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CTRI Number  CTRI/2026/04/108964 [Registered on: 21/04/2026] Trial Registered Prospectively
Last Modified On: 18/04/2026
Post Graduate Thesis  Yes 
Type of Trial  Interventional 
Type of Study   Other (Specify) [COMPARE OF ADDUCTOR CANAL BLOCK VS FEMORAL NERVE BLOCK TO ENHANCE RECOVERY AFTER TKA]  
Study Design  Other 
Public Title of Study   Comparison of two nerve block techniques for pain relief and recovery after knee replacement surgery 
Scientific Title of Study   Ultrasound-Guided Adductor Canal Block Versus Femoral Nerve Block for Enhanced Recovery After Total Knee Arthroplasty : A Randomized Controlled Trial. 
Trial Acronym   
Secondary IDs if Any  
Secondary ID  Identifier 
NIL  NIL 
 
Details of Principal Investigator or overall Trial Coordinator (multi-center study)  
Name  Ajay Shankar 
Designation  PG Resident 
Affiliation  Raipur Institute Of Medical Sciences 
Address  Raipur Institute Of Medical Sciences Raipur Opp. NH6 Bhansoj Road Godhi 492101
Raipur Institute Of Medical Sciences Raipur Opp. NH6 Bhansoj Road Godhi 4921011
Raipur
CHHATTISGARH
492101
India 
Phone  8770727747  
Fax    
Email  dr.ajayshankarpatel1996@gmail.com  
 
Details of Contact Person
Scientific Query
 
Name  Ajay Shankar 
Designation  PG Resident 
Affiliation  Raipur Institute Of Medical Sciences 
Address  Raipur Institute Of Medical Sciences Raipur Opp. NH6 Bhansoj Road Godhi 492101
Raipur Institute Of Medical Sciences Raipur Opp. NH6 Bhansoj Road Godhi 492101
Raipur
CHHATTISGARH
492101
India 
Phone  8770727747  
Fax    
Email  dr.ajayshankarpatel1996@gmail.com  
 
Details of Contact Person
Public Query
 
Name  Ajay Shankar 
Designation  PG Resident 
Affiliation  Raipur Institute Of Medical Sciences 
Address  Raipur Institute Of Medical Sciences Raipur Opp. NH6 Bhansoj Road Godhi 492101
Raipur Institute Of Medical Sciences Raipur Opp. NH6 Bhansoj Road Godhi 492101
Raipur
CHHATTISGARH
492101
India 
Phone  8770727747  
Fax    
Email  dr.ajayshankarpatel1996@gmail.com  
 
Source of Monetary or Material Support  
Raipur Institute Of Medical Sciences Raipur Opp. NH6 Bhansoj Road Godhi 492101 
 
Primary Sponsor  
Name  Ajay Shankar 
Address  Raipur Institute Of Medical Sciences Raipur Opp. NH6 Bhansoj Road Godhi 492101 
Type of Sponsor  Other [self] 
 
Details of Secondary Sponsor  
Name  Address 
NIL  NIL 
 
Countries of Recruitment     India  
Sites of Study  
No of Sites = 1  
Name of Principal Investigator  Name of Site  Site Address  Phone/Fax/Email 
Dr Omprakash Aditya  Raipur Institute Of Medical Sciences  OT Complex,Third Floor,Raipur Institute Of Medical Sciences, Raipur, Bhansoj Road Godhi, Off NH6, C.G. 492101
Raipur
CHHATTISGARH 
9340608451

adityaom2683@gmail.com 
 
Details of Ethics Committee  
No of Ethics Committees= 1  
Name of Committee  Approval Status 
INSTITUTIONAL ETHICS COMMITTEE  Approved 
 
Regulatory Clearance Status from DCGI  
Status 
Not Applicable 
 
Health Condition / Problems Studied  
Health Type  Condition 
Healthy Human Volunteers  Patient Undergoing Elective Unilateral Knee Surgery 
Patients  ,  
 
Intervention / Comparator Agent  
Type  Name  Details 
Intervention  Enhance Recovery Comparison Between Femoral Nerve Block Vrs Adductor Canal Block 0.5% Ropivacaine With Dexamethasone 4mg  Ultrasound-guided Adductor Canal Block: High-frequency linear probe used at mid-thigh level to identify femoral artery within adductor canal; 20 mL of 0.5% ropivacaine with 4 mg Dexamethasone injected around the saphenous nerve 
Intervention  Enhance Recovery Comparison Between Femoral Nerve Block Vrs Adductor Canal Block 0.5% Ropivacaine With Dexamethasone 4mg  Ultrasound-guided Femoral Nerve Block: Probe placed at inguinal crease to identify femoral nerve lateral to artery; 20 mL of 0.5% ropivacaine with Dexamethasone 4 mg injected around the nerve. 
Comparator Agent  Not Applicable  Not Applicable 
 
Inclusion Criteria  
Age From  18.00 Year(s)
Age To  75.00 Year(s)
Gender  Both 
Details  1.Patients of ASA status I and II.
2. Patient age between 18 and 75 years of age
3. Patients who gave consent for the study
4. Patients undergoing elective unilateral knee surgery 
 
ExclusionCriteria 
Details  1. PATIENT WITH HISTORY OF CARDIOVASCULAR DISEAS
2. ALLERGY TO LOCAL ANAESTHESIA
3. INFECTION AT BLOCK SITE
4.COAGULOPATHY OR ANTICOAGULANT THERAPY
5. PATIENT ONANTI PSYCHOTIC MEDICATION 
 
Method of Generating Random Sequence   Computer generated randomization 
Method of Concealment   Other 
Blinding/Masking    
Primary Outcome  
Outcome  TimePoints 
Post Operative Analgesia Quality, Need Of Rescue Analgesia Duration Of Analgesia, Total Rescue Analgesia Dose Required  Post Operative Analgesia Quality, Need Of Rescue Analgesia Duration Of Analgesia, Total Rescue Analgesia Dose Required 
 
Secondary Outcome  
Outcome  TimePoints 
Quadriceps motor strength hemodynamic variability patient satisfaction & any adverse events  2 hourly 
 
Target Sample Size   Total Sample Size="52"
Sample Size from India="52" 
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" 
Phase of Trial   Phase 4 
Date of First Enrollment (India)   30/04/2026 
Date of Study Completion (India) Applicable only for Completed/Terminated trials 
Date of First Enrollment (Global)  Date Missing 
Date of Study Completion (Global) Applicable only for Completed/Terminated trials 
Estimated Duration of Trial   Years="1"
Months="6"
Days="0" 
Recruitment Status of Trial (Global)   Not Yet Recruiting 
Recruitment Status of Trial (India)  Not Yet Recruiting 
Publication Details   N/A 
Individual Participant Data (IPD) Sharing Statement

Will individual participant data (IPD) be shared publicly (including data dictionaries)?  

Response - NO
Brief Summary  

Knee surgeries, particularly total knee arthroplasty (TKA), are associated with significant intraoperative and postoperative pain, which can hinder early mobilization and functional recovery. Traditionally, femoral nerve block (FNB) has been the cornerstone of regional anaesthesia techniques to manage pain after Total knee arthroplasty surgeries due to its efficacy in providing profound analgesia. However, its widespread use is often limited by the associated quadriceps motor weakness, which increases the risk of falls and delays postoperative mobilization .

In recent years, the adductor canal block (ACB) has emerged as a motor-sparing alternative to FNB. The ACB primarily targets the saphenous nerve within the adductor canal, offering effective sensory blockade with minimal impact on quadriceps strength. Multiple studies and meta-analyses have highlighted the benefits of ACB in the postoperative setting, demonstrating comparable analgesic efficacy to FNB while preserving motor function and promoting earlier ambulation.

Ultrasound guidance has significantly enhanced the precision, safety, and success rates of both FNB and ACB. However, literature evaluating these blocks for enhanced recovery after total knee arthroplasty is limited. For long, systemic opioids and NSAID have remained a mainstay of postoperative analgesia and recovery. Understanding the role of FNB and ACB for postoperative analgesia thereby facilitating the qualitative improvement in early recovery and mobilization after TKA surgeries is of paramount importance.

Key goals of enhanced recovery after TKA surgery include:

Reducing complications and surgical stress

Optimizing pain management using multimodal, opioid-sparing techniques

 Promoting early mobilization and rehabilitation

Shortening hospital stays and enabling a quicker return to normal function

 Improving overall patient satisfaction and outcomes

 

This approach involves coordinated efforts between surgeons, anesthesiologists, physiotherapists, nurses, and patients. Components may include preoperative education, nutritional support, regional anesthesia, minimally invasive techniques, and early initiation of physiotherapy.

 This study aims to compare the efficacy of ultrasound-guided adductor canal block versus

femoral nerve block when used for enhanced recovery in patients undergoing elective TKA
surgeries. It seeks to determine which technique offers better analgesia, hemodynamic
stability, and preservation of motor function during the postoperative phase
 
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