| CTRI Number |
CTRI/2026/03/106321 [Registered on: 16/03/2026] Trial Registered Prospectively |
| Last Modified On: |
13/03/2026 |
| Post Graduate Thesis |
No |
| Type of Trial |
Interventional |
|
Type of Study
|
Yoga & Naturopathy |
| Study Design |
Randomized, Crossover Trial |
|
Public Title of Study
|
Measurement brain blood flow in response to 15 seconds of breath holding before and after anuloma viloma pranayama and quiet rest. |
|
Scientific Title of Study
|
Cerebrovascular responsivity in normal healthy persons following alternate nostril yoga breathing and quiet rest |
| Trial Acronym |
NIL |
|
Secondary IDs if Any
|
| Secondary ID |
Identifier |
| NIL |
NIL |
|
|
Details of Principal Investigator or overall Trial Coordinator (multi-center study)
|
| Name |
Dr Shirley Telles |
| Designation |
Consultant |
| Affiliation |
Patanjali Research Foundation (trust) |
| Address |
Department of Yoga Research, 2nd floor, Sadbhawana Building, Patanjali Research Foundation (Trust), Patanjali Yogpeeth Phase 1
Hardwar
UTTARANCHAL
249405
India |
| Phone |
09897963254 |
| Fax |
|
| Email |
office@prft.co.in |
|
Details of Contact Person
Scientific Query
|
| Name |
Dr Shirley Telles |
| Designation |
Consultant |
| Affiliation |
Patanjali Research Foundation (trust) |
| Address |
Department of Yoga Research, 2nd floor, Sadbhawana Building, Patanjali Research Foundation (Trust), Patanjali Yogpeeth Phase 1
Hardwar
UTTARANCHAL
249405
India |
| Phone |
09897963254 |
| Fax |
|
| Email |
office@prft.co.in |
|
Details of Contact Person
Public Query
|
| Name |
Dr Shirley Telles |
| Designation |
Consultant |
| Affiliation |
Patanjali Research Foundation (trust) |
| Address |
Department of Yoga Research, 2nd floor, Sadbhawana Building, Patanjali Research Foundation (Trust), Patanjali Yogpeeth Phase 1
Hardwar
UTTARANCHAL
249405
India |
| Phone |
09897963254 |
| Fax |
|
| Email |
office@prft.co.in |
|
|
Source of Monetary or Material Support
|
| Department of Yoga Research, 2nd floor, Sadbhawana Building, Patanjali Research |
|
|
Primary Sponsor
|
| Name |
Patanjali Research Foundation trust |
| Address |
Department of Yoga Research, 2nd floor, Sadbhawana Building, Patanjali Research Foundation (Trust), Patanjali Yogpeeth Phase 1 |
| Type of Sponsor |
Research institution |
|
|
Details of Secondary Sponsor
|
|
|
Countries of Recruitment
|
India |
|
Sites of Study
|
| No of Sites = 1 |
| Name of Principal
Investigator |
Name of Site |
Site Address |
Phone/Fax/Email |
| Dr Shirley Telles |
Patanjali Research Foundation (Trust) |
Department of Yoga Research, 2nd floor, Sadbhawana Building, Patanjali Research Foundation (Trust), Patanjali Yogpeeth Phase 1
Hardwar
UTTARANCHAL |
09897963254
office@prft.co.in |
|
|
Details of Ethics Committee
|
| No of Ethics Committees= 1 |
| Name of Committee |
Approval Status |
| Patanjali Research Foundation Trust |
Approved |
|
|
Regulatory Clearance Status from DCGI
|
|
|
Health Condition / Problems Studied
|
| Health Type |
Condition |
| Healthy Human Volunteers |
Based on semi structure Interview |
|
|
Intervention / Comparator Agent
|
| Type |
Name |
Details |
| Intervention |
Alternate nostril yoga breathing |
(i) Pre (2 minutes), (ii) During (5 minutes), and (iii) Post (2 minutes) |
| Comparator Agent |
Quiet rest (QR) |
(i) Pre (2 minutes), (ii) During (5 minutes), and (iii) Post (2 minutes) |
|
|
Inclusion Criteria
|
| Age From |
18.00 Year(s) |
| Age To |
35.00 Year(s) |
| Gender |
Both |
| Details |
Participants with (i) normal health based on a semi structured interview, and (ii) Students having at least 3 months of experience in breathing techniques (pranayama) |
|
| ExclusionCriteria |
| Details |
Those who will be taking medication and having history of smoking, consuming tobacco, alcohol, mental health disorders, extra systole, hypertension, respiratory conditions, disorders of hearing (based on self report and auditory threshold check) and cardiac conditions will be excluded from the study |
|
|
Method of Generating Random Sequence
|
Computer generated randomization |
|
Method of Concealment
|
Centralized |
|
Blinding/Masking
|
Participant Blinded |
|
Primary Outcome
|
| Outcome |
TimePoints |
1. Assessments of CVR (Cerebral blood flow velocity using TCD during 15 seconds of internal breath hold) before and after BBYB and HFYB
2. Only post the Nijmegen Questionnaire immediately after CVR
3. Respiration rate Pre 2 minutes, during 5 minutes, and post 2 minutes. |
1. Assessments of CVR (Cerebral blood flow velocity using TCD during 15 seconds of internal breath hold) before and after BBYB and HFYB
2. Only post the Nijmegen Questionnaire immediately after CVR
3. Respiration rate Pre 2 minutes, during 5 minutes, and post 2 minutes.
|
|
|
Secondary Outcome
|
| Outcome |
TimePoints |
| NIL |
NIL |
|
|
Target Sample Size
|
Total Sample Size="50"
Sample Size from India="50"
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" |
|
Phase of Trial
|
N/A |
|
Date of First Enrollment (India)
|
10/05/2026 |
| Date of Study Completion (India) |
Applicable only for Completed/Terminated trials |
| Date of First Enrollment (Global) |
Date Missing |
| Date of Study Completion (Global) |
Applicable only for Completed/Terminated trials |
|
Estimated Duration of Trial
|
Years="0"
Months="9"
Days="0" |
|
Recruitment Status of Trial (Global)
|
Not Applicable |
| Recruitment Status of Trial (India) |
Not Yet Recruiting |
|
Publication Details
|
N/A |
|
Individual Participant Data (IPD) Sharing Statement
|
Will individual participant data (IPD) be shared publicly (including data dictionaries)?
Response - NO
|
|
Brief Summary
|
The objective of the study is to determine the effect of alternate nostril yoga breathing on blood flow to the brain during 15 seconds of breath holding in healthy individuals. |