CTRI

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CTRI Number

CTRI/2026/01/100990 [Registered on: 13/01/2026] Trial Registered Prospectively

Last Modified On:

12/01/2026

Post Graduate Thesis

Yes

Type of Trial

Interventional

Type of Study

Physiotherapy (Not Including YOGA)
Nutraceutical

Study Design

Randomized, Crossover Trial

Public Title of Study

The impact of taurine intake and mouth rinsing on body functions and athlete performance.

Scientific Title of Study

Effect of taurine ingestion and mouth rinsing on physiological and performance variables in athletes.

Trial Acronym

NIL

Secondary IDs if Any

Secondary ID	Identifier
NIL	NIL

Details of Principal Investigator or overall Trial Coordinator (multi-center study)

Name	Dr Deepak Raghav
Designation	Professor
Affiliation	Santosh Medical College, Santosh Deemed to be University
Address	Department of Physiotherapy, Santosh Medical College, Santosh Deemed to be University, Sector 12, Pratap Vihar, Ghaziabad Ghaziabad UTTAR PRADESH 201009 India
Phone	9868315824
Fax
Email	deepak.raghav@santosh.ac.in

Details of Contact Person
Scientific Query

Name	Vikram Singh Yadav
Designation	PhD Scholar
Affiliation	Santosh Medical College, Santosh Deemed to be University
Address	Department of Physiotherapy, Santosh Medical College, Santosh Deemed to be University, Sector 12, Pratap Vihar, Ghaziabad Ghaziabad UTTAR PRADESH 201009 India
Phone	7015336462
Fax
Email	emailvsy5@gmail.com

Details of Contact Person
Public Query

Name	Vikram Singh Yadav
Designation	PhD Scholar
Affiliation	Santosh Medical College, Santosh Deemed to be University
Address	Department of Physiotherapy, Santosh Medical College, Santosh Deemed to be University, Sector 12, Pratap Vihar, Ghaziabad Ghaziabad UTTAR PRADESH 201009 India
Phone	7015336462
Fax
Email	emailvsy5@gmail.com

Source of Monetary or Material Support

Department of Physiotherapy, Santosh Medical College, Santosh Deemed to be University, Ghaziabad

Primary Sponsor

Name	Santosh Medical College
Address	Department of Physiotherapy, Santosh Medical College, Santosh Deemed to be University, Sector 12, Pratap Vihar, Ghaziabad-201009, India
Type of Sponsor	Private medical college

Details of Secondary Sponsor

Name	Address
Nil	Nil

Countries of Recruitment

India

Sites of Study

No of Sites = 1
Name of Principal Investigator	Name of Site	Site Address	Phone/Fax/Email
Dr Deepak Raghav	Santosh Medical College	Room No-01, Department of Physiotherapy, Santosh Medical College, Santosh Deemed to be University, Ghaziabad-201009, India Ghaziabad UTTAR PRADESH	9868315824 deepak.raghav@santosh.ac.in

Details of Ethics Committee

No of Ethics Committees= 1
Name of Committee	Approval Status
ETHICS COMMITTEE OF SANTOSH DEEMED TO BE UNIVERSITY	Approved

Regulatory Clearance Status from DCGI

Status

Not Applicable

Health Condition / Problems Studied

Health Type	Condition
Healthy Human Volunteers	Healthy Human Volunteers

Intervention / Comparator Agent

Type	Name	Details
Comparator Agent	Starch	During this session subjects will be provided with 250 ml starch solution in plain water for ingestion, which will serve as placebo. After 01 Hr of ingestion of starch solution various study physiological and performance variables will be measured using appropriate tools and tests. Measurements during this test session will act as a baseline data.
Intervention	Taurine	During this session prior to testing subjects will perform repeated taurine mouth rinsing with prepared 250 ml taurine solution. Taurine mouth rinsing will be for 10 sec with 25 ml solution each time, repeatedly for 10 times. Immediately after taurine mouth rinsing various study physiological and performance variables will be measured using appropriate tools and tests.
Intervention	Taurine	During this session subjects will ingest prepared 250 ml of taurine solution 01 Hr prior to the testing. After 01 Hr of taurine ingestion, various study physiological and performance variables will be measured using appropriate tools and tests.

Inclusion Criteria

Age From	20.00 Year(s)
Age To	30.00 Year(s)
Gender	Male
Details	Individuals who are willing to participate. Athletes with no history of allergy to taurine or protein supplements. Physically healthy male track & field athletes within the age group of 20 to 30 Yrs. Individuals who had not consumed creatine, taurine & protein supplements within the past 03 months.

ExclusionCriteria

Details

Athletes who are consuming NSAIDS or steroidal drugs.
Athletes who had consumed energy drinks in last 07 days.
Athletes who smokes, consumes alcohol and uses ergogenic aids.
Athletes with history of musculoskeletal injuries in last 06 months.
Athletes with known history of respiratory and cardiovascular disease.

Method of Generating Random Sequence

Computer generated randomization

Method of Concealment

Sequentially numbered, sealed, opaque envelopes

Blinding/Masking

Participant Blinded

Primary Outcome

Outcome	TimePoints
Time to Exhaustion Explosive power of lower limb Explosive power of upper limb Agility Balance Heart rate Heart rate variability Blood pressure Blood lactate levels Blood glucose levels Reaction Time	Immediately after taurine mouth rinsing and 1Hr after taurine and placebo ingestion.

Secondary Outcome

Outcome	TimePoints
Nil	Nil

Target Sample Size

Total Sample Size="53"
Sample Size from India="53"
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials"

Phase of Trial

N/A

Date of First Enrollment (India)

23/01/2026

Date of Study Completion (India)

Applicable only for Completed/Terminated trials

Date of First Enrollment (Global)

Date Missing

Date of Study Completion (Global)

Applicable only for Completed/Terminated trials

Estimated Duration of Trial

Years="1"
Months="6"
Days="0"

Recruitment Status of Trial (Global)

Not Applicable

Recruitment Status of Trial (India)

Not Yet Recruiting

Publication Details

N/A

Individual Participant Data (IPD) Sharing Statement

Will individual participant data (IPD) be shared publicly (including data dictionaries)?

Response - NO

Brief Summary

Primary purpose of this study is to determine if a single dose of taurine significantly alters the physiological and performance metrics in athletes when compared to placebo, comparing two delivery methods: oral ingestion and mouth rinsing. Further it is hypothesized that both taurine ingestion and mouth rinsing will elicit distinct, effect on physiological and performance related variables in athletes, with the delivery methods potentially influencing the magnitude of these effects.