1. What data in particular will be shared?
   Response - All of the individual participant data collected during the trial, after de-identification.
   


2. What additional supporting information will be shared?
   Response -  Study Protocol
   Response -  Statistical Analysis Plan
   Response - Informed Consent Form
   Response - Clinical Study Report
   Response -  Analytic Code
   
   
3. Who will be able to view these files?
   Response - Anyone
   


4. For what types of analyses will this data be available?
   Response - Any purpose.
   


5. By what mechanism will data be made available?
   Response - Proposals should be directed to [mithunkiran7@gmail.com].
   


6. For how long will this data be available start date provided 07-02-2027 and end date provided 29-02-2032?
   Response - Beginning 3 months and ending 5 years following article publication.
   


7. Any URL or additional information regarding plan/policy for sharing IPD? 
   Additional Information - NIL

One of the leading causes of preventable deaths, especially in low- and middle- income countries is sepsis. Hence, early intervention in treating patients presenting to the Emergency Department with sepsis is crucial in improving patient outcomes. Traditionally, patients’ macro circulatory parameters such as mean arterial pressure (MAP) and heart rate are considered, which may not always reflect tissue perfusion. Patients can have normal blood pressure but may still be experiencing ongoing microcirculatory failure – cryptic shock. 

Recent studies indicate that microcirculatory dysfunction, indicated by impaired capillary refill time, high lactate levels, or changes in doppler indices, may precede hemodynamic failure and organ damage. Despite this, microcirculatory parameters are not commonly utilised in the emergency settings because of easily implementable technology, absence of standardised methods and lack of awareness. This study fills a significant gap by combining point-of-care ultrasound evaluations of microcirculation and overall circulation in the Emergency Department (ED), while linking them to clinical outcomes after 24 hours, 72 hours, and one week. These outcomes include the need for increased vasopressors, renal replacement therapy, and mortality rates. By establishing correlations and identifying the gaps, this research could improve predictions for sepsis and guide evidence-based triage decisions in EDs across the country.