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CTRI Number  CTRI/2026/02/103138 [Registered on: 05/02/2026] Trial Registered Prospectively
Last Modified On: 05/02/2026
Post Graduate Thesis  Yes 
Type of Trial  Interventional 
Type of Study   Drug
Ayurveda
Preventive 
Study Design  Randomized, Parallel Group, Active Controlled Trial 
Public Title of Study   A study comparing the Effect of Katutaila and Anutaila Pratimarsha Nasya in Allergic rhinitis in Occupations Exposed to Dust  
Scientific Title of Study   A Randomized clinical study on the efficacy of Katutaila and Anutaila Pratimarsha Nasya in Allergic rhinitis in Occupations exposed to dust 
Trial Acronym  NIL 
Secondary IDs if Any  
Secondary ID  Identifier 
NIL  NIL 
 
Details of Principal Investigator or overall Trial Coordinator (multi-center study)  
Name  Dr Megha G 
Designation  PG Scholar 
Affiliation  Shree Jagadguru Gavisiddeshwara Ayurvedic Medical College and Hospital koppall 
Address  OPD NO 5 Ground floor Department of Swasthavritta Shree Jagadguru Gavisiddeshwara Ayurvedic Medical College and Hospital Koppal Karnataka 583231

Koppal
KARNATAKA
583231
India 
Phone  9611934493  
Fax    
Email  meghagkalal333@gmail.com  
 
Details of Contact Person
Scientific Query
 
Name  Dr Prabhu C Nagalapur 
Designation  Professor 
Affiliation  Shree Jagadguru Gavisiddeshwara Ayurvedic Medical College and Hospital koppal 
Address  OPD NO 5 Ground floor Department of Swasthavritta Shree Jagadguru Gavisiddeshwara Ayurvedic Medical College and Hospital Koppal Karnataka 583231
OPD No 5 Ground floor Department of Swasthavritta Shree Jagadguru Gavisiddeshwara Ayurvedic medical College and Hospital Koppal Karnataka 583231
Koppal
KARNATAKA
583231
India 
Phone  9483315576  
Fax    
Email  asha57dsa@gmail.com  
 
Details of Contact Person
Public Query
 
Name  Dr Somanath 
Designation  Professor 
Affiliation  Shree Jagadguru Gavisiddeshwara Ayurvedic Medical College and Hospital koppal 
Address  OPD NO 5 Ground floor Department of Swasthavritta Shree Jagadguru Gavisiddeshwara Ayurvedic Medical College and Hospital Koppal Karnataka 583231

Koppal
KARNATAKA
583231
India 
Phone  9036199959  
Fax    
Email  dr.somu.the.moon@gmail.com  
 
Source of Monetary or Material Support  
Shree Jagadguru Gavisiddeshwara Ayurvedic Medical College and Hospital Koppal 
 
Primary Sponsor  
Name  Dr Megha g 
Address  OPD No 5 Ground floor Department of Swasthavritta Shree Gavisiddeshwara Ayurvedic Medical College and Hospital Koppal Karnataka 583231 
Type of Sponsor  Other [Self] 
 
Details of Secondary Sponsor  
Name  Address 
NIL  NIL 
 
Countries of Recruitment     India  
Sites of Study  
No of Sites = 1  
Name of Principal Investigator  Name of Site  Site Address  Phone/Fax/Email 
Dr Megha G   Shree Jagadguru Gavisiddeshwara Ayurvedic medical hospital   OPD No 5 Ground floor Department of Swasthavritta Shree Jagadguru Gavisiddeshwara Ayurvedic medical College and hospital Koppal Karnataka 583231
Koppal
KARNATAKA 
9611934493

meghagkalal333@gmail.com 
 
Details of Ethics Committee  
No of Ethics Committees= 1  
Name of Committee  Approval Status 
Institutional Ethical Committee Shree Jagadguru Gavisiddeshwara Ayurvedic Medical College and Hospital Koppal  Approved 
 
Regulatory Clearance Status from DCGI  
Status 
Not Applicable 
 
Health Condition / Problems Studied  
Health Type  Condition 
Patients  (1) ICD-10 Condition:J069||Acute upper respiratory infection,unspecified. Ayurveda Condition: PRATISYAYAH/PINASAH,  
 
Intervention / Comparator Agent  
snoIntervention/ComparatorTypeDrug-TypeProcedure NameDetails
1Intervention ArmProcedure-pratimarSaH, प्रतिमर्श (Procedure Reference: Sushruta chikitsa 40/21, Procedure details: Katu taila pratimarsha nasya instilled in each nostrils)
(1) Medicine Name: Katu taila, Reference: Yogaratnakra purvardha Dinacharya Adhyaya 34-35, Route: Nasal, Dosage Form: Bindu/ Drops/ Spray (Karna/ Nasa/ Netra/ Mukha), Dose: 1(ml), Frequency: od, Duration: 60 Days
2Comparator ArmProcedure-pratimarSaH, प्रतिमर्श (Procedure Reference: Sushruta samhita chikitsasthana 40/21, Procedure details: Anutaila pratimarsha nasya instilled in each nostril)
(1) Medicine Name: Anutaila , Reference: Charaka samhita sutrasthana 5/58-62, Route: Nasal, Dosage Form: Bindu/ Drops/ Spray (Karna/ Nasa/ Netra/ Mukha), Dose: 1(ml), Frequency: od, Duration: 60 Days
 
Inclusion Criteria  
Age From  18.00 Year(s)
Age To  60.00 Year(s)
Gender  Both 
Details  Participants who are regularly exposed to dust due to their occupation
Individuals with history of recurrent Allergic rhinitis
Symptoms including sneezing rhinorrhoea nasal congestion and nasal itching 
 
ExclusionCriteria 
Details  Patients unfit for Nasya
COPD Asthma Pneumonia other infectious respiratory illness
DM HTN and other acute or chronic systemic illness Congenital anomalies structural or anatomical abnormalities of organs of URT
History of nasal surgery
Smokers Tobacco or alcohol users 
 
Method of Generating Random Sequence   Coin toss, Lottery, toss of dice, shuffling cards etc 
Method of Concealment   Sequentially numbered, sealed, opaque envelopes 
Blinding/Masking   Open Label 
Primary Outcome  
Outcome  TimePoints 
Katu taila Pratimarsh nasya would be very effective in reduction of the episodes of Allergic rhinitis in different occupations exposed to dust  120 days 
 
Secondary Outcome  
Outcome  TimePoints 
Reduction in entry of dust particle in the respiratory tract or deposition in the nasal mucosa following Pratimarsha nasya and thus prevent occurrence of Allergic rhinitis  60 Days 
 
Target Sample Size   Total Sample Size="40"
Sample Size from India="40" 
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" 
Phase of Trial   Phase 2 
Date of First Enrollment (India)   30/03/2026 
Date of Study Completion (India) Applicable only for Completed/Terminated trials 
Date of First Enrollment (Global)  Date Missing 
Date of Study Completion (Global) Applicable only for Completed/Terminated trials 
Estimated Duration of Trial   Years="0"
Months="4"
Days="0" 
Recruitment Status of Trial (Global)   Not Applicable 
Recruitment Status of Trial (India)  Not Yet Recruiting 
Publication Details   N/A 
Individual Participant Data (IPD) Sharing Statement

Will individual participant data (IPD) be shared publicly (including data dictionaries)?  

Response - NO
Brief Summary  
Recurrent upper respiratory tract infections are a significant public health concern  particularly among individuals in occupations with high exposure to environmental dust  such as Traffic police  construction workers street vendors sweepers  Studies have shown that continuous inhalation of dust leads to inflammation of the nasal mucosa  impaired mucociliary clearance  and reduced local defense mechanisms As per the American College of Allergy  Asthma and Immunology ACAAI allergic rhinitis has increased 100 percentage in each of the last three decades  According to World Allergy Organisation WAO 400 million persons worldwide have Allergic rhinitis  In India 26 percentage of population suffers from Allergic rhinitis  Current therapeutic modalities for the management of Allergic rhinitis includes  antihistamines decongestants mast cell stabilizers  leukotriene receptor antagonists corticosteroids and anticholinergic agents in oral or topical nasal formulations But all these drugs give only symptomatic relief and none of these are free from adverse effects  Long term corticosteroid use may cause mucosal thinning and systemic side effects  In Ayurveda Pratimarsa Nasya a gentle daily nasal administration of medicated oil is described as a part of Dinacharya to maintain Urdhwajatrugata Bala  protect nasal mucosa and prevent disease onset  Anutaila  is particularly known for its Tridoshaghna  Indriya balaprada properties as the administered drug intranasally enters the nasal cavity through  superior  middle and inferior meatus which further stimulates six sinus openings all through and doshavilayana liquification of doshas is readily seen along with absorption of drug essence to exert the action The Katu taila being Sukshma guna enters the minutest channels of the body and it also get absorbed easily because of Snigdha guna and may also obstruct the entry of dust into the nasal cavity  Due to Ushna veerya of Katu taila it pacifies Vata dosha  Ushna guna of Katu taila also has Viliniam kurvanti  property hence it softens and liquefies the morbid doshas and expel out through Nasya Karma  Regular use of Katu taila promotes smooth functioning of sense organs and lightness in Urdhwajatru  upper region  Vimalendriya  Brings purity to sense organs  Katu taila may be cost effective due its fewer ingredients than Anutaila Hence  there is a need to evaluate simple procedures of Dinacharya through a systematic clinical study and prove its preventive effect This study aims to evaluate the effectiveness of both Anutaila Pratimarsha nasya and Katu taila Pratimarsha nasya in reducing the frequency and duration of Allergic Rhinitis in individuals from different dusty occupational backgrounds
 
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