This study will be conducted to evaluate and compare the clinical and radiographic outcomes of two root canal filling materials, zinc oxide–ozonated oil and Endoflas, in pulpectomy procedures performed in primary molars. Pulpectomy is commonly indicated in primary teeth with irreversible pulpitis or necrotic pulp; however, the ideal obturating material should possess antimicrobial properties, biocompatibility, and the ability to resorb in harmony with the physiological root resorption of primary teeth.

In this randomized clinical trial, children requiring pulpectomy in primary molars will be recruited and randomly allocated into two groups. Following standard biomechanical preparation of the root canals, the canals will be obturated with either zinc oxide–ozonated oil or Endoflas according to the assigned group.

The treated teeth will be evaluated for clinical and radiographic success at predetermined follow-up intervals of 3, 6, and 9 months. Clinical parameters such as pain, swelling, sinus tract, abnormal mobility, and tenderness to percussion will be assessed, while radiographic evaluation will include assessment of periapical or furcation radiolucency, pathological root resorption, and signs of healing.

The findings of this study will help determine whether zinc oxide–ozonated oil can serve as an effective alternative to Endoflas as an obturating material in pulpectomy of primary molars.