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CTRI Number  CTRI/2026/04/107229 [Registered on: 01/04/2026] Trial Registered Prospectively
Last Modified On: 05/04/2026
Post Graduate Thesis  Yes 
Type of Trial  Interventional 
Type of Study   Physiotherapy (Not Including YOGA) 
Study Design  Randomized, Parallel Group, Multiple Arm Trial 
Public Title of Study   A clinical trial to study the effects of two manual physiotherapy techniques, MFR and MET used with pulmonary rehabilitation in patients with chronic obstructive pulmonary disease 
Scientific Title of Study   comparative effect of Myofascial release therapy versus Muscle energy technique as an adjunct to pulmonary rehabilitation on respiratory mechanics, functional exercise capacity, and quality of life in chronic obstructive pulmonary disease (COPD)- A randomized controlled trial 
Trial Acronym  NIL 
Secondary IDs if Any  
Secondary ID  Identifier 
NIL  NIL 
 
Details of Principal Investigator or overall Trial Coordinator (multi-center study)  
Name  Lakshita Garg 
Designation  MPT Student 
Affiliation  jamia hamdard university 
Address  Room no - 9 Rehabilitation center Jamia Hamdard , hamdard nagar , new delhi- 110062

South West
DELHI
110062
India 
Phone  8076170531  
Fax    
Email  Lakshita182@gmail.com  
 
Details of Contact Person
Scientific Query  
Name  Nahid khan  
Designation  Assistant professor 
Affiliation  jamia hamdard university 
Address  Room no -9 Rehabilitation center Jamia Hamdard , hamdard nagar , new delhi- 110062

South West
DELHI
110062
India 
Phone  9582385008  
Fax    
Email  Nahid0409@jamiahamdard.ac.in  
 
Details of Contact Person
Public Query  
Name  Jyoti Ganai  
Designation  Assistant professor 
Affiliation  jamia hamdard 
Address  Room no - 9 Rehabilitation center Jamia Hamdard , hamdard nagar , new delhi- 110062

South West
DELHI
110062
India 
Phone  9818379267  
Fax    
Email  jyotiganai@jamiahamdard.ac.in  
 
Source of Monetary or Material Support  
Jamia Hamdard, Hamdard Nagar , New Delhi - 110062 
 
Primary Sponsor  
Name  JAMIA HAMDARD 
Address  Jamia Hamdard , Hamdard Nagar, New Delhi -110062 
Type of Sponsor  Other [self - funded ] 
 
Details of Secondary Sponsor  
Name  Address 
NIL  NIL 
 
Countries of Recruitment     India  
Sites of Study  
No of Sites = 1  
Name of Principal Investigator  Name of Site  Site Address  Phone/Fax/Email 
Nahid Khan  Department Of Physiotherapy , Jamia Hamdard , Hmadard Nagar , New Delhi - 110062  ROOM NUMBER 9 , REHABILITATION CENTER , JAMIA HAMDARD , HAMDARD nAGAR , NEW DELHI- 110062
South West
DELHI 		 9582385008

Nahid0409@jamiahamdard.ac.in 
 
Details of Ethics Committee  
No of Ethics Committees= 1  
Name of Committee  Approval Status 
Jamia Hamdard Institutional ethics committee (JHIEC)  Approved 
 
Regulatory Clearance Status from DCGI  
Status 
Not Applicable 
 
Health Condition / Problems Studied  
Health Type  Condition 
Patients  (1) ICD-10 Condition: J449||Chronic obstructive pulmonary disease, unspecified,  
 
Intervention / Comparator Agent  
Type  Name  Details 
Intervention  Group A (MFR) , Group B (MET)  Group A: Myofascial Release Technique (MFR) + Pulmonary Rehabilitation Participants receive myofascial release to the diaphragm, sternocleidomastoid, and scalene muscles in supine lying. Diaphragmatic release is applied below the costal margin using gentle sustained fascial pressure synchronized with slow breathing and prolonged exhalation. SCM and scalene release are performed using sustained manual pressure and breathing coordination, avoiding neurovascular structures. Treatment is provided for 3–5 minutes per muscle group, 4 sessions per week for 4 weeks. Diaphragmatic release is progressed from 5 to 10 deep breaths per set over sessions. All participants also receive standard pulmonary rehabilitation. Group B: Muscle Energy Technique (MET) + Pulmonary Rehabilitation Participants receive MET for the diaphragm, SCM, and scalene muscles in supine position. Gentle isometric contractions (20–30% effort) are performed for 5–10 seconds against therapist resistance, followed by relaxation and passive stretching. Each muscle is treated for 2–4 repetitions per session. Diaphragmatic MET is coordinated with deep breathing for 3–5 minutes. Intervention is given along with standard pulmonary rehabilitation for 4 weeks. 
Comparator Agent  Group C ( Pulmonary Rehabilitation)  Participants receive a structured pulmonary rehabilitation program. Lower-limb endurance training includes walking on treadmill using interval methods, performed four days per week for ten to fifteen minutes per session, beginning at sixty to eighty percent of the average six-minute walk test speed and progressed every one to two weeks as tolerated. Upper-limb endurance training using resistance bands is performed for ten to twenty reps, four days per week. Strength training for upper and lower limbs is conducted four days per week with two to three sets of ten to twenty repetitions using progressive resistance. Breathing retraining, including diaphragmatic breathing, pursed-lip breathing, and segmental breathing, is practiced daily. Flexibility exercises are performed daily. Education, self-management strategies, and psychosocial support are provided weekly. Participants are monitored using the Borg dyspnea scale, heart rate, and oxygen saturation, and exercise is paused if oxygen saturation falls below eighty-eight percent. 
 
Inclusion Criteria  
Age From  40.00 Year(s)
Age To  60.00 Year(s)
Gender  Both 
Details  1 Participants with diagnosed COPD (Stage II-Stage III)
2 Stable medical condition (no exacerbations in the last three month)
3 Willingness to participate in the study
 
 
ExclusionCriteria 
Details  1 History of recent thoracic or abdominal surgery
2 Patients with severe orthopedic problems related to spine, fracture of rib
3 Unstable cardiac condition recent myocardial infarction , cor pulmonale etc.
4 Cognitive impairment preventing study participation
5 Subject participation in yoga, gym activities, and physical fitness training activities
6 Active lung disease which are contraindicated for exercise training , Skin related disorder of upper back and chest
7 Uncontrolled diabetes, uncontrolled hypertension
8 Musculoskeletal disorders affecting movement

 
 
Method of Generating Random Sequence   Other 
Method of Concealment   Alternation 
Blinding/Masking   Participant Blinded 
Primary Outcome  
Outcome  TimePoints 
1.Pulmonary Function Tests: FEV1, FVC, FEV1/FVC RATIO, MVV, PEFR
2.Chest Expansion Measurement 		 baseline , immediate , 2 weeks , 4 weeks  
 
Secondary Outcome  
Outcome  TimePoints 
1.Functional capacity
2.dyspnea
3. quality of life
4.thoracic rotation
 		 baseline , immediate , 2 weeks , 4 weeks  
 
Target Sample Size   Total Sample Size="50"
Sample Size from India="50" 
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" 
Phase of Trial   N/A 
Date of First Enrollment (India)   15/04/2026 
Date of Study Completion (India) Applicable only for Completed/Terminated trials 
Date of First Enrollment (Global)  Date Missing 
Date of Study Completion (Global) Applicable only for Completed/Terminated trials 
Estimated Duration of Trial   Years="0"
Months="3"
Days="0" 
Recruitment Status of Trial (Global)
Modification(s)  		 Not Yet Recruiting 
Recruitment Status of Trial (India)  Open to Recruitment 
Publication Details   N/A 
Individual Participant Data (IPD) Sharing Statement

Will individual participant data (IPD) be shared publicly (including data dictionaries)?  

Response - NO
Brief Summary  
 The present study is an interventional study. The purpose of the study is to compare the effects of myofascial release therapy and muscle energy technique as an adjuncts to pulmonary rehabilitation on respiratory mechanics , functional capacity and quality of life in COPD. Study will be conducted at Jamia Hamdard , Rehabilitation Centre in New Delhi , India. The aim and objectives of the study are to compare the effects of myofascial release therapy and muscle energy technique as an adjuncts to pulmonary rehabilitation , to assess and compare functional exercise capacity between the three groups using the 6- minute walk test ,  quality of life using the St. George ’s Respiratory Questionnaire (SGRQ),  dyspnea severity using the modified Borg scale. The outcome measures are respiratory mechanics , functional exercise capacity , quality of life. 

 
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