| CTRI Number |
CTRI/2026/01/102164 [Registered on: 27/01/2026] Trial Registered Prospectively |
| Last Modified On: |
23/01/2026 |
| Post Graduate Thesis |
Yes |
| Type of Trial |
Interventional |
|
Type of Study
|
Physiotherapy (Not Including YOGA) |
| Study Design |
Other |
|
Public Title of Study
|
Effect of gentle nerve exercises on knee pain and movement in people with knee arthritis. |
|
Scientific Title of Study
|
Effectiveness of neural mobilization on pain severity, range and physical performance in individual with knee osteoarthritis |
| Trial Acronym |
NIL |
|
Secondary IDs if Any
|
| Secondary ID |
Identifier |
| NIL |
NIL |
|
|
Details of Principal Investigator or overall Trial Coordinator (multi-center study)
|
| Name |
YUGANISHA M |
| Designation |
Post Graduate Student |
| Affiliation |
Sri Ramachandra Institute of Higher Education and Research |
| Address |
Room no 1.5, first floor, Sri Ramachandra Faculty of Physiotherapy, Sri Ramachandra Institute of Higher Education and Research Nagar, Pour, Chennai
Chennai TAMIL NADU 600116 India |
| Phone |
09150913320 |
| Fax |
|
| Email |
t0224002@sriher.edu.in |
|
Details of Contact Person Scientific Query
|
| Name |
Dr HEPZIBAH RUBELLA D |
| Designation |
ASSISTANT PROFESSOR |
| Affiliation |
Sri Ramachandra Institute of Higher Education and Research |
| Address |
Room no 1.4, first floor, Sri Ramachandra Faculty of Physiotherapy, Sri Ramachandra Institute of Higher Education and Research Nagar, Pour, Chennai
Chennai TAMIL NADU 600116 India |
| Phone |
9600009396 |
| Fax |
|
| Email |
hepzibahd@sriramachandra.edu.in |
|
Details of Contact Person Public Query
|
| Name |
Dr HEPZIBAH RUBELLA D |
| Designation |
ASSISTANT PROFESSOR |
| Affiliation |
Sri Ramachandra Institute of Higher Education and Research |
| Address |
Room no 1.4, first floor, Sri Ramachandra Faculty of Physiotherapy, Sri Ramachandra Institute of Higher Education and Research Nagar, Pour, Chennai
Chennai TAMIL NADU 600116 India |
| Phone |
9600009396 |
| Fax |
|
| Email |
hepzibahd@sriramachandra.edu.in |
|
|
Source of Monetary or Material Support
|
| Sri Ramachandra Hospital New Block Physiotherapy OPD, Ground Floor
No:1 Sri Ramachandra Nagar,Porur,Chennai,Tamil Nadu-600116,India |
|
|
Primary Sponsor
|
| Name |
YUGANISHA M |
| Address |
Room no 1.5, first floor, Sri Ramachandra Faculty of Physiotherapy, Sri Ramachandra Institute of Higher Education and Research Nagar, Pour, Chennai,
Tamil Nadu-600116,
India
|
| Type of Sponsor |
Research institution and hospital |
|
|
Details of Secondary Sponsor
|
|
|
Countries of Recruitment
|
India |
|
Sites of Study
|
| No of Sites = 1 |
| Name of Principal
Investigator |
Name of Site |
Site Address |
Phone/Fax/Email |
| Dr Hepzibah Rubella d |
Sri Ramachandra Gblock Physiotherapy OPD |
New G block Physiotherapy OPD, Ground floor, Sri Ramachandra Institute of higher education and research, Porur, Chennai, Tamil Nadu-600116 Chennai TAMIL NADU |
9600009396
hepzibahd@sriramachandra.edu.in |
|
|
Details of Ethics Committee
|
| No of Ethics Committees= 1 |
| Name of Committee |
Approval Status |
| Ethics Committee for Student Project |
Approved |
|
|
Regulatory Clearance Status from DCGI
|
|
|
Health Condition / Problems Studied
|
| Health Type |
Condition |
| Patients |
(1) ICD-10 Condition: M179||Osteoarthritis of knee, unspecified, |
|
|
Intervention / Comparator Agent
|
| Type |
Name |
Details |
| Comparator Agent |
Any Kind of Conventional management as per orthopaedic advice |
Any Kind of Conventional management as per orthopaedic advice for 6 days once in a day
Duration-30 minutes |
| Intervention |
Neural Mobilization |
The intervention group will receive therapist-administered passive neural mobilization techniques targeting the femoral nerve and sciatic nerve. Femoral nerve mobilization will be performed in the prone position using passive knee flexion, and sciatic nerve mobilization will be performed in the supine position using passive straight leg raise with knee extension and ankle dorsiflexion. Each technique will be applied within the pain-free range for 10–15 repetitions for 6 days once in a day. Duration-30 minutes |
|
|
Inclusion Criteria
|
| Age From |
40.00 Year(s) |
| Age To |
65.00 Year(s) |
| Gender |
Both |
| Details |
Individuals with Knee OA (grade I -II)
Age group between 40 and 65 years
knee pain with vas score 4/10
|
|
| ExclusionCriteria |
| Details |
Knee deformities (genu varum/valgum/flexed knee deformities)
Severe osteoporosis
Peripheral nerve entrapment
Ligament injury
Recent lower limb fracture |
|
|
Method of Generating Random Sequence
|
Adaptive randomization, such as minimization |
|
Method of Concealment
|
Not Applicable |
|
Blinding/Masking
|
Participant Blinded |
|
Primary Outcome
|
| Outcome |
TimePoints |
| Pain intensity (Visual Analog Scale), physical performance (e.g. 6minute walk test), and range of motion. |
Baseline, After 6 days of post treatment |
|
|
Secondary Outcome
|
| Outcome |
TimePoints |
| NIL |
NIL |
|
|
Target Sample Size
|
Total Sample Size="52" Sample Size from India="52"
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" |
|
Phase of Trial
|
N/A |
|
Date of First Enrollment (India)
|
05/02/2026 |
| Date of Study Completion (India) |
Applicable only for Completed/Terminated trials |
| Date of First Enrollment (Global) |
05/02/2026 |
| Date of Study Completion (Global) |
Applicable only for Completed/Terminated trials |
|
Estimated Duration of Trial
|
Years="0" Months="4" Days="0" |
|
Recruitment Status of Trial (Global)
|
Not Applicable |
| Recruitment Status of Trial (India) |
Not Yet Recruiting |
|
Publication Details
|
N/A |
|
Individual Participant Data (IPD) Sharing Statement
|
Will individual participant data (IPD) be shared publicly (including data dictionaries)?
Response - NO
|
|
Brief Summary
|
Knee osteoarthritis (Grade I–II) is a common degenerative musculoskeletal condition associated with pain, stiffness, and functional limitations. This experimental study aims to evaluate the effectiveness of passive neural mobilization on pain, physical performance, and range of motion in individuals with knee osteoarthritis presenting with non-radiating knee pain. Participants will be recruited from the physiotherapy outpatient department based on inclusion criteria. After obtaining informed consent, baseline demographic and clinical data, including age, body mass index (BMI), range of motion, and physical performance, will be recorded. Special tests such as the Prone Knee Bend Test and Straight Leg Raise (SLR) will be performed.
Participants will be allocated into an intervention group and a control group. The intervention group will receive therapist-administered passive neural mobilization techniques targeting the femoral nerve and sciatic nerve. Femoral nerve mobilization will be performed in the prone position using passive knee flexion, and sciatic nerve mobilization will be performed in the supine position using passive straight leg raise with knee extension and ankle dorsiflexion. Each technique will be applied within the pain-free range for 10–15 repetitions. The control group will receive conventional physiotherapy management as advised by the orthopedic physician.
The intervention will be carried out for six days. Outcome measures will include pain intensity assessed using the Visual Analog Scale (VAS), physical performance assessed by the 6-Minute Walk Test, and knee range of motion. Assessments will be conducted on Day 1 and Day 6 of the intervention period. |