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CTRI Number  CTRI/2026/04/107544 [Registered on: 02/04/2026] Trial Registered Prospectively
Last Modified On: 24/03/2026
Post Graduate Thesis  No 
Type of Trial  Interventional 
Type of Study   Drug
Surgical/Anesthesia 
Study Design  Other 
Public Title of Study   Comparing ultrasound guided peripheral nerve group block and ultrasound guided femoral nerve block for the ease of positioning for central neuraxial blockade in patients of proximal segment femur fracture surgeries. 
Scientific Title of Study   Peripheral Nerve Group Block Vs Femoral Nerve Block For Analgesia and Positioning in Proximal Femur Fractures: A Randomised Controlled Comparison 
Trial Acronym   
Secondary IDs if Any  
Secondary ID  Identifier 
NIL  NIL 
 
Details of Principal Investigator or overall Trial Coordinator (multi-center study)  
Name  Dr Rangoli Sao 
Designation  Junior Resident 
Affiliation  N K P Salve Institue of Medical Sciences and Research Centre. 
Address  Department of Anaesthesiology, NKP Salve Institute of Medical Sciences and Research Centre and Lata Mangeshkar Hospital Digdoh Hills, Hingne Road.

Nagpur
MAHARASHTRA
440019
India 
Phone  9527241249  
Fax    
Email  rangolisao174@gmail.com  
 
Details of Contact Person
Scientific Query
 
Name  Dr Heena Pahuja 
Designation  Professor 
Affiliation  N K P Salve Institue of Medical Sciences and Research Centre. 
Address  Department of Anaesthesiology, NKP Salve Institute of Medical Sciences and Research Centre and Lata Mangeshkar Hospital Digdoh Hills, Hingne Road.

Nagpur
MAHARASHTRA
440019
India 
Phone  9823188160  
Fax    
Email  heenapahuja15@yahoo.com  
 
Details of Contact Person
Public Query
 
Name  Dr Heena Pahuja 
Designation  Professor 
Affiliation  N K P Salve Institue of Medical Sciences and Research Centre. 
Address  Department of Anaesthesiology, NKP Salve Institute of Medical Sciences and Research Centre and Lata Mangeshkar Hospital Digdoh Hills, Hingne Road.

Nagpur
MAHARASHTRA
440019
India 
Phone  9823188160  
Fax    
Email  heenapahuja15@yahoo.com  
 
Source of Monetary or Material Support  
NIL 
 
Primary Sponsor  
Name  Dr Rangoli Sao 
Address  NKP Salve Institute of Medical Sciences and Research Centre and Lata Mangeshkar Hospital Digdoh Hills, Hingne Road, Nagpur, Maharastra 440019 
Type of Sponsor  Private medical college 
 
Details of Secondary Sponsor  
Name  Address 
NIL  NIL 
 
Countries of Recruitment     India  
Sites of Study  
No of Sites = 1  
Name of Principal Investigator  Name of Site  Site Address  Phone/Fax/Email 
Rangoli Sao  NKP Salve Institute of Medical sciences and Research Centre and Lata Mangeshkar Hospital   Department of anaesthesiology, orthopaedics Operation theartre ,NKP Salve Institute of Medical sciences and Research Centre and Lata Mangeshkar Hospital digdoh hills hingna road Nagpur
Nagpur
MAHARASHTRA 
9527241249

rangolisao174@gmail.com 
 
Details of Ethics Committee  
No of Ethics Committees= 1  
Name of Committee  Approval Status 
Instituional Ethics Committee N K P Salve Institute of Medical Sciences and Research Centre and Lata Mangeshkar Hospital Nagpur  Approved 
 
Regulatory Clearance Status from DCGI  
Status 
Not Applicable 
 
Health Condition / Problems Studied  
Health Type  Condition 
Patients  (1) ICD-10 Condition: S729||Unspecified fracture of femur, (2) ICD-10 Condition: O||Medical and Surgical,  
 
Intervention / Comparator Agent  
Type  Name  Details 
Comparator Agent  Ultrasound Guided Femoral Block   USG FNB will be given on the operating side (lower limb) with injection Ropivacaine 0.2 percent 15 cc. after that NRS score of the patient will be recorded and compared with the intervention group. 
Intervention  Ultrasound Guided Peripheral Nerve Group Block   USG PENG block will be given on the operating side (lower limb) with injection Ropivacaine 0.2percent 15 ml. after that NRS score will be recorded of the patient and compared with the comparison group. 
 
Inclusion Criteria  
Age From  18.00 Year(s)
Age To  80.00 Year(s)
Gender  Both 
Details  posted for proximal segment femur fracture surgeries
patient oriented to time, place, person
ASA grade I, II, III 
 
ExclusionCriteria 
Details   
 
Method of Generating Random Sequence   Not Applicable 
Method of Concealment   Not Applicable 
Blinding/Masking   Participant and Outcome Assessor Blinded 
Primary Outcome  
Outcome  TimePoints 
There is statistically significant difference between the decrease of NRS for ultrasound guided peripheral nerve block compared to ultrasound guided femoral nerve block in proximal segment femur fracture patients. Also there was significant difference in the patient satisfaction and anaesthesiologist satisfaction score at 30 mins of the block with better satisfaction in PENG block compared to FNB.  There is statistically significant difference between the decrease of NRS for ultrasound guided peripheral nerve block compared to ultrasound guided femoral nerve block in proximal segment femur fracture patients at 0 mins, 10 mins, 20 mins, 30 mins.  
 
Secondary Outcome  
Outcome  TimePoints 
postoperative analgesia in first 24 hours after the block was better in PENG( intervention group) compared to FNB (comparison group). also haemodynamic stability was better at 0 min, 10 min, 20 min & 30 min in PENG group compared to FNB group. Quadricep muscles were spared in PENG block & the patient was able to lift the operating leg by 15 degrees after 30 mins of the block before central neuraxial blockade.  haemodynamic stability was seen at 0mins, 10 mins, 20 mins, 30 mins. quadricep muscle power was seen at 30 mins of the block & post operative analgesia was seen for first 24 hours of the block. 
 
Target Sample Size   Total Sample Size="52"
Sample Size from India="52" 
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" 
Phase of Trial   N/A 
Date of First Enrollment (India)   06/04/2026 
Date of Study Completion (India) Applicable only for Completed/Terminated trials 
Date of First Enrollment (Global)  Date Missing 
Date of Study Completion (Global) Applicable only for Completed/Terminated trials 
Estimated Duration of Trial   Years="1"
Months="0"
Days="0" 
Recruitment Status of Trial (Global)   Not Applicable 
Recruitment Status of Trial (India)  Not Yet Recruiting 
Publication Details   N/A 
Individual Participant Data (IPD) Sharing Statement

Will individual participant data (IPD) be shared publicly (including data dictionaries)?  

Response - NO
Brief Summary  

Effective pain management is essential for ensuring optimal positioning during spinal anesthesia, especially in complex surgeries such as proximal femur fracture procedures. Proper positioning is critical for the accurate placement of the spinal needle and the overall effectiveness of the block. When patients are in discomfort, they may struggle to maintain the required posture—whether sitting or lying in a specific position—which can compromise the precision of needle placement. Effective pain control before positioning for CNB alleviates this discomfort, allowing patients to remain still and maintain the correct position, which is crucial for a successful CNB and minimizing complications like accidental dural puncture.

Moreover, pain management directly impacts the efficacy of spinal anesthesia. By ensuring that patients are relaxed and comfortable, it enhances the ability to administer the anesthetic precisely where needed, improving the likelihood of achieving the desired level of anesthesia and analgesia. Pain control also helps streamline the procedure by reducing delays associated with repositioning or adjusting the patient due to discomfort. This contributes to a more efficient process and shorter overall procedure time.

In addition to these technical benefits, effective pain management significantly improves the patient experience. Reducing pain and anxiety leads to a more positive experience, which can enhance patient cooperation and reduce overall stress during the procedure. Femoral nerve block is the most widely used standard peripheral block for ease of positioning in proximal femur fracture patients. However , recent advancements in multimodal pain management strategies, incorporating nerve blocks like ultrasound guided pericapsular nerve group block have demonstrated notable improvements in pain scores for ease of positioning in the femur fracture patients. Studies indicate that such strategies can reduce opioid consumption, improve pain scores, and decrease hospital stays. These advancements highlight the importance of preoperative pain management in optimizing recovery and enhancing surgical efficacy, ultimately underscoring its critical role in successful CNB and overall patient care.

There are many studies showing the effects of these two individual blocks for ease of positioning for central neuraxial blockade, but very few showing the comparisons between these blocks to conclude which block gives better pain control for ease of positioning.

For example, Kullenberg B.et al (2004),Francesca L.et al(2008),Purohit S. et al (2017),Acharya U.et al(2020),  Morrison C. et al(2021) are some of the studies showing the effect of femoral nerve block and pericapsular nerve group block on pain control individually for ease of positioning in hip fractures.  However, there are very less studies showing the comparison between these two blocks.

The primary objective of this study was to compare the Ultrasound-guided PENG block and the Ultrasound-guided FNB for ease of positioning for CNB in patients undergoing surgery for proximal femur fractures in terms of pain score(NRS), anaesthesiologist satisfaction score and patient’s satisfaction score.

To achieve these objectives, a randomized controlled trial (RCT) involving patients with proximal femur fractures is conducted from April 2025 to April 2026. Total of 52 Participants were randomly assigned to receive either the USG guided PENG block or USG guided FNB before positioning for CNB in groups of 26 each with injection Ropivacaine 0.2% 15 cc in each patient. Pain scores were assessed using Numerical rating score(NRS). Additionally, patient satisfaction and anaesthesiologist satisfaction were also assesed. The secondary objectives were to check for the total postoperative 24 hours analgesic requirement and quadriceps muscle power.


 
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