| CTRI Number |
CTRI/2026/04/108435 [Registered on: 15/04/2026] Trial Registered Prospectively |
| Last Modified On: |
15/04/2026 |
| Post Graduate Thesis |
No |
| Type of Trial |
Interventional |
|
Type of Study
|
Physiotherapy (Not Including YOGA) |
| Study Design |
Single Arm Study |
|
Public Title of Study
|
Effect of Multi-Directional Exercise Training on Leg Strength and Daily Activities in People with Knee Osteoarthritis |
|
Scientific Title of Study
|
Effect of Short-Term Multi-Plane Kinetic Chain Training on Quadriceps Strength and Functional Performance in Knee Osteoarthritis |
| Trial Acronym |
NIL |
|
Secondary IDs if Any
|
| Secondary ID |
Identifier |
| Nil |
NIL |
|
|
Details of Principal Investigator or overall Trial Coordinator (multi-center study)
|
| Name |
ABHINAY PATEL |
| Designation |
STUDENT |
| Affiliation |
SRM college of physiotherapy, SRMIST, Kattankulathur |
| Address |
Room no.PT29,4th floor,SRM college of Physiotherapy,SRM medical college hospital and Research centre,SRMIST, Kattankankulathur
Chennai
TAMIL NADU
603203
Kancheepuram
TAMIL NADU
603203
India |
| Phone |
7903639551 |
| Fax |
|
| Email |
ap3485@srmist.edu.in |
|
Details of Contact Person
Scientific Query
|
| Name |
ABHINAY PATEL |
| Designation |
STUDENT |
| Affiliation |
SRM college of physiotherapy, SRMIST, Kattankulathur |
| Address |
Room no.PT05, 5th floor,SRM college of Physiotherapy,SRM medical college hospital and Research centre,SRMIST, Kattankankulathur
Chennai
TAMIL NADU
603203
INDIA
Room no.PT05, 5th floor,SRM college of Physiotherapy,SRM medical college hospital and Research centre,SRMIST, Kattankankulathur
Chennai
TAMIL NADU
603203
INDIA
Kancheepuram
TAMIL NADU
603203
India |
| Phone |
7903639551 |
| Fax |
|
| Email |
ap3485@srmist.edu.in |
|
Details of Contact Person
Public Query
|
| Name |
ABHINAY PATEL |
| Designation |
STUDENT |
| Affiliation |
SRM college of physiotherapy, SRMIST, Kattankulathur |
| Address |
Room no.PT29,4th floor,SRM college of Physiotherapy,SRM medical college hospital and Research centre,SRMIST, Kattankankulathur
Chennai
TAMIL NADU
603203
Kancheepuram
TAMIL NADU
603203
India |
| Phone |
7903639551 |
| Fax |
|
| Email |
ap3485@srmist.edu.in |
|
|
Source of Monetary or Material Support
|
|
|
Primary Sponsor
|
| Name |
ABHINAY PATEL |
| Address |
Room no.PT 05th floor,SRM college of Physiotherapy, SRM medical college hospital and Research centre, SRMIST, Kattankankulathur
Chennai
TAMIL NADU
603203
India |
| Type of Sponsor |
Research institution and hospital |
|
|
Details of Secondary Sponsor
|
|
|
Countries of Recruitment
|
India |
|
Sites of Study
|
| No of Sites = 1 |
| Name of Principal
Investigator |
Name of Site |
Site Address |
Phone/Fax/Email |
| ABHINAY PATEL |
SRM COLLEGE OF PHYSIOTHERAPY |
SRM Medical College Hospital and Research Center, Kancheepuram, Tamil Nadu
Kancheepuram
TAMIL NADU |
7903639551
ap3485@srmist.edu.in |
|
|
Details of Ethics Committee
|
| No of Ethics Committees= 1 |
| Name of Committee |
Approval Status |
| SRM MEDICAL COLLEGE AND RESEARCH CENTER INSTITUTIONAL ETHICS COMMITTEE |
Approved |
|
|
Regulatory Clearance Status from DCGI
|
|
|
Health Condition / Problems Studied
|
| Health Type |
Condition |
| Patients |
(1) ICD-10 Condition: M170||Bilateral primary osteoarthritis of knee, (2) ICD-10 Condition: M179||Osteoarthritis of knee, unspecified, |
|
|
Intervention / Comparator Agent
|
| Type |
Name |
Details |
| Comparator Agent |
NIL |
NIL |
| Intervention |
Short-term multi-plane kinetic chain training on quadriceps strength and functional performance in knee osteoarthritis |
After the selection of participants using inclusion and exclusion criteria pre assessment will be taken to assess the quadriceps strength and functional performance and training protocol will be given and after the period of training post assessment will be taken after 4 weeks and with values of pre and post-test will be able to know the effectiveness of intervention |
|
|
Inclusion Criteria
|
| Age From |
35.00 Year(s) |
| Age To |
55.00 Year(s) |
| Gender |
Both |
| Details |
Age group above 35 years and above.
Osteoarthritis patients.
Both male and female willingness to participate. |
|
| ExclusionCriteria |
| Details |
Severe knee osteoarthritis (Kellgren– Lawrence Grade IV).
History of knee surgery, fracture, or recent injury in the lower limb (within the past
6 months).
Neurological disorders affecting balance or muscle strength.
Rheumatoid arthritis, inflammatory joint disease, or systemic conditions affecting
joints.
Uncontrolled hypertension, diabetes, or other medical conditions preventing
participation in exercise. |
|
|
Method of Generating Random Sequence
|
Stratified block randomization |
|
Method of Concealment
|
Case Record Numbers |
|
Blinding/Masking
|
Participant Blinded |
|
Primary Outcome
|
| Outcome |
TimePoints |
Quadriceps muscle strength, Functional endurance (TUG Test),
Functional Ability and quality of life (KOOS) |
4 weeks |
|
|
Secondary Outcome
|
| Outcome |
TimePoints |
| Pain (NPRS) |
4 weeks |
|
|
Target Sample Size
|
Total Sample Size="30"
Sample Size from India="30"
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" |
|
Phase of Trial
|
N/A |
|
Date of First Enrollment (India)
|
29/04/2026 |
| Date of Study Completion (India) |
Applicable only for Completed/Terminated trials |
| Date of First Enrollment (Global) |
Date Missing |
| Date of Study Completion (Global) |
Applicable only for Completed/Terminated trials |
|
Estimated Duration of Trial
|
Years="0"
Months="1"
Days="28" |
|
Recruitment Status of Trial (Global)
|
Not Yet Recruiting |
| Recruitment Status of Trial (India) |
Not Yet Recruiting |
|
Publication Details
|
N/A |
|
Individual Participant Data (IPD) Sharing Statement
|
Will individual participant data (IPD) be shared publicly (including data dictionaries)?
Response - NO
|
|
Brief Summary
|
Short-term multi-plane kinetic chain training has been shown to be effective in improving outcomes in individuals with Knee Osteoarthritis. This type of training involves performing functional, weight-bearing exercises across multiple planes of movement—sagittal, frontal, and transverse—such as squats, lunges, and step-ups, which closely mimic daily activities. Over a short duration, typically 4 weeks, this approach significantly enhances quadriceps muscle strength, improves functional performance as measured by tests like the Timed Up and Go (TUG), and reduces pain levels assessed using the Numeric Pain Rating Scale (NPRS). The improvements are attributed to better neuromuscular coordination, joint stability, and activation of multiple muscle groups. Overall, multi-plane kinetic chain training is considered a practical and effective rehabilitation strategy for improving mobility, strength, and quality of life in patients with knee osteoarthritis. |