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CTRI Number  CTRI/2026/02/103645 [Registered on: 11/02/2026] Trial Registered Prospectively
Last Modified On: 06/02/2026
Post Graduate Thesis  Yes 
Type of Trial  Interventional 
Type of Study   Surgical/Anesthesia 
Study Design  Randomized, Parallel Group, Active Controlled Trial 
Public Title of Study   A study comparing regional and general anesthesia to prevent sudden thigh jerks during bladder tumour surgery 
Scientific Title of Study   Comparison of bladder tumour resection under nerve stimulator guided obturator nerve block versus neuromuscular blockade 
Trial Acronym  NIL 
Secondary IDs if Any  
Secondary ID  Identifier 
NIL  NIL 
 
Details of Principal Investigator or overall Trial Coordinator (multi-center study)  
Name  Abdul Qadir Boringwala 
Designation  DrNB resident 
Affiliation  Dr Babasaheb Ambedkar Hospital and medical college 
Address  Room no 1123, Department of Urology, Hospital Wing, Dr Baba Saheb Ambedkar Hospital and Medical College, Rohini Sector 6, New Delhi 110085

North West
DELHI
110085
India 
Phone  9420607352  
Fax    
Email  Airechobabdulqadir@gmail.com  
 
Details of Contact Person
Scientific Query
 
Name  Dr Devesh Bhatia 
Designation  HOD Urology 
Affiliation  Dr Babasaheb Ambedkar Hospital and medical college 
Address  Ward 52, Department of Urology, Dr Baba Saheb Ambedkar Hospital and Medical College, Sector 6, Rohini, New Delhi 110085

North West
DELHI
110085
India 
Phone  9311967481  
Fax    
Email  dr.bhatia.devesh@gmail.com  
 
Details of Contact Person
Public Query
 
Name  Abdul Qadir Boringwala 
Designation  DrNB resident 
Affiliation  Dr Babasaheb Ambedkar Hospital and medical college 
Address  Room no 1123, Department of Urology, Hospital Wing, Dr Baba Saheb Ambedkar Hospital and Medical College, Rohini Sector 6, New Delhi 110085

North West
DELHI
110085
India 
Phone  9420607352  
Fax    
Email  Airechobabdulqadir@gmail.com  
 
Source of Monetary or Material Support  
Dr. Baba Saheb Ambedkar Hospital and Medical College, Sector 6, Rohini, New Delhi, India 110085 
 
Primary Sponsor  
Name  Dept of Urology Dr Baba Saheb Ambedkar Hospital And Medical College 
Address  Room no 1123, Department of Urology, Dr Baba Saheb Ambedkar Hospital and Medical College, Rohini Sector 6, New Delhi 110085 
Type of Sponsor  Government medical college 
 
Details of Secondary Sponsor  
Name  Address 
NIL  NIL 
 
Countries of Recruitment     India  
Sites of Study  
No of Sites = 1  
Name of Principal Investigator  Name of Site  Site Address  Phone/Fax/Email 
Dr Abdul Qadir Boringwala  Dr Babasaheb Ambedkar Hospital and Medical College  Room no 1123, Department of Urology, Hospital Wing, Dr Babasaheb Ambedkar Hospital and Medical College, Sector 6, Rohini, New Delhi 110085
North West
DELHI 
9420607352

Airecho6abdulqadir@gmail.com 
 
Details of Ethics Committee  
No of Ethics Committees= 1  
Name of Committee  Approval Status 
Institutional Ethics Committee of Dr Baba Saheb Ambedkar Hospital and Medical College  Approved 
 
Regulatory Clearance Status from DCGI  
Status 
Not Applicable 
 
Health Condition / Problems Studied  
Health Type  Condition 
Patients  (1) ICD-10 Condition: D303||Benign neoplasm of bladder, (2) ICD-10 Condition: D090||Carcinoma in situ of bladder, (3) ICD-10 Condition: C679||Malignant neoplasm of bladder, unspecified, (4) ICD-10 Condition: C672||Malignant neoplasm of lateral wallof bladder, (5) ICD-10 Condition: O||Medical and Surgical, (6) ICD-10 Condition: D494||Neoplasm of unspecified behavior of bladder,  
 
Intervention / Comparator Agent  
Type  Name  Details 
Comparator Agent  General Anesthesia with Neuro Muscular Blockade  In patients with lateral wall bladder tumours planned for TURBT the anesthesia would be General anesthesia with Neuro muscular blockade. Duration- from the start to the end of surgery, depend on tumour burden 
Intervention  Regional Anesthesia with nerve stimulator guided Obturator Nerve Block  In patients with lateral wall bladder tumours planned for TURBT the anesthesia would be regional with Obturator nerve block performed on the side of the lesion using nerve stimulator. Duration- depends on tumour burden and the expected surgery duration. 
 
Inclusion Criteria  
Age From  18.00 Year(s)
Age To  99.00 Year(s)
Gender  Both 
Details  Patients with urinary bladder masses located on the lateral and/or posterolateral bladder wall
(confirmed on preoperative CT scan) undergoing Monopolar TURBT fit for surgery 
 
ExclusionCriteria 
Details  Those unfit for either GA or regional anesthesia (RA)
Uncorrected coagulopathy
Allergy to local anaesthetic
Active infection at block site.
Pregnancy
Emergency procedures
Patient refusal  
 
Method of Generating Random Sequence   Permuted block randomization, variable 
Method of Concealment   Sequentially numbered, sealed, opaque envelopes 
Blinding/Masking   Not Applicable 
Primary Outcome  
Outcome  TimePoints 
1.Presence of obturator jerk (yes/no)
2.Count of Obturator Jerk events
3. management by the team (use of short bursts, change of cautery settings, switching to GA+NMB, deepening the NMB)
4. Completeness of resection: at the end of TURBT by the surgeon (complete / incomplete / uncertain)
5. Presence of detrusor muscle in specimen From histopathology report (Y/N).
6. Bladder perforation (Y/N) 
Intra Operatively- Bladder perforation, Presence of obturator jerk, Count of obturator jerk, management by the team for jerks
Completeness of resection by surgeon- immediately after the surgery
Presence of muscle in specimen- 15 days post operatively. 
 
Secondary Outcome  
Outcome  TimePoints 
1. Anaesthesia Time: Time required to give Regional anaesthesia + ONB vs time required for GA + NMB till handover to operating surgeon, time for reversal of GA+NMB
2. Operative resection time: scope insertion to scope removal (minutes).
3. Change in haematocrit pre- & post-surgery
4. Complications of anesthesia (local site hematoma, inadvertent nerve injury, Intra vascular injury, postoperative local site pain, airway complications, pulmonary complications, post operative nausea vomiting &
anaphylactic reactions, aspiration)
5. length of hospital stays (days)
6. Need for Re-interventions, if any, within 48hrs 
1- From anesthesia start to handover to surgeon; reversal time at end of surgery.
2- During surgery
3- pre operative baseline & 6 hours post surgery
4- 24 hours
5- at time of discharge
6- 48 hours 
 
Target Sample Size   Total Sample Size="90"
Sample Size from India="90" 
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" 
Phase of Trial   N/A 
Date of First Enrollment (India)   30/03/2026 
Date of Study Completion (India) Applicable only for Completed/Terminated trials 
Date of First Enrollment (Global)  Date Missing 
Date of Study Completion (Global) Applicable only for Completed/Terminated trials 
Estimated Duration of Trial   Years="2"
Months="0"
Days="0" 
Recruitment Status of Trial (Global)   Not Applicable 
Recruitment Status of Trial (India)  Not Yet Recruiting 
Publication Details   N/A 
Individual Participant Data (IPD) Sharing Statement

Will individual participant data (IPD) be shared publicly (including data dictionaries)?  

Response - NO
Brief Summary  

Transurethral resection of bladder tumor TURBT is a common procedure for diagnosis and treatment of bladder cancer. Tumors located on the lateral and posterolateral bladder wall often cause intraoperative obturator nerve stimulation leading to sudden thigh adduction known as obturator jerk. This can result in bladder perforation, incomplete resection, and increased morbidity. Two main strategies are used to prevent this complication. One is obturator nerve block ONB performed with regional anesthesia and the other is general anesthesia with neuromuscular blockade GA NMB. While GA NMB reliably abolishes obturator reflex, it carries risks in elderly patients with comorbidities. ONB is safer in such patients but technically demanding. Evidence comparing surgeon performed nerve stimulator guided ONB with GA NMB in the Indian setting is limited.

This prospective randomized controlled trial will compare the effectiveness of ONB with regional anesthesia versus GA with NMB in patients undergoing TURBT for lateral and posterolateral bladder wall tumors. The primary outcome is incidence of obturator jerk. Secondary outcomes include completeness of resection, presence of detrusor muscle in specimen, bladder perforation, operative time, anesthesia time, complications, hospital stay, and need for reintervention. Ninety patients will be randomized equally into two groups. Results will help determine whether surgeon performed ONB is non inferior to GA NMB in preventing obturator jerk and improving surgical outcomes in routine practice

 
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