| CTRI Number |
CTRI/2026/04/108964 [Registered on: 21/04/2026] Trial Registered Prospectively |
| Last Modified On: |
18/04/2026 |
| Post Graduate Thesis |
Yes |
| Type of Trial |
Interventional |
|
Type of Study
|
Other (Specify) [COMPARE OF ADDUCTOR CANAL BLOCK VS FEMORAL NERVE BLOCK TO ENHANCE RECOVERY AFTER TKA] |
| Study Design |
Other |
|
Public Title of Study
|
Comparison of two nerve block techniques for pain relief and recovery after knee replacement surgery |
|
Scientific Title of Study
|
Ultrasound-Guided Adductor Canal Block Versus Femoral Nerve Block for
Enhanced Recovery After Total Knee Arthroplasty : A Randomized
Controlled Trial. |
| Trial Acronym |
|
|
Secondary IDs if Any
|
| Secondary ID |
Identifier |
| NIL |
NIL |
|
|
Details of Principal Investigator or overall Trial Coordinator (multi-center study)
|
| Name |
Ajay Shankar |
| Designation |
PG Resident |
| Affiliation |
Raipur Institute Of Medical Sciences |
| Address |
Raipur Institute Of Medical Sciences Raipur Opp. NH6 Bhansoj Road Godhi 492101 Raipur Institute Of Medical Sciences Raipur Opp. NH6 Bhansoj Road Godhi 4921011 Raipur CHHATTISGARH 492101 India |
| Phone |
8770727747 |
| Fax |
|
| Email |
dr.ajayshankarpatel1996@gmail.com |
|
Details of Contact Person Scientific Query
|
| Name |
Ajay Shankar |
| Designation |
PG Resident |
| Affiliation |
Raipur Institute Of Medical Sciences |
| Address |
Raipur Institute Of Medical Sciences Raipur Opp. NH6 Bhansoj Road Godhi 492101 Raipur Institute Of Medical Sciences Raipur Opp. NH6 Bhansoj Road Godhi 492101 Raipur CHHATTISGARH 492101 India |
| Phone |
8770727747 |
| Fax |
|
| Email |
dr.ajayshankarpatel1996@gmail.com |
|
Details of Contact Person Public Query
|
| Name |
Ajay Shankar |
| Designation |
PG Resident |
| Affiliation |
Raipur Institute Of Medical Sciences |
| Address |
Raipur Institute Of Medical Sciences Raipur Opp. NH6 Bhansoj Road Godhi 492101 Raipur Institute Of Medical Sciences Raipur Opp. NH6 Bhansoj Road Godhi 492101 Raipur CHHATTISGARH 492101 India |
| Phone |
8770727747 |
| Fax |
|
| Email |
dr.ajayshankarpatel1996@gmail.com |
|
|
Source of Monetary or Material Support
|
| Raipur Institute Of Medical Sciences Raipur Opp. NH6 Bhansoj Road Godhi 492101 |
|
|
Primary Sponsor
|
| Name |
Ajay Shankar |
| Address |
Raipur Institute Of Medical Sciences Raipur Opp. NH6 Bhansoj Road Godhi 492101 |
| Type of Sponsor |
Other [self] |
|
|
Details of Secondary Sponsor
|
|
|
Countries of Recruitment
|
India |
|
Sites of Study
|
| No of Sites = 1 |
| Name of Principal
Investigator |
Name of Site |
Site Address |
Phone/Fax/Email |
| Dr Omprakash Aditya |
Raipur Institute Of Medical Sciences |
OT Complex,Third Floor,Raipur Institute Of Medical Sciences, Raipur, Bhansoj Road Godhi, Off NH6, C.G. 492101 Raipur CHHATTISGARH |
9340608451
adityaom2683@gmail.com |
|
|
Details of Ethics Committee
|
| No of Ethics Committees= 1 |
| Name of Committee |
Approval Status |
| INSTITUTIONAL ETHICS COMMITTEE |
Approved |
|
|
Regulatory Clearance Status from DCGI
|
|
|
Health Condition / Problems Studied
|
| Health Type |
Condition |
| Healthy Human Volunteers |
Patient Undergoing Elective Unilateral Knee Surgery |
| Patients |
, |
|
|
Intervention / Comparator Agent
|
| Type |
Name |
Details |
| Intervention |
Enhance Recovery Comparison Between Femoral Nerve Block Vrs Adductor Canal Block 0.5% Ropivacaine With Dexamethasone 4mg |
Ultrasound-guided Adductor Canal Block: High-frequency linear probe used at mid-thigh level
to identify femoral artery within adductor canal; 20 mL of 0.5% ropivacaine with 4 mg
Dexamethasone injected around the saphenous nerve |
| Intervention |
Enhance Recovery Comparison Between Femoral Nerve Block Vrs Adductor Canal Block 0.5% Ropivacaine With Dexamethasone 4mg |
Ultrasound-guided Femoral Nerve Block: Probe placed at inguinal crease to identify femoral nerve lateral to artery; 20 mL of 0.5% ropivacaine with Dexamethasone 4 mg injected around the nerve. |
| Comparator Agent |
Not Applicable |
Not Applicable |
|
|
Inclusion Criteria
|
| Age From |
18.00 Year(s) |
| Age To |
75.00 Year(s) |
| Gender |
Both |
| Details |
1.Patients of ASA status I and II.
2. Patient age between 18 and 75 years of age
3. Patients who gave consent for the study
4. Patients undergoing elective unilateral knee surgery |
|
| ExclusionCriteria |
| Details |
1. PATIENT WITH HISTORY OF CARDIOVASCULAR DISEAS
2. ALLERGY TO LOCAL ANAESTHESIA
3. INFECTION AT BLOCK SITE
4.COAGULOPATHY OR ANTICOAGULANT THERAPY
5. PATIENT ONANTI PSYCHOTIC MEDICATION |
|
|
Method of Generating Random Sequence
|
Computer generated randomization |
|
Method of Concealment
|
Other |
|
Blinding/Masking
|
|
|
Primary Outcome
|
| Outcome |
TimePoints |
| Post Operative Analgesia Quality, Need Of Rescue Analgesia Duration Of Analgesia, Total Rescue Analgesia Dose Required |
Post Operative Analgesia Quality, Need Of Rescue Analgesia Duration Of Analgesia, Total Rescue Analgesia Dose Required |
|
|
Secondary Outcome
|
| Outcome |
TimePoints |
| Quadriceps motor strength hemodynamic variability patient satisfaction & any adverse events |
2 hourly |
|
|
Target Sample Size
|
Total Sample Size="52" Sample Size from India="52"
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" |
|
Phase of Trial
|
Phase 4 |
|
Date of First Enrollment (India)
|
30/04/2026 |
| Date of Study Completion (India) |
Applicable only for Completed/Terminated trials |
| Date of First Enrollment (Global) |
Date Missing |
| Date of Study Completion (Global) |
Applicable only for Completed/Terminated trials |
|
Estimated Duration of Trial
|
Years="1" Months="6" Days="0" |
|
Recruitment Status of Trial (Global)
|
Not Yet Recruiting |
| Recruitment Status of Trial (India) |
Not Yet Recruiting |
|
Publication Details
|
N/A |
|
Individual Participant Data (IPD) Sharing Statement
|
Will individual participant data (IPD) be shared publicly (including data dictionaries)?
Response - NO
|
|
Brief Summary
|
Knee surgeries, particularly total knee arthroplasty (TKA), are associated with significant intraoperative and postoperative pain, which can hinder early mobilization and functional recovery. Traditionally, femoral nerve block (FNB) has been the cornerstone of regional anaesthesia techniques to manage pain after Total knee arthroplasty surgeries due to its efficacy in providing profound analgesia. However, its widespread use is often limited by the associated quadriceps motor weakness, which increases the risk of falls and delays postoperative mobilization . In recent years, the adductor canal block (ACB) has emerged as a motor-sparing alternative to FNB. The ACB primarily targets the saphenous nerve within the adductor canal, offering effective sensory blockade with minimal impact on quadriceps strength. Multiple studies and meta-analyses have highlighted the benefits of ACB in the postoperative setting, demonstrating comparable analgesic efficacy to FNB while preserving motor function and promoting earlier ambulation. Ultrasound guidance has significantly enhanced the precision, safety, and success rates of both FNB and ACB. However, literature evaluating these blocks for enhanced recovery after total knee arthroplasty is limited. For long, systemic opioids and NSAID have remained a mainstay of postoperative analgesia and recovery. Understanding the role of FNB and ACB for postoperative analgesia thereby facilitating the qualitative improvement in early recovery and mobilization after TKA surgeries is of paramount importance. Key goals of enhanced recovery after TKA surgery include: Reducing complications and surgical stress Optimizing pain management using multimodal, opioid-sparing techniques Promoting early mobilization and rehabilitation Shortening hospital stays and enabling a quicker return to normal function Improving overall patient satisfaction and outcomes This approach involves coordinated efforts between surgeons, anesthesiologists, physiotherapists, nurses, and patients. Components may include preoperative education, nutritional support, regional anesthesia, minimally invasive techniques, and early initiation of physiotherapy. This study aims to compare the efficacy of ultrasound-guided adductor canal block versus femoral nerve block when used for enhanced recovery in patients undergoing elective TKA surgeries. It seeks to determine which technique offers better analgesia, hemodynamic stability, and preservation of motor function during the postoperative phase |