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CTRI Number  CTRI/2026/03/105622 [Registered on: 09/03/2026] Trial Registered Prospectively
Last Modified On: 07/03/2026
Post Graduate Thesis  Yes 
Type of Trial  Interventional 
Type of Study   Drug
Ayurveda 
Study Design  Randomized, Parallel Group, Active Controlled Trial 
Public Title of Study   A Study Comparing Kantkari Ghrita and Vasa Avaleha for Treating Cough in Children 
Scientific Title of Study   A comparitive clinical study to evaluate the efficacy of kantkari ghrita and vasavleha,in the management of kasa w.s.r cough in children due to varied etiology. 
Trial Acronym  NIL 
Secondary IDs if Any  
Secondary ID  Identifier 
NIL  NIL 
 
Details of Principal Investigator or overall Trial Coordinator (multi-center study)  
Name  Dr Nikhil Kataria 
Designation  PG Scholar 
Affiliation  Shri Dhanwantri Ayurvedic medical college & Research Centre  
Address  Department of pediatrics, Shri Dhanwantri Ayurvedic medical college and Research Centre, Chhata,Mathura.

Mathura
UTTAR PRADESH
281401
India 
Phone  9464939847  
Fax    
Email  nikhilkataria847@gmail.com  
 
Details of Contact Person
Scientific Query  
Name  Prof Dr Ritesh Murlidhar Kela  
Designation  Professor , H.O.D 
Affiliation  Shri Dhanwantri Ayurvedic medical college & Research Centre  
Address  Department of pediatrics, Shri Dhanwantri Ayurvedic medical college and Research Centre , Chhata,Mathura.

Mathura
UTTAR PRADESH
281401
India 
Phone  9881259158  
Fax    
Email  drriteshkela@gmail.com  
 
Details of Contact Person
Public Query  
Name  Prof Dr Ritesh Murlidhar Kela  
Designation  Professor , H.O.D 
Affiliation  Shri Dhanwantri Ayurvedic medical college & Research Centre  
Address  Department of pediatrics, Shri Dhanwantri Ayurvedic medical college and Research Centre , Chhata,Mathura.

Mathura
UTTAR PRADESH
281401
India 
Phone  9881259158  
Fax    
Email  drriteshkela@gmail.com  
 
Source of Monetary or Material Support  
Shri Dhanwantri Ayurvedic medical college and Research Centre,Mathura , Uttar Pradesh, India , 281401 
 
Primary Sponsor  
Name  Shri Dhanwantri Ayurvedic medical college Research Centre  
Address  Shri Dhanwantri Ayurvedic medical college & Research Centre,Chhata,Mathura , Uttar Pradesh , India 281401  
Type of Sponsor  Research institution and hospital 
 
Details of Secondary Sponsor  
Name  Address 
NIL  NIL 
 
Countries of Recruitment     India  
Sites of Study  
No of Sites = 1  
Name of Principal Investigator  Name of Site  Site Address  Phone/Fax/Email 
Dr Nikhil Kataria  Shri Dhanwantri Ayurvedic medical college and Research Centre   Department of Kaumarbhritya , First Floor , Shri Dhanwantri Ayurvedic medical college and Research Centre, Chhata, Mathura , 281401
Mathura
UTTAR PRADESH 		 9464939847

nikhilkataria847@gmail.com 
 
Details of Ethics Committee  
No of Ethics Committees= 1  
Name of Committee  Approval Status 
IEC,Shri Dhanwantri Ayurvedic Medical College and Research centre,Mathura   Approved 
 
Regulatory Clearance Status from DCGI  
Status 
Not Applicable 
 
Health Condition / Problems Studied  
Health Type  Condition 
Patients  (1) ICD-10 Condition:J00-J99||Diseases of the respiratory system. Ayurveda Condition: KASAH,  
 
Intervention / Comparator Agent  
snoIntervention/ComparatorTypeDrug-TypeProcedure NameDetails
1Intervention ArmDrugClassical(1) Medicine Name: Kantkari Ghrita, Reference: Bhaishajya Ratnawali, Route: Oral, Dosage Form: Ghrita, Dose: 5(ml), Frequency: bd, Bhaishajya Kal: Abhakta, Duration: 4 Weeks, anupAna/sahapAna: Yes(details: -Koshana jala , Dughda), Additional Information: -
2Comparator ArmDrugClassical(1) Medicine Name: Vasa avleha, Reference: Bhaishajya Ratnavali, Route: Oral, Dosage Form: Avleha/Leha/Paka/Raskriya, Dose: 6(g), Frequency: bd, Bhaishajya Kal: Abhakta, Duration: 4 Weeks, anupAna/sahapAna: Yes(details: -Koshana jala , Dughda), Additional Information: -
 
Inclusion Criteria  
Age From  5.00 Year(s)
Age To  12.00 Year(s)
Gender  Both 
Details  1. Patients with classical features of kasa roga
2. Patients having cough less than 1 month
3. The selection of the patients will be irrespective of sex , religion or socio economic status 
 
ExclusionCriteria 
Details  1. Patients presenting with symptoms of Tamak shwasa (Bronchial Asthma) , Kshayaja , and Kshataja Kasa
2. Serious Cardiovascular , Cerebrovascular , Renal and Liver diseases or severe illness
3. Any chronic illness diseases of Respiratory system example TB , Respiratory Distress syndrome , Chronic Lung disease , Bronchiectasis, Pleurisy etc.
4. Patients suffering from any systemic disorder and kasa as complication of any disease will be excluded from the study
5. Children with any congenital abnormality
6. History of food , Drug allergy of any kind
7. During course of treatment if the subject develops any acute illness requiring acute management , such patients will be excluded out of the study and continued with conventional treatment
8. Patient below age of 5 years and above 12 years  
 
Method of Generating Random Sequence   Coin toss, Lottery, toss of dice, shuffling cards etc 
Method of Concealment   Alternation 
Blinding/Masking   Open Label 
Primary Outcome  
Outcome  TimePoints 
1. Improvement in subjective symptoms
2. Reduction in cough severity
 		 Follow up after 1 week
 
 
Secondary Outcome  
Outcome  TimePoints 
1. Improvement in associated symptoms
2. Quality of life
3. Safety and tolerability 		 Follow up after 1 week 
 
Target Sample Size   Total Sample Size="50"
Sample Size from India="50" 
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" 
Phase of Trial   Phase 2/ Phase 3 
Date of First Enrollment (India)   25/03/2026 
Date of Study Completion (India) Applicable only for Completed/Terminated trials 
Date of First Enrollment (Global)  Date Missing 
Date of Study Completion (Global) Applicable only for Completed/Terminated trials 
Estimated Duration of Trial   Years="0"
Months="0"
Days="28" 
Recruitment Status of Trial (Global)   Not Applicable 
Recruitment Status of Trial (India)  Not Yet Recruiting 
Publication Details   N/A 
Individual Participant Data (IPD) Sharing Statement

Will individual participant data (IPD) be shared publicly (including data dictionaries)?  

Response - NO
Brief Summary  
Introduction
 ’Kasa’ word is derived from the root "kasri" i.e. "shabda- kutsanyam" which
means "Unpleasant sound".
Gangadhar, the commentator describes ’Kasa’ from the dhatu "kasri" which
means "bhirnnaswara".
 Commentator Chakrapani derived the word ’ Kasa’ from the root i.e. "gati -
Shatanayoh" which means "falling movement" . In Kantha both reflex
activities of Prana and Udana Vayu require co-ordinate action.
 Kasa is one of the common complaint in day to day Paediatric Practice.
 Kasa is an independent disease as well as symptom of diseases.
 The etiology of Hikka, Swasa and Kasa are same but samprapties are different.
Kasa is also nidhanarthkar roga of some diseases.
 Acharya Charaka defines Kasa as release of obstructed Vayu resulting in the
production of abnormal sound in the process which may be productive or dry.• Chakrapani dutta has commented on the word Kasa as the drawing of chest wall
(Ura) during coughing .
 Acharaya Sushruta defined Kasa as the disease associated with a typical sound
similar to sound obtained from broken bronze vessel.
 Kasa is the most frequentely encountered problem in the Balyavastha (paediatric
age) Since Kapha is the main culprit in production of Kasa (cough) and kapha
dosha is dominating in Balyavastha .
 The incidence is more in this age group . Early intervention is necessary in case of
Kasa ’ as it may produce kshaya (Tuberculosis)
 In Bhaishajaya Ratnawali Kasa roga Chikitsa prakran, Vasa avleha and in
Bhaishajaya Ratnawali Kasa roga Chikitsa prakran Kantkari Ghrita are indicated
for the management of Kasa roga.
 Therefore, it is decided to evaluate the clinical study of both yogas in the
management of Kasa roga in children.

Research Question
Are the classical Ayurvedic preparations Kantkari Ghrita & Vasavleha,
effective in the management of Kasa w.s.r. to cough in children ?


Material and Method
The study design is as follows
Study type – Interventional
Sub-type – comparative study
Purpose - treatment
Timing – prospective
Masking - open trial
Sampling method - simple randomized method
End point – efficacy
Sample size - 50(25 in each group)
Number of groups - 2 groups
Group A- Kantkari Ghrita
Group B – Vasa Avaleha
Selection of cases - OPD/IPD
Sample population - patients from Shri Dhanwantri Ayurvedic Medical College
& Research Centre , Mathura (U.P)
Duration of trial - 4 weeks
Follow up - After every one week 
 
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