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CTRI Number  CTRI/2026/01/100206 [Registered on: 02/01/2026] Trial Registered Prospectively
Last Modified On: 08/01/2026
Post Graduate Thesis   
Type of Trial  Interventional 
Type of Study   Dentistry 
Study Design  Randomized, Parallel Group, Placebo Controlled Trial 
Public Title of Study   Effect of Chlorhexidine gel coated silk suture in wound healing after wisdom tooth removal 
Scientific Title of Study   comparative assessment of wound healing between incisions closed with conventional 3 0 silk suture and 3 0 silk suture coated with 0.2 percent chlorhexidine gel an in vivo study 
Trial Acronym  nil 
Secondary IDs if Any  
Secondary ID  Identifier 
NIL  NIL 
 
Details of Principal Investigator or overall Trial Coordinator (multi-center study)  
Name  Hemamalini S 
Designation  Resident intern 
Affiliation  Tagore dental college and hospital 
Address  Department of oral and maxillofacial surgery room no 3 Tagore dental college and hospital Rathinamangalam melakottaiyur post chennai 600127

Kancheepuram
TAMIL NADU
600127
India 
Phone  7305504519  
Fax    
Email  hemamalinisureshkumar117@gmail.com  
 
Details of Contact Person
Scientific Query  
Name  Dr Israel Nathaneal 
Designation  Associate professor 
Affiliation  Tagore dental college and hospital 
Address  Deparment of oral and maxillofacial surgery room no 3 Tagore dental college and hospital Rathinamangalam Melakottaiyur post chennai 600127

Kancheepuram
TAMIL NADU
600127
India 
Phone  93803363737  
Fax    
Email  israel@tagoredch.in  
 
Details of Contact Person
Public Query  
Name  Dr Israel Nathaneal 
Designation  Associate professor 
Affiliation  Tagore dental college and hospital 
Address  Deparment of oral and maxillofacial surgery room no 3 Tagore dental college and hospital Rathinamangalam Melakottaiyur post chennai 600127

Kancheepuram
TAMIL NADU
600127
India 
Phone  93803363737  
Fax    
Email  israel@tagoredch.in  
 
Source of Monetary or Material Support  
Nil 
 
Primary Sponsor  
Name  Hemamalini S 
Address  Tagore dental college and hospital Rathinamangalam melakottaiyur post chennai 600127 
Type of Sponsor  Other [self] 
 
Details of Secondary Sponsor  
Name  Address 
NIL  NIL 
 
Countries of Recruitment     India  
Sites of Study  
No of Sites = 1  
Name of Principal Investigator  Name of Site  Site Address  Phone/Fax/Email 
Dr Israel Nathaneal  Tagore dental college and hospital   Department of oral and maxillofacial surgery room 3
Kancheepuram
TAMIL NADU 		 93803363737

israel@tagoredch.in 
 
Details of Ethics Committee  
No of Ethics Committees= 1  
Name of Committee  Approval Status 
Institutional ethics committee  Approved 
 
Regulatory Clearance Status from DCGI  
Status 
Not Applicable 
 
Health Condition / Problems Studied  
Health Type  Condition 
Healthy Human Volunteers  nil 
 
Intervention / Comparator Agent  
Type  Name  Details 
Intervention  0.2 percent chlorhexidine gel  After the surgical removal of 3rd molar relieving incision closure done using 3-0 silk suture coated with 0.2 percent chlorhexidine gel.contact time is 7 days 0.2% chlorhexidine gel was prepared by diluting commercially available 2% chlorhexidine gel in a 1:9 ratio using a saline. The dilution was performed under aseptic conditions using a sterile disposable 10-ml syringe without a needle by gently pushing and pulling the plunger several times. The prepared gel was applied uniformly to the silk suture 2 hour prior to surgery.  
Comparator Agent  3 0 silk suture   after removal of 3rd molar releiving incision closed with 3 0 silk suture.standard care given 
 
Inclusion Criteria  
Age From  20.00 Year(s)
Age To  40.00 Year(s)
Gender  Both 
Details  healthy patients aged 20-40 years
third molar region unilateral class 1 and 2 and position A and B
vertical and mesioangular impaction
patient willing to participate in the study
patient posted for surgical removal of mandibular 3rd molar 
 
ExclusionCriteria 
Details  patient with systemic disease affecting wound healing
patient allergic to chlorhexidine
infected or contaminated surgical site
patient not willing to participate 
 
Method of Generating Random Sequence   Computer generated randomization 
Method of Concealment   An Open list of random numbers 
Blinding/Masking   Participant and Investigator Blinded 
Primary Outcome  
Outcome  TimePoints 
Assessment of wound healing of the surgical site and pain using a standardized wound healing index at specified postoperative intervals  wound healing was assessed on day 1 day 3 day 7 
 
Secondary Outcome  
Outcome  TimePoints 
swelling  day1,day3,day7 
 
Target Sample Size   Total Sample Size="54"
Sample Size from India="54" 
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" 
Phase of Trial   N/A 
Date of First Enrollment (India)   19/01/2026 
Date of Study Completion (India) Applicable only for Completed/Terminated trials 
Date of First Enrollment (Global)  Date Missing 
Date of Study Completion (Global) Applicable only for Completed/Terminated trials 
Estimated Duration of Trial   Years="0"
Months="0"
Days="1" 
Recruitment Status of Trial (Global)   Not Yet Recruiting 
Recruitment Status of Trial (India)  Not Yet Recruiting 
Publication Details   N/A 
Individual Participant Data (IPD) Sharing Statement

Will individual participant data (IPD) be shared publicly (including data dictionaries)?  

Response - NO
Brief Summary
Modification(s)  		 This study is randomized clinical trial designed to compare wound healing following surgical extraction in incision closure using conventional 3 0 silk suture and 3 0 silk sutures coated with chlorhexidine gel. A total of 54 participants will be randomly allocated into two groups. In the intervention group surgical wounds will be closed using 3 0 silk sutures coated with 0.2 percent chlorhexidine gel. In the control group wound closure will be done using conventional 3 0 silk sutures. Wound healing will be assessed using a standardized wound healing index Landry’s healing index on day 1 and postoperative day 3 and 7.The data collection will be done for 3 weeks. The study aims to evaluate the effectiveness of chlorhexidine coated silk sutures in improving wound healing outcomes. 
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