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CTRI Number  CTRI/2026/03/105949 [Registered on: 11/03/2026] Trial Registered Prospectively
Last Modified On: 11/03/2026
Post Graduate Thesis  No 
Type of Trial  Interventional 
Type of Study   Dentistry 
Study Design  Randomized, Parallel Group Trial 
Public Title of Study   Role of diode laser and light therapy in improving the treatment of gum and tooth diseases 
Scientific Title of Study   Efficacy of diode laser (980nm) and photobiomodulation (980nm) in nonsurgical periodontal therapy 
Trial Acronym  NIL 
Secondary IDs if Any  
Secondary ID  Identifier 
NIL  NIL 
 
Details of Principal Investigator or overall Trial Coordinator (multi-center study)  
Name  Dr Munnam Vaishnavi 
Designation  post graduate student 
Affiliation  Vishnu Dental College 
Address  Block2, Room no 7, Department of Periodontics, Vishnupur, Bhimavaram

West Godavari
ANDHRA PRADESH
534202
India 
Phone  08978671135  
Fax  08816250894  
Email  munnamvaishnavi@gmail.com  
 
Details of Contact Person
Scientific Query
 
Name  Dr K Anil kumar 
Designation  Associate Professor  
Affiliation  Vishnu Dental College 
Address  Block2, Room no 7, Department of Periodontics, Vishnupur, Bhimavaram

West Godavari
ANDHRA PRADESH
534202
India 
Phone  9677209549  
Fax  08816250894  
Email  anilkumar.perio@vdc.edu.in  
 
Details of Contact Person
Public Query
 
Name  Dr K Anil kumar 
Designation  Associate Professor  
Affiliation  Vishnu Dental College 
Address  Block2, Room no 7, Department of Periodontics, Vishnupur, Bhimavaram

West Godavari
ANDHRA PRADESH
534202
India 
Phone  9677209549  
Fax  08816250894  
Email  anilkumar.perio@vdc.edu.in  
 
Source of Monetary or Material Support  
Vishnu Dental College, Vishnupur, Bhimavaram-534202, West Godavari, Andhra Pradesh, India 
 
Primary Sponsor  
Name  Dr Munnam Vaishnavi 
Address  Block2,Room no 7,Department of Periodontics,Vishnupur,Bhimavaram,West Godavari 
Type of Sponsor  Other [Self] 
 
Details of Secondary Sponsor  
Name  Address 
NIL  NIL 
 
Countries of Recruitment     India  
Sites of Study  
No of Sites = 1  
Name of Principal Investigator  Name of Site  Site Address  Phone/Fax/Email 
Dr Munnam Vaishnavi  Vishnu Dental College  Block2, Room no 7, Ground Floor, Department of Periodontics, Vishnupur, Bhimavaram-534202
West Godavari
ANDHRA PRADESH 
08978671135
08816250894
munnamvaishnavi@gmail.com 
 
Details of Ethics Committee  
No of Ethics Committees= 1  
Name of Committee  Approval Status 
Institutional Ethics Commitee, Vishnu Dental College  Approved 
 
Regulatory Clearance Status from DCGI  
Status 
Not Applicable 
 
Health Condition / Problems Studied  
Health Type  Condition 
Patients  (1) ICD-10 Condition: K053||Chronic periodontitis,  
 
Intervention / Comparator Agent  
Type  Name  Details 
Intervention  Laser irradiation and Photobiomodulation  Pocket will be irradiated with 980nm in a continuous mode(CW) of coronal and apical movement inside the periodontal pockets for 15 seconds with a power of 1W and photobiomodulation done with 980nm of wavelength,continuous wave mode,0.1 watt power,beam spot size 0.28cm2, duration of 30seconds at baseline, 1st,2nd, and 3rd weeks exposure from buccal surface in chronic periodontitis patients with probing pocket depth of 4-6 mm  
Intervention  Photobiomodulation  Laser beam of 980nm wavelength, will be focused in continuous wave mode with 0.1 watt power, beam spot size 0.28cm2 duration of 30seconds at baseline, 1st,2nd, and 3rd weeks exposure from buccal surface in chronic periodontitis patients with probing pocket depth of 4-6 mm 
Comparator Agent  scaling and root planing  scaling and root planing will be done in chronic periodontitis patients with probing pocket depth of 4-6mm only once during the first appointment 
 
Inclusion Criteria  
Age From  35.00 Year(s)
Age To  55.00 Year(s)
Gender  Both 
Details  1.Generalized Periodontitis Stage II Grade B
2.Minimum pocket depth of (4-6 mm) will be included
 
 
ExclusionCriteria 
Details  1.Patients with uncontrolled systemic diseases
2.Pregnancy or lactating women
3.Patients under anticoagulant therapy
4.Chronic smoker.
5.Patients with infectious diseases ( HIV, Hepatitis)
6.Patients under antibiotic therapy
 
 
Method of Generating Random Sequence   Computer generated randomization 
Method of Concealment   Case Record Numbers 
Blinding/Masking   Outcome Assessor Blinded 
Primary Outcome  
Outcome  TimePoints 
1.Inflammatory marker 1 beta
2.Probing pocket depth
3.Clinical attachment level
 
Baseline, 3 months 
 
Secondary Outcome  
Outcome  TimePoints 
1.Plaque index
2.Bleeding on probing 
Assesed at baseline,3 months 
 
Target Sample Size   Total Sample Size="45"
Sample Size from India="45" 
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" 
Phase of Trial   N/A 
Date of First Enrollment (India)   23/03/2026 
Date of Study Completion (India) Applicable only for Completed/Terminated trials 
Date of First Enrollment (Global)  Date Missing 
Date of Study Completion (Global) Applicable only for Completed/Terminated trials 
Estimated Duration of Trial   Years="0"
Months="6"
Days="0" 
Recruitment Status of Trial (Global)   Not Applicable 
Recruitment Status of Trial (India)  Not Yet Recruiting 
Publication Details   N/A 
Individual Participant Data (IPD) Sharing Statement

Will individual participant data (IPD) be shared publicly (including data dictionaries)?  

Response - NO
Brief Summary  
Patients reporting to the Department of Periodontics and Implantology Vishnu Dental College who are diagnosed with periodontal pocket depth of 4 to 6 mm will be recruited. Patients fulfilling the inclusion criteria will be selected. Informed consent will be taken. Patients will be divided into three groups. Clinical parameters such as plaque index, probing pocket depth, clinical attachment level and bleeding on probing will be assessed and gingival crevicular fluid collection will be done at baseline and at three months. Local anaesthesia will be administered at the site using two percent lignocaine. Scaling and root planing will be done for all three groups. In Test Group I photobiomodulation will be done from the buccal surface using a 980 nm diode laser for thirty seconds at baseline first second and third weeks. In Test Group II the pocket will first be irradiated with 980 nm diode laser in continuous mode with coronal and apical movement inside the periodontal pocket for fifteen seconds with a power of one watt followed by photobiomodulation from the buccal surface using a 980 nm diode laser for thirty seconds at baseline first second and third weeks. After the treatment the patient will be asked to return to the study center at three months for review of clinical parameters and gingival crevicular fluid collection for IL 1 beta.
 
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