Laparoscopic surgeries are becoming popular due to several postoperative benefits allowing quicker recovery, less tissue damage, avoiding big surgical incision, shorter hospital stay with consequent reduction in health care cost. But anaesthetic management in these patients has become complicated due to cardiopulmonary changes occurring during creation of pneumoperitoneum with CO2 and patient position required for different laparoscopic surgeries. 

Laryngoscopy, tracheal intubation and pneumoperitoneum are associated with sympathetically mediated adverse haemodynamic effect like elevation of arterial pressure, heart rate and decrease in cardiac output which adversely affect the outcome. Dexmedetomidine is selective alpha 2 adrenoceptor agonist. It has central sympatholytic action which helps in providing haemodynamic stability. It also has both analgesic and anaesthetic sparing property and Lignocaine is local anaesthetic has proven effect on attenuating stress response during intubation and extubation, also provides analgesia. Hence, this study was designed to evaluate the effect of Dexmedetomidine and Lignocaine in patient hemodynamics, postoperative analgesia in comparison to fentanyl during laparoscopic cholecystectomy.