| CTRI Number |
CTRI/2026/02/102881 [Registered on: 03/02/2026] Trial Registered Prospectively |
| Last Modified On: |
03/02/2026 |
| Post Graduate Thesis |
Yes |
| Type of Trial |
Interventional |
|
Type of Study
|
Physiotherapy (Not Including YOGA) |
| Study Design |
Randomized, Parallel Group, Active Controlled Trial |
|
Public Title of Study
|
Effect of Whole Body Vibration With Surface Variability in Knee Osteoarthritis Patients |
|
Scientific Title of Study
|
Effect of Whole Body Vibration With Surface Variability on Physical and Functional Parameters in Patients With Knee Osteoarthritis: A Randomized Controlled Trial |
| Trial Acronym |
NIL |
|
Secondary IDs if Any
|
| Secondary ID |
Identifier |
| NIL |
NIL |
|
|
Details of Principal Investigator or overall Trial Coordinator (multi-center study)
|
| Name |
Dr Zubia Veqar |
| Designation |
Director and Professor |
| Affiliation |
Centre For Physiotherapy and Rehabilitation Sciences, Jamia Millia Islamia |
| Address |
Room No. 202, 2nd Floor, Centre For Physiotherapy and Rehabilitation Sciences, Jamia Millia Islamia, Maulana Md Ali Jauhar Marg, Okhla, New Delhi-110025, India
South
DELHI
110025
India
New Delhi
DELHI
110025
India |
| Phone |
9958993486 |
| Fax |
|
| Email |
veqar.zubia@gmail.com |
|
Details of Contact Person
Scientific Query
|
| Name |
Dr Zubia Veqar |
| Designation |
Director and Professor |
| Affiliation |
Centre For Physiotherapy and Rehabilitation Sciences, Jamia Millia Islamia |
| Address |
Room No. 202, 2nd Floor, Centre For Physiotherapy and Rehabilitation Sciences, Jamia Millia Islamia, Maulana Md Ali Jauhar Marg, Okhla, New Delhi-110025, India
South
DELHI
110025
India
New Delhi
DELHI
110025
India |
| Phone |
9958993486 |
| Fax |
|
| Email |
veqar.zubia@gmail.com |
|
Details of Contact Person
Public Query
|
| Name |
Tabassum Jamal |
| Designation |
Student |
| Affiliation |
Centre For Physiotherapy and Rehabilitation Sciences, Jamia Millia Islamia |
| Address |
Room No. 207, 2nd Floor, Centre For Physiotherapy and Rehabilitation Sciences, Jamia Millia Islamia, Maulana Md Ali Jauhar Marg, Okhla, New Delhi-110025, India
South
DELHI
110025
India
New Delhi
DELHI
110025
India |
| Phone |
7424952440 |
| Fax |
|
| Email |
45tabassumjamal@gmail.com |
|
|
Source of Monetary or Material Support
|
| Centre For Physiotherapyband Rehabilitation Sciences, Jamia Millia Islamia, New Delhi, India |
|
|
Primary Sponsor
|
| Name |
Centre For Physiotherapy and Rehabilitation Sciences,Jamia Millia Islamia |
| Address |
Centre For Physiotherapy and Rehabilitation Sciences, Jamia Millia Islamia, Maulana Md Ali Jauhar Marg, Okhla, New Delhi-110025, India |
| Type of Sponsor |
Other [[Central University] ] |
|
|
Details of Secondary Sponsor
|
|
|
Countries of Recruitment
|
India |
|
Sites of Study
|
| No of Sites = 1 |
| Name of Principal
Investigator |
Name of Site |
Site Address |
Phone/Fax/Email |
| Dr Zubia Veqar |
Jamia Millia Islamia |
Centre for Physiotherapy and Rehabilitation Sciences clinic (OPD) Room no. 8, ground floor, Jamia Millia Islamia
South
DELHI
South
DELHI |
9958993486
veqar.zubia@gmail.com |
|
|
Details of Ethics Committee
|
| No of Ethics Committees= 1 |
| Name of Committee |
Approval Status |
| Institutional Ethics committee, Jamia Millia Islamia |
Approved |
|
|
Regulatory Clearance Status from DCGI
|
|
|
Health Condition / Problems Studied
|
| Health Type |
Condition |
| Patients |
(1) ICD-10 Condition: M171||Unilateral primary osteoarthritisof knee, |
|
|
Intervention / Comparator Agent
|
| Type |
Name |
Details |
| Comparator Agent |
Control group |
Whole body vibration training on standard vibration platform and the surface is stable, along with conventional physiotherapy.
Patients in this group will stand on a whole-body vibration platform which will oscillate at a frequency of 25–30 Hz and amplitude of 5 mm. For each treatment session, subjects will stand on the vibration platform with their knees bent 20°-30° to the vertical with 30 seconds of rest between bouts. The training volume will be increased systematically over the 4-week training period by increasing the number of repetitions in one session. The training intensity will be increased by increasing the frequency (25 Hz–30 Hz) of the vibration or the time per repetition on the vibrating platform. The duration of the WBV training program will be a maximum of 10 1/2 minutes at the end of week 4. The ratio between rest and training time will be 1:1. |
| Intervention |
Experimental group |
Whole body vibration training on standard vibration platform and the surface is unstable by introducing wobble board on the vibration platform, along with conventional physiotherapy.
Patients in this group will stand on a whole-body vibration platform which will oscillate at a frequency of 25–30 Hz and amplitude of 5 mm. For each treatment session, subjects will stand on the vibration platform with their knees bent 20°-30° to the vertical with 30 seconds of rest between bouts. The training volume will be increased systematically over the 4-week training period by increasing the number of repetitions in one session. The training intensity will be increased by increasing the frequency (25 Hz–30 Hz) of the vibration or the time per repetition on the vibrating platform. The duration of the WBV training program will be a maximum of 10 1/2 minutes at the end of week 4. The ratio between rest and training time will be 1:1. |
|
|
Inclusion Criteria
|
| Age From |
18.00 Year(s) |
| Age To |
80.00 Year(s) |
| Gender |
Both |
| Details |
1. Both genders (male and female) of Age more than 18 years;
2. Patient had mild to moderate unilateral knee OA (Kellgren and Lawrence grade 2 or 3),
3. In case of bilateral involvement more severely involved joint will be considered and if both knee joints are equally affected then dominant limb will be considered,
4. Patients with pain above or equals to 3 and less than 7 on NPRS,
5. Able to maintain balance on unipedal stance test with eyes open for at least 10 s and with eyes closed for at least 5 s,
6. Patients having working knowledge of English.
|
|
| ExclusionCriteria |
| Details |
1. History of knee surgery or joint replacement e.g., total knee arthroplasty,
2. Any other musculoskeletal conditions;
3. With any neurological and cardiorespiratory disorder that might interfere with the treatment or testing program;
4. Vestibular or balance disorders like vertigo
5. Patients with cognitive impairments affecting ability to follow instructions;
6. Use of assistive devices for walking e.g., walker, crutches
7. Participation in structured lower limb strengthening or balance training in the past 3 months
8. Individuals who received any intra-articular injections to treat OA within 4 weeks before the study
9. Presence of implanted medical devices (e.g., cardiac pacemaker, IUDs, metal pins or plates, joint prosthesis incompatible with vibration therapy).
10. Any systemic or inflammatory arthritis conditions (e.g., rheumatoid arthritis, septic arthritis);
11. Uncontrolled metabolic disorders ( e.g., uncontrolled diabetes mellitus, uncontrolled hypertension).
|
|
|
Method of Generating Random Sequence
|
Computer generated randomization |
|
Method of Concealment
|
Sequentially numbered, sealed, opaque envelopes |
|
Blinding/Masking
|
Participant Blinded |
|
Primary Outcome
|
| Outcome |
TimePoints |
Pain
Range of motion
Muscle strength
Gait
Balance |
At baseline
At 4 weeks |
|
|
Secondary Outcome
|
| Outcome |
TimePoints |
Functional mobility
Health related quality of life
Disability |
At baseline
At 4 weeks |
|
|
Target Sample Size
|
Total Sample Size="40"
Sample Size from India="40"
Final Enrollment numbers achieved (Total)= "0"
Final Enrollment numbers achieved (India)="0" |
|
Phase of Trial
|
N/A |
|
Date of First Enrollment (India)
|
14/02/2026 |
| Date of Study Completion (India) |
Date Missing |
| Date of First Enrollment (Global) |
Date Missing |
| Date of Study Completion (Global) |
Date Missing |
|
Estimated Duration of Trial
|
Years="0"
Months="6"
Days="0" |
|
Recruitment Status of Trial (Global)
|
Not Applicable |
| Recruitment Status of Trial (India) |
Completed |
|
Publication Details
|
N/A |
|
Individual Participant Data (IPD) Sharing Statement
|
Will individual participant data (IPD) be shared publicly (including data dictionaries)?
Response - NO
|
|
Brief Summary
|
This study will be carried out at the Centre for Physiotherapy and Rehabilitation Sciences (CPRS), Jamia Millia Islamia, New Delhi. Patients with Knee Osteoarthritis will be recruited from the university campus and outpatient department based on predefined inclusion and exclusion criteria. All eligible participants will be informed in detail about the nature, purpose, and procedures of the study. The potential benefits and minimal risks involved will be clearly explained. Written informed consent will be obtained from all participants prior to participation (According to Helsinki declaration,1964). Following screening, demographic details including age, gender, height, weight, and body mass index (BMI), BP and heart rate will be recorded. After that subjects will undergo baseline evaluation of pain intensity will be assessed using NPRS scale, range of motion of Knee flexion and extension will be assessed using Electro goniometry, Quadriceps and hamstring muscle strength will be assessed using Lafayette Handheld Dynamometer, gait (Stride length, Step length, Stride time, Step time, Gait velocity, Cadence) will be assessed using GaitON, balance (COP sway, COP range, Reaction time, Proprioception) will be assessed using Pedalosensamove, functional mobility will be assessed using Time Up and Go test, health related quality of life will be assessed using Short F-36 Questionnaire, and disability will be assessed using WOMAC Questionnair. After completion of baseline assessments, participants will be randomly assigned to one of the two groups: Group A: control group – perform whole body vibration training on stable platform, Group B: experimental group - perform whole body vibration training on unstable platform, Both groups will be given conventional treatment and active exercises. Following the administration of 16 sessions of intervention over a period of 4 weeks (4 sessions per week, 40–45 minutes per session). Outcome measures will be reassessed at the end of 4 weeks using the same assessment procedures as at baseline. |