD) Sharing Statement

Will individual participant data (IPD) be shared publicly (including data dictionaries)?  

Response - NO
Brief Summary  
Osteoarthritis is a degenerative condition of the cartilage and also known as degenerative joint disease. It is the most common type of arthritis and a leading cause of pain and impairment in older adults. Osteoarthritis is the most common cause of disability in patient population older than 65years. Homoeopathy provides an effective treatment for osteoarthritis knee, through it’s safe and gentle approach by addressing the underlying root cause.This study focuses on internal administration of homoeopathic medicine —comparing individualized homeopathic prescriptions based on totality of symptoms with Placebo . This study anticipates improvements in pain severity and quality of life among patients receiving homoeopathic medicines as reflected by improved scores on the WOMAC criteria.
 
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