CTRI

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CTRI Number

CTRI/2026/04/107995 [Registered on: 09/04/2026] Trial Registered Prospectively

Last Modified On:

08/04/2026

Post Graduate Thesis

Yes

Type of Trial

Interventional

Type of Study

Dentistry

Study Design

Randomized, Parallel Group, Active Controlled Trial

Public Title of Study

A clinical study to evaluate the effectiveness of deep dental cleaning alone and in combination with platelet therapy and light-based therapy in patients with gum disease

Scientific Title of Study

Clinical evaluation of scaling and root planing alone and as an adjunct to injectable platelet-rich fibrin, photobiomodulation and their combined effect in chronic periodontitis - A randomized clinical trial.

Trial Acronym

NIL

Secondary IDs if Any

Secondary ID	Identifier
NIL	NIL

Details of Principal Investigator or overall Trial Coordinator (multi-center study)

Name	Dr Vedantee Pandya
Designation	1 st year post graduate student
Affiliation	College of dental science amargagh bhavnagar
Address	Girls hostel College of dental science amargadh bhavnagar room no. 5 department of periodontology ,College of dental science amargadh bhavnagar Bhavnagar GUJARAT 364210 India
Phone	6356815068
Fax
Email	pandyavedantee@gmail.com

Details of Contact Person
Scientific Query

Name	Dr Jeeth Rai
Designation	Professor of department of periodontology
Affiliation	College of dental science amargadh bhavnagar
Address	room no.5 department of periodontology college of dental science amargadh room no.5 department of periodontology college of dental science amargadh Bhavnagar GUJARAT 364210 India
Phone	9011291375
Fax
Email	jeeth_rai@yahoo.com

Details of Contact Person
Public Query

Name	Dr Jeeth Rai
Designation	Professor of department of periodontology
Affiliation	College of dental science amargadh bhavnagar
Address	room no.5 department of periodontology college of dental science amargadh room no.5 department of periodontology college of dental science amargadh Bhavnagar GUJARAT 364210 India
Phone	9011291375
Fax
Email	jeeth_rai@yahoo.com

Source of Monetary or Material Support

NIL

Primary Sponsor

Name	Dr Vedantee Pandya
Address	room no.5 department of periodontology college of dental science amargadh 364210 bhavnagar gujrat india
Type of Sponsor	Other [self]

Details of Secondary Sponsor

Name	Address
NIL	NIL

Countries of Recruitment

India

Sites of Study

No of Sites = 1
Name of Principal Investigator	Name of Site	Site Address	Phone/Fax/Email
Dr Vedantee Pandya	College of Dental Science and Hospital, Amargadh	room no.5 department of periodontology college of dental science amargadh Bhavnagar GUJARAT	6356815068 - pandyavedantee@gmail.com

Details of Ethics Committee

No of Ethics Committees= 1
Name of Committee	Approval Status
Institutional Ethics Committee, College of Dental Science and Hospital, Amargadh	Approved

Regulatory Clearance Status from DCGI

Status

Not Applicable

Health Condition / Problems Studied

Health Type	Condition
Patients	, (1) ICD-10 Condition: K053\|\|Chronic periodontitis,

Intervention / Comparator Agent

Type	Name	Details
Comparator Agent	SCALING AND ROOT PLANING	SUPRA GINGIVAL SCALING SUBGINGIVAL SCALING ROOT PLANING
Intervention	SRP WITH IPRF	SRP followed by IPRF once
Intervention	SRP With IPRF and PBM	SRP With IPRF once and PBM baseline 3 days and 7 days
Intervention	SRP With PBM	SRP With PBM Baseline 3 days and 7 days

Inclusion Criteria

Age From	30.00 Year(s)
Age To	75.00 Year(s)
Gender	Both
Details	1)Aged between 30 and 75 with chronic periodontitis 2) Subjects having at least 2 teeth in each quadrant with PPD 4-6 mm.

ExclusionCriteria

Details

1) Systemically compromised Patients
2) Pregnant and lactating females
3) Smokers , tobacco chewers
4)Mobile teeth
5)Furcation involvement
6) Patients taking any type of medication that effect mucosal healing
7)Patient who were on any antibiotic therapy since last 6 months
8) Patients who have been treated previously for periodontitis

Method of Generating Random Sequence

Coin toss, Lottery, toss of dice, shuffling cards etc

Method of Concealment

Sequentially numbered, sealed, opaque envelopes

Blinding/Masking

Not Applicable

Primary Outcome

Outcome	TimePoints
Primary Objectives 1.To evaluate and compare the changes in periodontal pocket depth (PPD) and clinical attachment level(CAL).	6 weeks and 3 months

Secondary Outcome

Outcome	TimePoints
1.To evaluate & compare changes in plaque index(PI) & reduction in sulcus bleeding index(SBI) & gingival index(GI).	6 weeks & 3 months

Target Sample Size

Total Sample Size="44"
Sample Size from India="44"
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials"

Phase of Trial

Phase 2

Date of First Enrollment (India)

17/08/2026

Date of Study Completion (India)

Applicable only for Completed/Terminated trials

Date of First Enrollment (Global)

Date Missing

Date of Study Completion (Global)

Applicable only for Completed/Terminated trials

Estimated Duration of Trial

Years="2"
Months="0"
Days="0"

Recruitment Status of Trial (Global)

Not Applicable

Recruitment Status of Trial (India)

Not Yet Recruiting

Publication Details

N/A

Individual Participant Data (IPD) Sharing Statement

Will individual participant data (IPD) be shared publicly (including data dictionaries)?

Response - NO

Brief Summary

This randomized clinical trial will be conducted on 44 sample size with chronic periodontitis, who will be randomly allocated into four groups of 11 patients each to evaluate the clinical effectiveness of scaling and root planing (SRP) alone and in combination with injectable platelet-rich fibrin photobiomodulation therapy and their combined use. Clinical parameters will be recorded at baseline and follow-up and the outcomes will be statistically analyzed to compare the efficacy of the four treatment modalities.