| CTRI Number |
CTRI/2026/01/101343 [Registered on: 16/01/2026] Trial Registered Prospectively |
| Last Modified On: |
16/01/2026 |
| Post Graduate Thesis |
Yes |
| Type of Trial |
Interventional |
|
Type of Study
|
Drug
Ayurveda |
| Study Design |
Randomized, Parallel Group Trial |
|
Public Title of Study
|
To see the effect of Triphala churna avachurnan in the management of Agantuj vrana ( excised wound ) |
|
Scientific Title of Study
|
Randomized controlled clinical study to find the efficacy of Triphala churna avachurnan in management of chinna vrana w.s. r excised wound |
| Trial Acronym |
NIL |
|
Secondary IDs if Any
|
| Secondary ID |
Identifier |
| NIL |
NIL |
|
|
Details of Principal Investigator or overall Trial Coordinator (multi-center study)
|
| Name |
Dr Ganesh Namdev Metkari |
| Designation |
MS Shalyatantra scholar |
| Affiliation |
DR VJD Gramin Ayurved Mahavidyalaya Near Renuka mata mandir, Patur |
| Address |
Department of Shalya Tantra,
Dr. VJD Gramin Ayurved Mahavidyalaya,
Opd No. 18
Patur, Dist. Akola,
Maharashtra, India – 444501
Department of Shalya Tantra,
Dr. VJD Gramin Ayurved Mahavidyalaya,
Opd No. 18
Patur, Dist. Akola,
Maharashtra, India – 444501
Akola
MAHARASHTRA
444501
India |
| Phone |
9359731528 |
| Fax |
|
| Email |
ganeshmetkari123@gmail.com |
|
Details of Contact Person
Scientific Query
|
| Name |
Dr Gayatri Dipak Mawale |
| Designation |
DR VJD Gramin Ayurved Mahavidyalaya Near Renuka mata mandir, Patur |
| Affiliation |
DR VJD Gramin Ayurved Mahavidyalaya Near Renuka mata mandir, Patur |
| Address |
Department of Shalya Tantra,
Dr. VJD Gramin Ayurved Mahavidyalaya,
Opd No. 18
Patur, Dist. Akola,
Maharashtra, India – 444501
Department of Shalya Tantra,
Dr. VJD Gramin Ayurved Mahavidyalaya,
Opd No. 18
Patur, Dist. Akola,
Maharashtra, India – 444501
Akola
MAHARASHTRA
444501
India |
| Phone |
9850500860 |
| Fax |
|
| Email |
gayatriakola@gmail.com |
|
Details of Contact Person
Public Query
|
| Name |
Dr Gayatri Dipak Mawale |
| Designation |
DR VJD Gramin Ayurved Mahavidyalaya Near Renuka mata mandir, Patur |
| Affiliation |
DR VJD Gramin Ayurved Mahavidyalaya Near Renuka mata mandir, Patur |
| Address |
Department of Shalya Tantra,
Dr. VJD Gramin Ayurved Mahavidyalaya,
Opd No. 18
Patur, Dist. Akola,
Maharashtra, India – 444501
Department of Shalya Tantra,
Dr. VJD Gramin Ayurved Mahavidyalaya,
Opd No. 18
Patur, Dist. Akola,
Maharashtra, India – 444501
Akola
MAHARASHTRA
444501
India |
| Phone |
9850500860 |
| Fax |
|
| Email |
gayatriakola@gmail.com |
|
|
Source of Monetary or Material Support
|
| Dr.VJD Gramin Ayurved Mahavidyalaya,near Renuka mata mandir,Patur,Tal-Patur,Dist-Akola Pin-444501 MAHARASHTRA INDIA
|
|
|
Primary Sponsor
|
| Name |
Dr.VJD Gramin Ayurved Mahavidyalaya |
| Address |
Dr.VJD Gramin Ayurved Mahavidyalaya,near Renuka mata mandir,Patur,Tal-Patur,Dist-Akola,Maharashtra,India Pin-444501 |
| Type of Sponsor |
Research institution and hospital |
|
|
Details of Secondary Sponsor
|
|
|
Countries of Recruitment
|
India |
|
Sites of Study
|
| No of Sites = 1 |
| Name of Principal
Investigator |
Name of Site |
Site Address |
Phone/Fax/Email |
| Dr Ganesh Namdev Metkari |
Dr VJD Gramin Ayurved Mahavidyalaya |
Opd no 18 Dr.VJD Gramin Ayurved Mahavidyalaya,near Renuka mata mandir,Patur,Tal-Patur,Dist-Akola,Maharashtra,India Pin-444501
Akola
MAHARASHTRA
Akola
MAHARASHTRA |
9359731528
ganeshmetkari123@gmail.com |
|
|
Details of Ethics Committee
|
| No of Ethics Committees= 1 |
| Name of Committee |
Approval Status |
| Institutional Ethics Committee Dr VJD Gramin Ayurved Mahavidyalaya Patur Akola |
Approved |
|
|
Regulatory Clearance Status from DCGI
|
|
|
Health Condition / Problems Studied
|
| Health Type |
Condition |
| Patients |
(1) ICD-10 Condition:T148||Other injury of unspecified body region. Ayurveda Condition: AGANTUJAVRANAH, |
|
|
Intervention / Comparator Agent
|
| sno | Intervention/Comparator | Type | Drug-Type | Procedure Name | Details | | 1 | Intervention Arm | Procedure | - | Avachurnan | (Procedure Reference: Sharandhar sanhita , Procedure details: 1) The affected area is cleaned and dried properly.
2) Finely sieved Triphala churna is taken.
3) The churna is gently sprinkled (dusted) over the lesion/wound.
4) Excess churna is removed; area may be covered lightly if required.
5) Procedure is once in a day..)
(1) Medicine Name: Triphala churna , Reference: Sushrut sanhita , Route: Topical, Dosage Form: Churna/ Powder, Dose: 200(mg), Frequency: od, Duration: 10 Days | | 2 | Comparator Arm (Non Ayurveda) | | - | Betadine Powder | “Betadine Powder applied topically as per wound condition. Dose is patient-specific and applied once daily until wound heals. Route: Topical, Dosage form: Powder. Reference: Standard pharmacopoeia / Manufacturer guidelines.” |
|
|
|
Inclusion Criteria
|
| Age From |
20.00 Year(s) |
| Age To |
60.00 Year(s) |
| Gender |
Both |
| Details |
1. Traumatic wound. ( Agantuj Vranna-Chhinna vranna)
2. Wound size up to length 5cm and depth less than 1.5cm.
3. Patients will be selected irrespective of their gender, caste and
socioeconomic status.
4. Patient age 20 to 60 yrs will be included.
5. Patients ready to give written consent will be selected.
6. Wound depth upto Masadhatu(only Twacha). |
|
| ExclusionCriteria |
| Details |
1. Known case of T.B
2. Burn wounds.
3. Leprosy wounds.
4. Wound having excessive loss of tissue.
5. Patient having malignant ulcers.
6. Osteomyelitis.
7. Size of wound more than 5cm.
8. Patient suffering from HIV, HbsAg, DM
9. Bleeding disorder.
10. Patient on Blood Thinner like Anti platelet and Thrombolytic Drug
11. Gangrenous.
12. Less than 20 yrs and more than 60 yrs of age.
13. Wound depth beyond the 1.5cm.
14. Medicolegal cases. |
|
|
Method of Generating Random Sequence
|
Coin toss, Lottery, toss of dice, shuffling cards etc |
|
Method of Concealment
|
An Open list of random numbers |
|
Blinding/Masking
|
Open Label |
|
Primary Outcome
|
| Outcome |
TimePoints |
Discontinuity of skin
Pain
Rakatstrav
Will be decreased |
1th,3rd,5th,7th,10th of the starting the treatment |
|
|
Secondary Outcome
|
| Outcome |
TimePoints |
| Decreased symptoms completely |
18 months |
|
|
Target Sample Size
|
Total Sample Size="70"
Sample Size from India="70"
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" |
|
Phase of Trial
|
N/A |
|
Date of First Enrollment (India)
|
31/01/2026 |
| Date of Study Completion (India) |
Applicable only for Completed/Terminated trials |
| Date of First Enrollment (Global) |
Date Missing |
| Date of Study Completion (Global) |
Applicable only for Completed/Terminated trials |
|
Estimated Duration of Trial
|
Years="1"
Months="6"
Days="1" |
|
Recruitment Status of Trial (Global)
|
Not Applicable |
| Recruitment Status of Trial (India) |
Not Yet Recruiting |
|
Publication Details
|
N/A |
|
Individual Participant Data (IPD) Sharing Statement
|
Will individual participant data (IPD) be shared publicly (including data dictionaries)?
Response - NO
|
|
Brief Summary
|
The current Review focus on Triphala churna and it’s potential to antimicrobial properties to minimize microbial burden in wound. Tropical application of Triphala churna helps in healing of wound. In general E.coli S.aureus, P.aursegunosa are common isolated Micro -organism in infected wound most of drugs are highly susceptible against above mentioned bacteria. Hence this review helps to understand the antimicrobial and healing properties of drugs that should be taken as antiseptic solution for use in ayurveda in the management of Agantuj vrana. This drug also has the vranaropak and vranashodhak properties. In modern era Betadine Powder prepared by Framycetin are used. It has some adverse effect like allergy, absorption of drug in less quantity, if large areas of the body are being treated then possibility of toxicity may occur. To minimize this adverse effect, this is a humble effort to prepare Triphala churna which might be useful in upcoming era and may be free from all these side effect and having good efficacy. Vrana literally means discontinuation of tissue or a condition which even after complete healing leaves a scar over the area which stays as long as the person is alive. Classification of Vrana: Aacharya Sushrut classified classes Vranas into according to their origin and etiology A) Nijvrana B) Aagantuj vrana Vrana and its management has been dotted since period of Veda to Current era. It has been a major problem Since early stage of medical science non-healing wound present serious problem for patient family, and clinician. Most of wound associated with a small number of under lying disorders such as DM, Leprosy and peripheral disease. Wound are Common place from childhood to old age and some time it required surgical intervention. |