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CTRI Number  CTRI/2026/02/102793 [Registered on: 02/02/2026] Trial Registered Prospectively
Last Modified On: 30/01/2026
Post Graduate Thesis  Yes 
Type of Trial  Interventional 
Type of Study   Drug
Ayurveda 
Study Design  Randomized, Parallel Group Trial 
Public Title of Study   Study To Evaluate The Efficacy Of Tiktaka Gritha Tarpana And Eye Exercise In The Management Of Astigmatism Timira 
Scientific Title of Study   An Open Label Double Arm Controlled Clinical Study To Evaluate The Efficacy Of Tiktaka Gritha Tarpana And Eye Exercise In The Management Of Astigmatism Timira 
Trial Acronym  NIL 
Secondary IDs if Any  
Secondary ID  Identifier 
NIL  NIL 
 
Details of Principal Investigator or overall Trial Coordinator (multi-center study)  
Name  Dr Divya T N 
Designation  Pg Scholar 
Affiliation  SDM Institute of Ayurveda Bangalore 
Address  SDM Institute Of Ayurveda And Hospital , Bangalore Anchepalya , Kumbalgodu Post 560074

Bangalore
KARNATAKA
560096
India 
Phone  9113014759  
Fax    
Email  divyatn00437@gmail.com  
 
Details of Contact Person
Scientific Query
 
Name  Dr Divya Stuvert 
Designation  Associate Professor 
Affiliation  SDM Institute of Ayurveda Bangalore 
Address  Shri Dharmasthala Manjunatheshwara Institute Of Ayurveda And Hospital Bangalore Anchepalya Kumbalgodu Post 560074

Bangalore
KARNATAKA
560074
India 
Phone  9481028050  
Fax    
Email  stuvertdivya@gmail.com  
 
Details of Contact Person
Public Query
 
Name  Dr Divya Stuvert 
Designation  Associate Professor 
Affiliation  SDM Institute of Ayurveda Bangalore 
Address  Shri Dharmasthala Manjunatheshwara Institute Of Ayurveda And Hospital Bangalore Anchepalya Kumbalgodu Post 560074

Bangalore
KARNATAKA
560074
India 
Phone  9481028050  
Fax    
Email  stuvertdivya@gmail.com  
 
Source of Monetary or Material Support  
SDM Institute of Ayurveda And Hospital Bangalore Anchepalya Kumbalgodu 560074 
 
Primary Sponsor  
Name  SDM Institute Of Ayurveda And Hospital  
Address  Shri Dharmasthala Manjunatheshwara Institute Of Ayurveda And Hospital Bangalore Anchepalya Kumbalgodu 560074 Shalakya Tantra Department  
Type of Sponsor  Private medical college 
 
Details of Secondary Sponsor  
Name  Address 
NIL  NIL 
 
Countries of Recruitment     India  
Sites of Study  
No of Sites = 1  
Name of Principal Investigator  Name of Site  Site Address  Phone/Fax/Email 
Dr Divya T N   SDM Institute Of Ayurveda And Hospital  OPD No 5 6 10 11 Department Of Shalakya Tantra Shri Dharmasthala Manjunatheshwara Institute Of Ayurveda And Hospital Bangalore Anchepalya Kumbalgodu Post 560074
Bangalore
KARNATAKA 
9113014759

divyatn00437@gmail.com 
 
Details of Ethics Committee  
No of Ethics Committees= 1  
Name of Committee  Approval Status 
Institutional ethics committee  Approved 
 
Regulatory Clearance Status from DCGI  
Status 
Not Applicable 
 
Health Condition / Problems Studied  
Health Type  Condition 
Patients  (1) ICD-10 Condition:H522||Astigmatism. Ayurveda Condition: TIMIRAH,  
 
Intervention / Comparator Agent  
snoIntervention/ComparatorTypeDrug-TypeProcedure NameDetails
1Intervention ArmProcedure-netratarpaNam, नेत्रतर्पणम् Pradhan Karma(Procedure Reference: Astanga Hridaya, Procedure details: Pradhana karma A circular wall will be constructed around the eye with dough of Masha flour & was made leak proof Then lukewarm Gritha will be poured over closed eyes slowly, from the height of 4inches, till the eye lashes were completely immersed in it. The patient will be advised to open his eyes & blink gently , the temperature of the Gritha was maintained throughout the procedure. The procedure will be carried out for 800 mathra kalas 8-10 min )
(1) Medicine Name: Tiktaka Gritha, Reference: Astanga Hridaya, Route: Ocular, Dosage Form: Ghrita, Dose: 60(ml), Frequency: od, Duration: 9 Days
2Comparator ArmProcedure-netratarpaNam, नेत्रतर्पणम् (Procedure Reference: Astanga Hridaya, Procedure details: Pradhana karma A circular wall will be constructed around the eye with dough of Masha flour & was made leak proof Then lukewarm Gritha will be poured over closed eyes slowly, from the height of 4’’, till the eye lashes were completely immersed in it. The patient will be advised to open his eyes and blink gently , the temperature of the Gritha was maintained throughout the procedure. The procedure will be carried out for 800 mathra kalas 8-10 min )
(1) Medicine Name: Mahatriphala Gritha, Reference: Chakradatta, Route: Ocular, Dosage Form: Ghrita, Dose: 60(ml), Frequency: od, Duration: 9 Days
 
Inclusion Criteria  
Age From  10.00 Year(s)
Age To  30.00 Year(s)
Gender  Both 
Details  Patient Presenting With Clinical Symptoms Of Simple Myopic Astigmatism
Patient Between 10 to 30 Years Of Age Irrespective Of Gender Are Selected
Refractive Error Ranging From minus 0.25D to minus 3.0D cylindrical
Visual Acuity Distant 0.1 to 0.7 Log MAR 
 
ExclusionCriteria 
Details  Simple And Compound Hypermetropic Astigmatism Irregular Astigmatism Mixed Astigmatism
Congenital And Pathological Astigmatism.
Patient With Astigmatism Suffering From Other Systemic Disorders.
Patients With Other Ocular Surface Disorders Showing Astigmatic Signs.
Corneal dystrophy. 
 
Method of Generating Random Sequence   Computer generated randomization 
Method of Concealment   Alternation 
Blinding/Masking   Open Label 
Primary Outcome  
Outcome  TimePoints 
Changes In Vision From The Base Score Will Be Assessed By Visual Acuity Using log MAR Distant Vision Chart  2 Weeks 
 
Secondary Outcome  
Outcome  TimePoints 
Changes In Dioptric Power Of Principle Meridians Will Be Assessed From The Base Line Through Keratometry.
Changes In Regularity Of Lines From The Base Line Will Be Assessed Through Placido Disc.
Changes In The Clarity Of Lines Across Specific Meridians, Reduction In double Vision From The Base Line Will Be Assessed Through Astigmatic Fan Test.
Changes In The Cylindrical Power And Axis From The Base Line Will Be Assessed Through Auto Refractometry.
To Analyze The Decrease In Scores Of QIRC Questionnaire From The Base Score.
To Analyze The Decrease In Grading Scores Of Asthenopic Symptoms From The Base Score. 
2 Weeks 
 
Target Sample Size   Total Sample Size="40"
Sample Size from India="40" 
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" 
Phase of Trial   Phase 2/ Phase 3 
Date of First Enrollment (India)   10/02/2026 
Date of Study Completion (India) Applicable only for Completed/Terminated trials 
Date of First Enrollment (Global)  Date Missing 
Date of Study Completion (Global) Applicable only for Completed/Terminated trials 
Estimated Duration of Trial   Years="1"
Months="6"
Days="0" 
Recruitment Status of Trial (Global)   Not Applicable 
Recruitment Status of Trial (India)  Not Yet Recruiting 
Publication Details   N/A 
Individual Participant Data (IPD) Sharing Statement

Will individual participant data (IPD) be shared publicly (including data dictionaries)?  

Response - NO
Brief Summary  
Ayurveda emphasizes the supreme importance of vision, stating Sarvendriyanam nayanam pradhanam, highlighting the eye as the most vital sensory organ. Timira, described under Drishtigata Rogas, is a progressive disorder that can lead to visual impairment and blindness if untreated. In contemporary ophthalmology, Timira encompasses refractive errors, including astigmatism, which is characterized by irregular curvature of the cornea leading to blurred vision, eye strain, headache, and watering of eyes. Astigmatism accounts for a significant proportion of refractive errors worldwide, with rising prevalence attributed to increased screen time, sedentary lifestyle, and reduced outdoor activities.
Conventional management options such as spectacles, contact lenses, and refractive surgeries provide symptomatic correction but do not prevent progression and may have cosmetic, economic, or procedural limitations. Ayurveda offers holistic therapeutic approaches, among which Netra Tarpana ,a Bahya Snehana procedure is indicated in Timira, particularly in Vata-predominant Tridoshaja conditions. Ghrita, described as Chakshushya, Rasayana, and Ojovardhaka, nourishes ocular tissues and pacifies Vata and Pitta doshas.
The present study is an open-label, double-arm controlled clinical trial designed to evaluate and compare the efficacy of Tiktaka Ghrita Tarpana with eye exercises versus Mahatriphala Ghrita Tarpana with eye exercises in the management of astigmatism . Forty patients aged 10–30 years with simple myopic astigmatism will be randomly allocated into two groups. Both groups will receive Tarpana for 9 days followed by guided eye exercises for 20 days.
Assessment will be done using subjective symptoms, visual acuity , keratometry, auto-refractometry, astigmatic fan test, and QIRC questionnaire. The study aims to scientifically validate Ayurvedic interventions in improving visual acuity, reducing asthenopic symptoms, and enhancing quality of life in patients with astigmatism .
 
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