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CTRI Number  CTRI/2026/01/101368 [Registered on: 16/01/2026] Trial Registered Prospectively
Last Modified On: 16/01/2026
Post Graduate Thesis  No 
Type of Trial  Observational 
Type of Study   Prospective Observational Study 
Study Design  Single Arm Study 
Public Title of Study   Evaluating The Role Of Internal Jugular Vein Collapsibility Index (IJVCI) In Supine And In Head Up Position For Predicting Post Spinal Hypotension In Elderly Patients Posted For Lower Limb Surgeries 
Scientific Title of Study   To Evaluate The Role Of Internal Jugular Vein Collapsibility Index (IJVCI) In Supine And In Head Up Position For Predicting Post Spinal Hypotension In Geriatric Patients Posted For Lower Limb Surgeries 
Trial Acronym  NIL 
Secondary IDs if Any  
Secondary ID  Identifier 
NIL  NIL 
 
Details of Principal Investigator or overall Trial Coordinator (multi-center study)  
Name  Dr Nandini C V 
Designation  Associate Professor 
Affiliation  Dr B R Ambedkar Medical College and Hospital 
Address  Department of Anaesthesiology, Dr B R Ambedkar Medical College and Hospital, Kadugondanahalli, Bangalore

Bangalore
KARNATAKA
560045
India 
Phone  9535024072  
Fax    
Email  nandinivraj@yahoo.co.in  
 
Details of Contact Person
Scientific Query
 
Name  Dr Nandini C V 
Designation  Associate Professor 
Affiliation  Dr B R Ambedkar Medical College and Hospital 
Address  Department of Anaesthesiology, Dr B R Ambedkar Medical College and Hospital, Kadugondanahalli, Bangalore

Bangalore
KARNATAKA
560045
India 
Phone  9535024072  
Fax    
Email  nandinivraj@yahoo.co.in  
 
Details of Contact Person
Public Query
 
Name  Dr Nandini C V 
Designation  Associate Professor 
Affiliation  Dr B R Ambedkar Medical College and Hospital 
Address  Department of Anaesthesiology, Dr B R Ambedkar Medical College and Hospital, Kadugondanahalli, Bangalore

Bangalore
KARNATAKA
560045
India 
Phone  9535024072  
Fax    
Email  nandinivraj@yahoo.co.in  
 
Source of Monetary or Material Support  
Dr B R Ambedkar Medical College and Hospital, Kadugondanahalli, Bangalore 560045, Karnataka , India  
 
Primary Sponsor  
Name  Dr Nandini C V 
Address  Department of Anaesthesiology, Dr B R Ambedkar Medical College and Hospital, Kadugondanahalli, Bangalore 560045, Karnataka, India  
Type of Sponsor  Other [self ] 
 
Details of Secondary Sponsor  
Name  Address 
NIL  NIL 
 
Countries of Recruitment     India  
Sites of Study  
No of Sites = 1  
Name of Principal Investigator  Name of Site  Site Address  Phone/Fax/Email 
Dr Nandini C V   Dr B R Ambedkar Hospital  Department Of Anaesthesiology, Major OT complex, 3rd floor
Bangalore
KARNATAKA 
9535024072

nandinivraj@yahoo.co.in 
 
Details of Ethics Committee  
No of Ethics Committees= 1  
Name of Committee  Approval Status 
Institution Ethics Committee, Dr B R Ambedkar Medical College  Approved 
 
Regulatory Clearance Status from DCGI  
Status 
Not Applicable 
 
Health Condition / Problems Studied  
Health Type  Condition 
Patients  (1) ICD-10 Condition: O||Medical and Surgical,  
 
Intervention / Comparator Agent  
Type  Name  Details 
Intervention  Nil  Nil 
 
Inclusion Criteria  
Age From  60.00 Year(s)
Age To  99.00 Year(s)
Gender  Both 
Details  Patients posted for elective lower limb surgery belonging to ASA I, II, III 
 
ExclusionCriteria 
Details  Patients with known coagulation or bleeding disorder
Patient with raised intracranial pressure
Patients with local site infection
Patients with spine deformity  
 
Method of Generating Random Sequence   Not Applicable 
Method of Concealment   Not Applicable 
Blinding/Masking   Investigator Blinded 
Primary Outcome  
Outcome  TimePoints 
To determine whether the internal jugular vein collapsibility index (IJVCI) measured in supine and thirty degree head up preoperatively using ultrasonography can predict the development of post spinal hypotension in geriatric patients undergoing lower limb surgeries under spinal anaesthesia  Baseline, 15mins Before Subarachnoid Block  
 
Secondary Outcome  
Outcome  TimePoints 
To compare IJVCI values between geriatric patients who develop post spinal hypotension & those who do not  Baseline, Before Subarachnoid block, After subarachnoid block, 5min after, 10mins, 15mins, 20mins, 25minutes, 30minutes  
To identify optimal IJVCI cutoff value that best predicts post spinal hypotension in this population  Baseline, Before Subarachnoid block, After subarachnoid block, 5min after, 10mins, 15mins, 20mins, 25minutes, 30minutes  
To examine the relationship between baseline hemodynamic parameters (SBP, DBP, MAP, HR) & development of post spinal hypotension   Baseline, Before Subarachnoid block, After subarachnoid block, 5min after, 10mins, 15mins, 20mins, 25minutes, 30minutes  
 
Target Sample Size   Total Sample Size="54"
Sample Size from India="54" 
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" 
Phase of Trial   N/A 
Date of First Enrollment (India)   30/01/2026 
Date of Study Completion (India) Applicable only for Completed/Terminated trials 
Date of First Enrollment (Global)  Date Missing 
Date of Study Completion (Global) Applicable only for Completed/Terminated trials 
Estimated Duration of Trial   Years="1"
Months="6"
Days="0" 
Recruitment Status of Trial (Global)   Not Applicable 
Recruitment Status of Trial (India)  Not Yet Recruiting 
Publication Details   N/A 
Individual Participant Data (IPD) Sharing Statement

Will individual participant data (IPD) be shared publicly (including data dictionaries)?  

Response - NO
Brief Summary  
Spinal anesthesia is widely used for a variety of surgical procedures because of its simplicity, rapid onset, and favorable safety profile. Advantages also include nil airway manipulation, avoidance of polypharmacy, minimizing blood loss and minimal interference with cognition in the perioperative period. 

Despite these advantages, post-spinal hypotension remains one of its most frequent and clinically significant complications. This drop in blood pressure occurs as a result of sympathetic blockade, leading to vasodilation and a relative reduction in circulating blood volume. In vulnerable groups—such as elderly patients, individuals with chronic illnesses, or those with limited physiological reserve—this hemodynamic instability can result in organ hypoperfusion, postoperative morbidity, prolonged hospitalization, and increased mortality. 

Traditional methods for assessing intravascular volume, including invasive monitoring or ultrasound assessment of the inferior vena cava, may be difficult to apply in all surgical settings due to limitations such as technical difficulty, patient body habitus, and the need for specialized equipment. 

The internal jugular vein (IJV), located superficially in the neck, easily visualised offers a more accessible window for ultrasonographic evaluation. Its collapsibility during respiration has been shown to correlate with intravascular volume status. Hence assessing the IJV collapsibility index may serve as a practical and rapid method to estimate a patient’s volume status before spinal anesthesia. 

Hence the aim of this study is to determine whether the internal jugular vein collapsibility index (IJVCI), measured through ultrasonography in supine and 30 degree head-up position, can reliably predict the occurrence of post-spinal hypotension in geriatric patients undergoing surgery under spinal anesthesia. By evaluating the relationship between pre-anesthetic IJV measurements and subsequent blood pressure changes, the study seeks to assess whether this noninvasive method can serve as an effective tool for identifying patients at increased risk of hemodynamic instability.
 
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