1. What data in particular will be shared?
   Response - Individual participant data that underlie the results reported in this article, after de-identification (text, tables, figures, and appendices).
   


2. What additional supporting information will be shared?
   Response -  Statistical Analysis Plan
   
   
3. Who will be able to view these files?
   Response - Researchers who provide a methodologically sound proposal.
   


4. For what types of analyses will this data be available?
   Response - To achieve aims in the approved proposal.
   


5. By what mechanism will data be made available?
   Response - Proposals should be directed to [ameylathi@gmail.com].
   


6. For how long will this data be available start date provided 30-12-2027 and end date provided 30-12-2032?
   Response - Beginning 3 months and ending 5 years following article publication.
   


7. Any URL or additional information regarding plan/policy for sharing IPD? 
   Additional Information - NIL

Sepsis is a major cause of morbidity and mortality among hospitalized patients, particularly in intensive care settings, where early diagnosis and risk stratification are critical for improving outcomes. Conventional diagnostic tools such as blood cultures and biomarkers like C-reactive protein and procalcitonin have limitations related to sensitivity, specificity, cost, and availability.

Monocyte Distribution Width (MDW) is a novel parameter derived from routine complete blood count that reflects monocyte morphological changes during systemic inflammation and infection. It is rapid, cost-effective, and does not require additional testing. Given that MDW is available as part of routine hematological analysis without additional cost or testing, it may serve as a practical alternative or adjunct biomarker in resource-limited settings.

This prospective cross-sectional observational study aims to evaluate the diagnostic accuracy of MDW in identifying sepsis and to assess its prognostic value in predicting disease severity and patient outcomes. The study will also examine the correlation of MDW with established inflammatory markers such as CRP, NLR, RDW, and procalcitonin.

MDW will be measured at admission and serially during hospitalization, and its performance will be analyzed in comparison to standard biomarkers. The findings of this study may support the use of MDW as an accessible and reliable biomarker for early diagnosis and prognostication of sepsis.