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CTRI Number  CTRI/2026/01/102164 [Registered on: 27/01/2026] Trial Registered Prospectively
Last Modified On: 23/01/2026
Post Graduate Thesis  Yes 
Type of Trial  Interventional 
Type of Study   Physiotherapy (Not Including YOGA) 
Study Design  Other 
Public Title of Study   Effect of gentle nerve exercises on knee pain and movement in people with knee arthritis. 
Scientific Title of Study   Effectiveness of neural mobilization on pain severity, range and physical performance in individual with knee osteoarthritis  
Trial Acronym  NIL 
Secondary IDs if Any  
Secondary ID  Identifier 
NIL  NIL 
 
Details of Principal Investigator or overall Trial Coordinator (multi-center study)  
Name  YUGANISHA M 
Designation  Post Graduate Student  
Affiliation  Sri Ramachandra Institute of Higher Education and Research 
Address  Room no 1.5, first floor, Sri Ramachandra Faculty of Physiotherapy, Sri Ramachandra Institute of Higher Education and Research Nagar, Pour, Chennai

Chennai
TAMIL NADU
600116
India 
Phone  09150913320  
Fax    
Email  t0224002@sriher.edu.in  
 
Details of Contact Person
Scientific Query
 
Name  Dr HEPZIBAH RUBELLA D 
Designation  ASSISTANT PROFESSOR 
Affiliation  Sri Ramachandra Institute of Higher Education and Research 
Address  Room no 1.4, first floor, Sri Ramachandra Faculty of Physiotherapy, Sri Ramachandra Institute of Higher Education and Research Nagar, Pour, Chennai

Chennai
TAMIL NADU
600116
India 
Phone  9600009396  
Fax    
Email  hepzibahd@sriramachandra.edu.in  
 
Details of Contact Person
Public Query
 
Name  Dr HEPZIBAH RUBELLA D 
Designation  ASSISTANT PROFESSOR 
Affiliation  Sri Ramachandra Institute of Higher Education and Research 
Address  Room no 1.4, first floor, Sri Ramachandra Faculty of Physiotherapy, Sri Ramachandra Institute of Higher Education and Research Nagar, Pour, Chennai

Chennai
TAMIL NADU
600116
India 
Phone  9600009396  
Fax    
Email  hepzibahd@sriramachandra.edu.in  
 
Source of Monetary or Material Support  
Sri Ramachandra Hospital New Block Physiotherapy OPD, Ground Floor No:1 Sri Ramachandra Nagar,Porur,Chennai,Tamil Nadu-600116,India  
 
Primary Sponsor  
Name  YUGANISHA M 
Address  Room no 1.5, first floor, Sri Ramachandra Faculty of Physiotherapy, Sri Ramachandra Institute of Higher Education and Research Nagar, Pour, Chennai, Tamil Nadu-600116, India  
Type of Sponsor  Research institution and hospital 
 
Details of Secondary Sponsor  
Name  Address 
NIL  NIL 
 
Countries of Recruitment     India  
Sites of Study  
No of Sites = 1  
Name of Principal Investigator  Name of Site  Site Address  Phone/Fax/Email 
Dr Hepzibah Rubella d  Sri Ramachandra Gblock Physiotherapy OPD   New G block Physiotherapy OPD, Ground floor, Sri Ramachandra Institute of higher education and research, Porur, Chennai, Tamil Nadu-600116
Chennai
TAMIL NADU 
9600009396

hepzibahd@sriramachandra.edu.in 
 
Details of Ethics Committee  
No of Ethics Committees= 1  
Name of Committee  Approval Status 
Ethics Committee for Student Project   Approved 
 
Regulatory Clearance Status from DCGI  
Status 
Not Applicable 
 
Health Condition / Problems Studied  
Health Type  Condition 
Patients  (1) ICD-10 Condition: M179||Osteoarthritis of knee, unspecified,  
 
Intervention / Comparator Agent  
Type  Name  Details 
Comparator Agent  Any Kind of Conventional management as per orthopaedic advice   Any Kind of Conventional management as per orthopaedic advice for 6 days once in a day Duration-30 minutes 
Intervention  Neural Mobilization  The intervention group will receive therapist-administered passive neural mobilization techniques targeting the femoral nerve and sciatic nerve. Femoral nerve mobilization will be performed in the prone position using passive knee flexion, and sciatic nerve mobilization will be performed in the supine position using passive straight leg raise with knee extension and ankle dorsiflexion. Each technique will be applied within the pain-free range for 10–15 repetitions for 6 days once in a day. Duration-30 minutes  
 
Inclusion Criteria  
Age From  40.00 Year(s)
Age To  65.00 Year(s)
Gender  Both 
Details  Individuals with Knee OA (grade I -II)
Age group between 40 and 65 years
knee pain with vas score 4/10
 
 
ExclusionCriteria 
Details  Knee deformities (genu varum/valgum/flexed knee deformities)
Severe osteoporosis
Peripheral nerve entrapment
Ligament injury
Recent lower limb fracture 
 
Method of Generating Random Sequence   Adaptive randomization, such as minimization 
Method of Concealment   Not Applicable 
Blinding/Masking   Participant Blinded 
Primary Outcome  
Outcome  TimePoints 
Pain intensity (Visual Analog Scale), physical performance (e.g. 6minute walk test), and range of motion.  Baseline, After 6 days of post treatment  
 
Secondary Outcome  
Outcome  TimePoints 
NIL  NIL 
 
Target Sample Size   Total Sample Size="52"
Sample Size from India="52" 
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" 
Phase of Trial   N/A 
Date of First Enrollment (India)   05/02/2026 
Date of Study Completion (India) Applicable only for Completed/Terminated trials 
Date of First Enrollment (Global)  05/02/2026 
Date of Study Completion (Global) Applicable only for Completed/Terminated trials 
Estimated Duration of Trial   Years="0"
Months="4"
Days="0" 
Recruitment Status of Trial (Global)   Not Applicable 
Recruitment Status of Trial (India)  Not Yet Recruiting 
Publication Details   N/A 
Individual Participant Data (IPD) Sharing Statement

Will individual participant data (IPD) be shared publicly (including data dictionaries)?  

Response - NO
Brief Summary  
Knee osteoarthritis (Grade I–II) is a common degenerative musculoskeletal condition associated with pain, stiffness, and functional limitations. This experimental study aims to evaluate the effectiveness of passive neural mobilization on pain, physical performance, and range of motion in individuals with knee osteoarthritis presenting with non-radiating knee pain. Participants will be recruited from the physiotherapy outpatient department based on inclusion criteria. After obtaining informed consent, baseline demographic and clinical data, including age, body mass index (BMI), range of motion, and physical performance, will be recorded. Special tests such as the Prone Knee Bend Test and Straight Leg Raise (SLR) will be performed.

Participants will be allocated into an intervention group and a control group. The intervention group will receive therapist-administered passive neural mobilization techniques targeting the femoral nerve and sciatic nerve. Femoral nerve mobilization will be performed in the prone position using passive knee flexion, and sciatic nerve mobilization will be performed in the supine position using passive straight leg raise with knee extension and ankle dorsiflexion. Each technique will be applied within the pain-free range for 10–15 repetitions. The control group will receive conventional physiotherapy management as advised by the orthopedic physician.

The intervention will be carried out for six days. Outcome measures will include pain intensity assessed using the Visual Analog Scale (VAS), physical performance assessed by the 6-Minute Walk Test, and knee range of motion. Assessments will be conducted on Day 1 and Day 6 of the intervention period.
 
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