| CTRI Number |
CTRI/2026/02/102811 [Registered on: 02/02/2026] Trial Registered Prospectively |
| Last Modified On: |
02/02/2026 |
| Post Graduate Thesis |
Yes |
| Type of Trial |
Interventional |
|
Type of Study
|
Physiotherapy (Not Including YOGA) |
| Study Design |
Randomized, Parallel Group Trial |
|
Public Title of Study
|
to check effect of exercises of the nerves endings on Pain, walking and functional Activity of Daily life in patients following Total Knee
Replacement |
|
Scientific Title of Study
|
Effect of Proprioceptive Neuromuscular Facilitation Exercises on various activity based outcome Timed up and go
test, Pain, Gait and Activity of Daily life in patients following Total Knee
Replacement: A Randomized Controlled Trial |
| Trial Acronym |
NIL |
|
Secondary IDs if Any
|
| Secondary ID |
Identifier |
| NIL |
NIL |
|
|
Details of Principal Investigator or overall Trial Coordinator (multi-center study)
|
| Name |
Dr Sanket Parekh |
| Designation |
Associate Professor |
| Affiliation |
k m Patel Institute of Physiotherapy |
| Address |
dept no 152 Physiotherapy dept K M Patel Institute of Physiotherapy Shree Krishna Hospital Gokalnagar Karamsad
dept of physiotherapy i.e. K M Patel Institute of Physiotherapy Shree Krishna Hospital Gokalnagar Karamsad
Anand
GUJARAT
388325
India |
| Phone |
09879352362 |
| Fax |
|
| Email |
sanketkp@charutarhealth.org |
|
Details of Contact Person
Scientific Query
|
| Name |
Dr Sanket Parekh |
| Designation |
Associate Professor |
| Affiliation |
k m Patel Institute of Physiotherapy |
| Address |
dept no 152 physiotherapy K M Patel Institute of Physiotherapy Shree Krishna Hospital Gokalnagar Karamsad
dept of physiotherapy no 152 K M Patel Institute of Physiotherapy Shree Krishna Hospital Gokalnagar Karamsad
GUJARAT
388325
India |
| Phone |
09879352362 |
| Fax |
|
| Email |
sanketkp@charutarhealth.org |
|
Details of Contact Person
Public Query
|
| Name |
Dr Sanket Parekh |
| Designation |
Associate Professor |
| Affiliation |
k m Patel Institute of Physiotherapy |
| Address |
K M Patel Institute of Physiotherapy Shree Krishna Hospital Gokalnagar Karamsad
dept no 152 physiotherapy dept K M Patel Institute of Physiotherapy Shree Krishna Hospital Gokalnagar Karamsad
GUJARAT
388325
India |
| Phone |
09879352362 |
| Fax |
|
| Email |
sanketkp@charutarhealth.org |
|
|
Source of Monetary or Material Support
|
| Place of the study will be at K M Patel Institute of Physiotherapy Bhaikaka University Gokalnagar Karamsad 388 325 |
|
|
Primary Sponsor
|
| Name |
No Sponser |
| Address |
No Sponser |
| Type of Sponsor |
Other [NIL] |
|
|
Details of Secondary Sponsor
|
|
|
Countries of Recruitment
|
India |
|
Sites of Study
|
| No of Sites = 1 |
| Name of Principal
Investigator |
Name of Site |
Site Address |
Phone/Fax/Email |
| Dr Nandani Patel |
Dept No 152 K M Patel Institute of Physiotherapy Shree Krishna Hospital Karamsad |
K M Patel Institute of Physiotherapy Bhaikaka UNiversity Karamsad
Anand
GUJARAT |
9638095144
nandanipatel271@gmail.com |
|
|
Details of Ethics Committee
|
| No of Ethics Committees= 1 |
| Name of Committee |
Approval Status |
| Institutional Ethics Committee -2 Bhaikaka University Karamsad |
Approved |
|
|
Regulatory Clearance Status from DCGI
|
|
|
Health Condition / Problems Studied
|
| Health Type |
Condition |
| Patients |
(1) ICD-10 Condition: M958||Other specified acquired deformities of musculoskeletal system, |
|
|
Intervention / Comparator Agent
|
| Type |
Name |
Details |
| Comparator Agent |
conventional exercise that is regular physical therapy including stretching and strengthening exercise |
intervention would of 2 weeks |
| Intervention |
proprioceptive exercise which is used for the strengthening and stretching of the muscles |
pre and post exercise means before intervention then intervention will be of 2 weeks and immediately after the 2 weeks |
|
|
Inclusion Criteria
|
| Age From |
40.00 Year(s) |
| Age To |
60.00 Year(s) |
| Gender |
Both |
| Details |
knee flexion more than degree
pt can walk independently with our ansy support
no cognitive impairment and can follow the instruction
|
|
| ExclusionCriteria |
| Details |
neurological or neuromuscular disorders affecting the knee
Revision TKR
of chronic, disabling back, hip, ankle, or foot pain affecting daily activities |
|
|
Method of Generating Random Sequence
|
Computer generated randomization |
|
Method of Concealment
|
Sequentially numbered, sealed, opaque envelopes |
|
Blinding/Masking
|
Investigator Blinded |
|
Primary Outcome
|
| Outcome |
TimePoints |
| NRS, TUG and KOOS adls |
Pre intervention
post intervention that is immediatly after 2 weeks |
|
|
Secondary Outcome
|
| Outcome |
TimePoints |
| GAit parameters |
Pre intervention
post intervention that is immediatly after 2 weeks |
|
|
Target Sample Size
|
Total Sample Size="54"
Sample Size from India="54"
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" |
|
Phase of Trial
|
N/A |
|
Date of First Enrollment (India)
|
16/02/2026 |
| Date of Study Completion (India) |
Applicable only for Completed/Terminated trials |
| Date of First Enrollment (Global) |
Date Missing |
| Date of Study Completion (Global) |
Applicable only for Completed/Terminated trials |
|
Estimated Duration of Trial
|
Years="1"
Months="0"
Days="0" |
|
Recruitment Status of Trial (Global)
|
Not Yet Recruiting |
| Recruitment Status of Trial (India) |
Not Yet Recruiting |
|
Publication Details
|
N/A |
|
Individual Participant Data (IPD) Sharing Statement
|
Will individual participant data (IPD) be shared publicly (including data dictionaries)?
Response - NO
|
|
Brief Summary
|
there are various exercises which is help full in strnegthening of muscle but special exercises which works on nerves for the strengthening might help to recover faster that is why Current study will hep to understand the effectiveness of the Proprioceptive training in TKR patients |