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CTRI Number  CTRI/2026/02/103422 [Registered on: 09/02/2026] Trial Registered Prospectively
Last Modified On: 09/02/2026
Post Graduate Thesis  Yes 
Type of Trial  Observational 
Type of Study   Cross Sectional Study 
Study Design  Single Arm Study 
Public Title of Study   Use of VExUS score for predicting kidney dysfunction after liver transplantation 
Scientific Title of Study   The correlation between Venous Excess Ultrasound score (VExUS) and acute kidney injury in patients undergoing living related liver transplantation. 
Trial Acronym  Nil 
Secondary IDs if Any  
Secondary ID  Identifier 
NIL  NIL 
 
Details of Principal Investigator or overall Trial Coordinator (multi-center study)  
Name  Sauharda Bikram Karki  
Designation  Clinical Fellow in Liver transplant anesthesia and critical care 
Affiliation  Max super speciality hospital, Saket  
Address  Max super speciality hospital, room no - 3501, 5th floor, Saket(West block), 1, Press enclave Road, Saket, New Delhi

South
DELHI
110017
India 
Phone  9818102268  
Fax    
Email  sauhardak@gmail.com  
 
Details of Contact Person
Scientific Query
 
Name  Suraj Deepak Desai  
Designation  Associate Consultant  
Affiliation  Max super speciality hospital, Saket  
Address  Max super speciality hospital, room no - 3501, 5th floor, Saket(West block), 1, Press enclave Road, Saket, New Delhi

South
DELHI
110017
India 
Phone  9008726991  
Fax    
Email  soorajdesai57@gmail.com  
 
Details of Contact Person
Public Query
 
Name  Sauharda Bikram Karki  
Designation  Clinical Fellow in Liver transplant anesthesia and critical care 
Affiliation  Max super speciality hospital, Saket  
Address  Max super speciality hospital,room no - 3501, 5th floor, Saket(West block), 1, Press enclave Road, Saket, New Delhi

South
DELHI
110017
India 
Phone  9818102268  
Fax    
Email  sauhardak@gmail.com  
 
Source of Monetary or Material Support  
Max Superspeciality Hospital, West block, 1 Press enclave Marg, Saket, New Delhi -110017, India 
 
Primary Sponsor  
Name  Max Superspeciality Hospital, Saket, New Delhi. 
Address  Max Superspeciality Hospital, West block, 2 press enclave Marg, Saket, New Delhi-110017  
Type of Sponsor  Private hospital/clinic 
 
Details of Secondary Sponsor  
Name  Address 
NIL  NIL 
 
Countries of Recruitment     India  
Sites of Study  
No of Sites = 1  
Name of Principal Investigator  Name of Site  Site Address  Phone/Fax/Email 
Sauharda Bikram Karki   Max super speciality hospital   Department of anesthesia and critical care, Centre for Liver and biliary sciences, Room no 3419, LTP ICU 4th floor, West block, 1 press enclave Marg, Saket, New Delhi-110017
South
DELHI 
9818102268

sauhardak@gmail.com 
 
Details of Ethics Committee  
No of Ethics Committees= 1  
Name of Committee  Approval Status 
Max HealthCare Ethics committee  Approved 
 
Regulatory Clearance Status from DCGI  
Status 
Not Applicable 
 
Health Condition / Problems Studied  
Health Type  Condition 
Patients  (1) ICD-10 Condition: K74||Fibrosis and cirrhosis of liver,  
 
Intervention / Comparator Agent  
Type  Name  Details 
Intervention  Nil  Nil 
 
Inclusion Criteria  
Age From  18.00 Year(s)
Age To  99.00 Year(s)
Gender  Both 
Details  Adult Chronic liver disease (CLD) patients undergoing living related liver transplantation. 
 
ExclusionCriteria 
Details  Patients with pre-operative AKI (KDIGO guidelines)
Patients with chronic kidney disease
Patient refusal. 
 
Method of Generating Random Sequence   Not Applicable 
Method of Concealment   Not Applicable 
Blinding/Masking   Not Applicable 
Primary Outcome  
Outcome  TimePoints 
To determine the association between venous congestion as estimated by VEXUS and the occurrence and severity of AKI in the postoperative period in patients undergoing living related liver transplantation.  Post operative days 1,2 & 3 
 
Secondary Outcome  
Outcome  TimePoints 
To determine the association of Renal Resistive Index and AKI in patients undergoing living related liver transplantation.  Post operative days 1,2 & 3 
 
Target Sample Size   Total Sample Size="105"
Sample Size from India="105" 
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" 
Phase of Trial   N/A 
Date of First Enrollment (India)   23/02/2026 
Date of Study Completion (India) Applicable only for Completed/Terminated trials 
Date of First Enrollment (Global)  Date Missing 
Date of Study Completion (Global) Applicable only for Completed/Terminated trials 
Estimated Duration of Trial   Years="0"
Months="6"
Days="0" 
Recruitment Status of Trial (Global)   Not Yet Recruiting 
Recruitment Status of Trial (India)  Not Yet Recruiting 
Publication Details   N/A 
Individual Participant Data (IPD) Sharing Statement

Will individual participant data (IPD) be shared publicly (including data dictionaries)?  

Response - NO
Brief Summary   This is a prospective observational study designed to evaluate the relationship between venous congestion assessed by the Venous Excess Ultrasound score and the development of acute kidney injury in adults undergoing living related liver transplantation. Acute kidney injury is a common postoperative complication after liver transplantation, with reported incidence of about fifty percent within the first seventy two hours, and early identification of contributing factors may help improve outcomes. 

The study will be conducted at Max Superspeciality Hospital Saket over a period of nine months and will include adult patients with chronic liver disease undergoing living related liver transplantation. Patients with preoperative acute kidney injury, chronic kidney disease, or those who refuse consent will be excluded. A total of one hundred and five participants will be enrolled, accounting for expected attrition, based on prior data regarding the diagnostic performance of VExUS for predicting acute kidney injury. 

All enrolled patients see standard preoperative evaluation and intraoperative anesthetic management as per institutional protocol. Postoperatively, patients will be monitored in the liver transplant intensive care unit. Venous Excess Ultrasound assessment will be performed at the bedside on postoperative days one two and three. The assessment includes measurement of inferior vena cava diameter and Doppler evaluation of hepatic vein portal vein and intrarenal venous flow to generate a VExUS grade ranging from zero to three indicating increasing severity of venous congestion. Renal resistive index will also be measured on the same days using Doppler ultrasound. 

Renal function will be assessed daily until postoperative day three using serum creatinine urea estimated glomerular filtration rate and urine output. Acute kidney injury will be diagnosed and staged according to KDIGO criteria. The primary objective is to determine the association between VExUS grade and the occurrence and severity of postoperative acute kidney injury. The secondary objective is to assess the association between renal resistive index and acute kidney injury in this population. 

Data will be analyzed using standard statistical methods to describe patient characteristics and to test associations between VExUS grades renal resistive index and acute kidney injury. Diagnostic performance measures and receiver operating characteristic analyses will be used where appropriate. The study involves no additional risk or cost to participants as all investigations are part of routine clinical care and all data will be handled confidentially in accordance with ethical guidelines. 
 
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