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CTRI Number  CTRI/2026/02/102777 [Registered on: 02/02/2026] Trial Registered Prospectively
Last Modified On: 31/01/2026
Post Graduate Thesis  Yes 
Type of Trial  Interventional 
Type of Study   Physiotherapy (Not Including YOGA) 
Study Design  Other 
Public Title of Study   Benefits of a structured exercise program and pain education in knee osteoarthritis patients 
Scientific Title of Study   Effects of Structured Exercise and Pain Neuroscience Education on Pain Qualifiers in Knee Osteoarthritis 
Trial Acronym  nil 
Secondary IDs if Any  
Secondary ID  Identifier 
NIL  NIL 
 
Details of Principal Investigator or overall Trial Coordinator (multi-center study)  
Name  Tejjuas G 
Designation  Postgraduate student 
Affiliation  Sri Ramachandra Institute of Higher Education and Research 
Address  Room No:2.2,second floor, Sri Ramachandra Faculty of physiotherapy, Sri Ramachandra Institute of higher education and Research, Porur, Chennai, Tamil Nadu

Chennai
TAMIL NADU
600116
India 
Phone  7010127258  
Fax    
Email  tejjuasgandhinathan31@gmail.com  
 
Details of Contact Person
Scientific Query
 
Name  AngelineR  
Designation  Assistant Professor 
Affiliation  Sri Ramachandra Institute of Higher Education and Research 
Address  Sri Ramachandra Faculty of physiotherapy, Sri Ramachandra Institute of higher education and Research, Porur, Chennai, Tamil Nadu

Chennai
TAMIL NADU
600116
India 
Phone  9943529400  
Fax    
Email  angelinejobin75@sriramachandra.edu.in  
 
Details of Contact Person
Public Query
 
Name  AngelineR  
Designation  Assistant Professor 
Affiliation  Sri Ramachandra Institute of Higher Education and Research 
Address  Sri Ramachandra Faculty of physiotherapy, Sri Ramachandra Institute of higher education and Research, Porur, Chennai, Tamil Nadu

Chennai
TAMIL NADU
600116
India 
Phone  9943529400  
Fax    
Email  angelinejobin75@sriramachandra.edu.in  
 
Source of Monetary or Material Support  
Sri Ramachandra Institute of Higher Education and Research, New block Physiotherapy OPD , Ground floor, No:1 sri ramachandra nagar , Porur , Chennai,Tamil Nadu, 600116 
 
Primary Sponsor  
Name  Tejjuas G 
Address  No:1 Sri Ramachandra Faculty of Physiotherapy, Sri Ramachandra Institute of Higher Education and Research , Porur, Chennai,Tamil Nadu 600116 
Type of Sponsor  Other [self funded] 
 
Details of Secondary Sponsor  
Name  Address 
NIL  NIL 
 
Countries of Recruitment     India  
Sites of Study  
No of Sites = 1  
Name of Principal Investigator  Name of Site  Site Address  Phone/Fax/Email 
Dr Angeline  sri ramachandra institute of higher education and research  new G block physiotherapy OPD ground floor sri ramachandra hospital sri ramachandra institute of higher education and research porur chennai 600116
Chennai
TAMIL NADU 
9943529400

angelinejobin75@sriramachandra.edu.in 
 
Details of Ethics Committee  
No of Ethics Committees= 1  
Name of Committee  Approval Status 
Ethics Commitee For Students project  Approved 
 
Regulatory Clearance Status from DCGI  
Status 
Not Applicable 
 
Health Condition / Problems Studied  
Health Type  Condition 
Patients  (1) ICD-10 Condition: M859||Disorder of bone density and structure, unspecified,  
 
Intervention / Comparator Agent  
Type  Name  Details 
Comparator Agent  Structured exercise alone  Supervisied structured exercise without pain neuroscience education 
Intervention  Structured exercise with Pain neuroscience education  supervised structure exercise combined with pain neuroscience education 4 weeks 
 
Inclusion Criteria  
Age From  45.00 Year(s)
Age To  75.00 Year(s)
Gender  Both 
Details  Age 45 to 75 years.
Experienced knee pain for at least 3 months
Average knee pain greater than 3/10 on Numeric Pain Rating Scale (NPRS) over the past week
Pain Catastrophizing Scale (PCS) more than 20
 
 
ExclusionCriteria 
Details  Knee surgery in past 6 months or planned in next 3 months
Systemic inflammatory arthritis, oncologic pain, or other red-flag conditions
Neurological diseases affecting lower limb sensation
Intra-articular injection in past 3 months
pregnant women
 
 
Method of Generating Random Sequence   Other 
Method of Concealment    
Blinding/Masking    
Primary Outcome  
Outcome  TimePoints 
SF MPQ sensory subscale
Pain DETECT 
baseline and after 4 weeks 
 
Secondary Outcome  
Outcome  TimePoints 
numerical pain rating scale
Central sensitization inventory
pain catastrophizing scale
Knee injury & osteoarthritis outcome score 
baseline week 0 & end of the intervention week 4 
 
Target Sample Size   Total Sample Size="76"
Sample Size from India="76" 
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" 
Phase of Trial   N/A 
Date of First Enrollment (India)   15/02/2026 
Date of Study Completion (India) Applicable only for Completed/Terminated trials 
Date of First Enrollment (Global)  Date Missing 
Date of Study Completion (Global) Applicable only for Completed/Terminated trials 
Estimated Duration of Trial   Years="0"
Months="1"
Days="0" 
Recruitment Status of Trial (Global)   Not Yet Recruiting 
Recruitment Status of Trial (India)  Not Yet Recruiting 
Publication Details   N/A 
Individual Participant Data (IPD) Sharing Statement

Will individual participant data (IPD) be shared publicly (including data dictionaries)?  

Response - NO
Brief Summary  

Knee osteoarthritis is a common condition that causes long-term knee pain, stiffness, and difficulty in daily activities. Many people with knee osteoarthritis experience different types of pain sensations such as aching, burning, or sharp pain, which can affect their quality of life. Exercise therapy is commonly recommended for managing knee osteoarthritis pain; however, pain education may further improve pain experience by helping individuals better understand and manage their pain.This study aims to compare the effects of a structured exercise program alone and a structured exercise program combined with pain education on pain characteristics in individuals with knee osteoarthritis. Participants will be randomly allocated into two groups. Both groups will receive supervised structured exercises three times per week for four weeks. In addition, one group will receive weekly pain education sessions along with exercise, while the other group will receive exercise alone.Pain characteristics, pain intensity, physical function, and pain-related psychological factors will be assessed before and after the four-week intervention period. The findings of this study may help improve non-surgical management strategies for knee osteoarthritis by identifying whether adding pain education to exercise provides additional benefits in reducing knee pain and improving function.

 
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