| CTRI Number |
CTRI/2026/04/107758 [Registered on: 07/04/2026] Trial Registered Prospectively |
| Last Modified On: |
03/04/2026 |
| Post Graduate Thesis |
No |
| Type of Trial |
Observational |
|
Type of Study
|
Cross Sectional Study |
| Study Design |
Other |
|
Public Title of Study
|
Relationship Between Neck Muscle Weakness and Reaction Time in People with Cervicogenic Headache |
|
Scientific Title of Study
|
Association between deep cervical flexor dysfunction and reaction time in patients with cervicogenic headache |
| Trial Acronym |
NIL |
|
Secondary IDs if Any
|
| Secondary ID |
Identifier |
| NIL |
NIL |
|
|
Details of Principal Investigator or overall Trial Coordinator (multi-center study)
|
| Name |
Mona Kumari |
| Designation |
BPT Student |
| Affiliation |
Institute of Physiotherapy and Rehabilitation, MMDU |
| Address |
Department of
Physiotherapy and Rehabilitation, Maharishi Markandeshwar
(Deemed to be University), Mullana Ambala, Haryana
Ambala
Ambala
HARYANA
133207
India |
| Phone |
7903962799 |
| Fax |
|
| Email |
m604chaudhary@gmail.com |
|
Details of Contact Person
Scientific Query
|
| Name |
Dr.Etika Rana |
| Designation |
Demonstrator |
| Affiliation |
Institute of Physiotherapy and Rehabilitation, MMDU |
| Address |
CABIN 4, ROOM NO .1 Department of Physiotherapy and Rehabilitation, Maharishi Markandeshwar
(Deemed to be University), Mullana Ambala, Haryana
Ambala
Physiotherapy and Rehabilitation, Maharishi Markandeshwar
Ambala
HARYANA
133207
India |
| Phone |
7018232435 |
| Fax |
|
| Email |
etikarana777@gmail.com |
|
Details of Contact Person
Public Query
|
| Name |
Mona Kumari |
| Designation |
BPT Student |
| Affiliation |
Institute of Physiotherapy and Rehabilitation, MMDU |
| Address |
Department of
Physiotherapy and Rehabilitation, Maharishi Markandeshwar
(Deemed to be University), Mullana Ambala, Haryana
Ambala
Ambala
HARYANA
133207
India |
| Phone |
7903962799 |
| Fax |
|
| Email |
m604chaudhary@gmail.com |
|
|
Source of Monetary or Material Support
|
| Maharishi Markandeshwar Institute of Medical
Sciences and Research, Maharishi Markandeshwar (deemed to be university), Mullana, Ambala,
Haryana 133207 |
|
|
Primary Sponsor
|
| Name |
Mona Kumari |
| Address |
Maharishi Markandeshwar Institute of Medical
Sciences and Research, Maharishi Markandeshwar (deemed to be university), Mullana, Ambala,
Haryana 133207 |
| Type of Sponsor |
Private medical college |
|
|
Details of Secondary Sponsor
|
|
|
Countries of Recruitment
|
India |
|
Sites of Study
|
| No of Sites = 1 |
| Name of Principal
Investigator |
Name of Site |
Site Address |
Phone/Fax/Email |
| Mona Kumari |
MMIPR,MULLANA, AMBALA ,HARYANA |
Room no. 1 Maharishi Markandeshwar Institute of Medical
Sciences and Research, Maharishi Markandeshwar (deemed to be university), Mullana, Ambala,
Haryana 133207
Ambala
HARYANA |
7903962799
m604chaudhary@gmail.com |
|
|
Details of Ethics Committee
|
| No of Ethics Committees= 1 |
| Name of Committee |
Approval Status |
| Institutional Ethical Committee, Maharishi Markandeshwar Institute of Medical Sciences and Research, Mullana, Ambala |
Approved |
|
|
Regulatory Clearance Status from DCGI
|
|
|
Health Condition / Problems Studied
|
| Health Type |
Condition |
| Patients |
(1) ICD-10 Condition: M629||Disorder of muscle, unspecified, |
|
|
Intervention / Comparator Agent
|
| Type |
Name |
Details |
| Intervention |
Assessment of Deep Cervical Flexor Function and Reaction Time |
Participants diagnosed with cervicogenic headache (18–30 years) will undergo assessment of deep cervical flexor muscle function using the Craniocervical Flexion Test with a pressure biofeedback unit. Visual reaction time will be assessed using a Simple Visual Reaction Time Test (Ruler Drop Test). No therapeutic intervention will be administered. This is an observational cross-sectional assessment study. |
|
|
Inclusion Criteria
|
| Age From |
18.00 Year(s) |
| Age To |
30.00 Year(s) |
| Gender |
Both |
| Details |
Adults aged 18–30 years. Clinically diagnosed with cervicogenic headache according to ICHD-3 criteria. Positive flexion-rotation test confirming upper cervical involvement. Ability to perform the craniocervical flexion test and ruler drop test. Both male and female participants. |
|
| ExclusionCriteria |
| Details |
Participants will be excluded if they have a history of traumatic brain injury or recent head/neck trauma within the past six months, neurological disorders affecting reaction time (such as stroke, Parkinson’s disease, or multiple sclerosis), previous cervical spine surgery, or migraine or tension-type headache as the primary diagnosis. Individuals with severe musculoskeletal conditions of the neck or upper limb (e.g., fractures or severe arthritis), visual or hearing impairments interfering with reaction time testing, and pregnant individuals will also be excluded to avoid confounding factors that may influence neuromuscular control and reaction time outcomes. |
|
|
Method of Generating Random Sequence
|
Not Applicable |
|
Method of Concealment
|
Not Applicable |
|
Blinding/Masking
|
Not Applicable |
|
Primary Outcome
|
| Outcome |
TimePoints |
| Association between deep cervical flexor muscle function assessed by the Craniocervical Flexion Test and simple visual reaction time measured using the ruler drop test in patients with cervicogenic headaches. |
Baseline (Single-session assessment) |
|
|
Secondary Outcome
|
| Outcome |
TimePoints |
Deep cervical flexor activation score (maximum pressure level achieved during the craniocervical flexion test),
Deep cervical flexor endurance (holding time in seconds during the craniocervical flexion test),
Mean simple visual reaction time (milliseconds) measured using the ruler drop test.
|
Baseline (single-session assessment). |
|
|
Target Sample Size
|
Total Sample Size="55"
Sample Size from India="55"
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" |
|
Phase of Trial
|
N/A |
|
Date of First Enrollment (India)
|
23/04/2026 |
| Date of Study Completion (India) |
Applicable only for Completed/Terminated trials |
| Date of First Enrollment (Global) |
23/04/2026 |
| Date of Study Completion (Global) |
Applicable only for Completed/Terminated trials |
|
Estimated Duration of Trial
|
Years="0"
Months="4"
Days="0" |
|
Recruitment Status of Trial (Global)
|
Not Yet Recruiting |
| Recruitment Status of Trial (India) |
Not Yet Recruiting |
|
Publication Details
|
N/A |
|
Individual Participant Data (IPD) Sharing Statement
|
Will individual participant data (IPD) be shared publicly (including data dictionaries)?
Response - NO
|
|
Brief Summary
|
Cervicogenic headache is a secondary headache arising from cervical spine dysfunction and is commonly associated with impaired deep cervical flexor muscle performance and altered neuromuscular control. Deep cervical flexor dysfunction may influence sensorimotor integration and response time; however, the relationship between deep cervical flexor dysfunction and reaction time in patients with cervicogenic headache has not been adequately explored. The present cross sectional observational study aims to evaluate the association between deep cervical flexor dysfunction and reaction time in patients diagnosed with cervicogenic headache. Deep cervical flexor function will be assessed using the craniocervical flexion test and endurance measurement. Reaction time will be measured using a standardized simple visual reaction time assessment. A total of fifty five participants will be recruited from physiotherapy outpatient services in India. Correlation analysis will be performed to determine the association between variables. The findings may provide insight into neuromuscular impairments associated with cervicogenic headache and assist in developing targeted rehabilitation strategies. |