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CTRI Number  CTRI/2026/02/104742 [Registered on: 25/02/2026] Trial Registered Prospectively
Last Modified On: 02/06/2026
Post Graduate Thesis  No 
Type of Trial  Observational 
Type of Study   Ambispective study 
Study Design  Single Arm Study 
Public Title of Study   Study of treatment outcomes and relapse patterns in patients with Ewing’s sarcoma involving the brain or spinal cord coverings. 
Scientific Title of Study   Ewing’sSarcoma with Intradural Involvement: An Ambispective Study 
Trial Acronym  NIL 
Secondary IDs if Any  
Secondary ID  Identifier 
NIL  NIL 
 
Details of Principal Investigator or overall Trial Coordinator (multi-center study)  
Name  Dr Jifmi Jose Manjali 
Designation  Associate Professor, Radiation Oncology 
Affiliation  Tata Memorial Hospital 
Address  Department of Radiation Oncology, Main Building ground floor opd 93 Tata Memorial Hospital, Parel, Mumbai 400 012

Mumbai
MAHARASHTRA
400012
India 
Phone  7045714838  
Fax    
Email  jifmijosemanjali@gmail.com  
 
Details of Contact Person
Scientific Query
 
Name  Dr Jifmi Jose Manjali 
Designation  Associate Professor, Radiation Oncology 
Affiliation  Tata Memorial Hospital 
Address  Department of Radiation Oncology, Main Building ground floor opd 93 Tata Memorial Hospital, Parel, Mumbai 400 012

Mumbai
MAHARASHTRA
400012
India 
Phone  7045714838  
Fax    
Email  jifmijosemanjali@gmail.com  
 
Details of Contact Person
Public Query
 
Name  Dr Jifmi Jose Manjali 
Designation  Associate Professor, Radiation Oncology 
Affiliation  Tata Memorial Hospital 
Address  Department of Radiation Oncology, Main Building ground floor opd 93 Tata Memorial Hospital, Parel, Mumbai 400 012

Mumbai
MAHARASHTRA
400012
India 
Phone  7045714838  
Fax    
Email  jifmijosemanjali@gmail.com  
 
Source of Monetary or Material Support  
TATA MEMORIAL HOSPITAL, DR.E BORGES ROAD, PAREL MUMBAI - 400012 
 
Primary Sponsor  
Name  TATA MEMORIAL HOSPITAL  
Address  Dr.E.Ernst Borges Road, Mumbai 400012  
Type of Sponsor  Research institution and hospital 
 
Details of Secondary Sponsor  
Name  Address 
NIL  NIL 
 
Countries of Recruitment     India  
Sites of Study  
No of Sites = 1  
Name of Principal Investigator  Name of Site  Site Address  Phone/Fax/Email 
Dr Jifmi Jose Manjali  Tata Memorial Hospital   OPD 93, ground floor, Main Building Tata Memorial Hospital Dr.Ernst Borges Road, Mumbai
Mumbai
MAHARASHTRA 
7045714838

jifmijosemanjali@gmail.com 
 
Details of Ethics Committee  
No of Ethics Committees= 1  
Name of Committee  Approval Status 
Institutional Ethics Committee I Tata Memorial Hospital Mumbai  Approved 
 
Regulatory Clearance Status from DCGI  
Status 
Not Applicable 
 
Health Condition / Problems Studied  
Health Type  Condition 
Patients  (1) ICD-10 Condition: C419||Malignant neoplasm of bone and articular cartilage, unspecified,  
 
Intervention / Comparator Agent  
Type  Name  Details 
Intervention  Nil  Nil 
 
Inclusion Criteria  
Age From  1.00 Year(s)
Age To  99.00 Year(s)
Gender  Both 
Details  1.Patients diagnosed with histologically proven Ewing’s sarcoma of the dura, and vertebral/paravertebral/Chest wall/calvarial/skull base with intradural extension
2.Treated with radical intent at TMH/ACTREC from January 2013 to December 2030 (Partly treated in TMH/ACTREC or treatment advised from here)
3.Any age
4.With at least 6 months of follow-up
 
 
ExclusionCriteria 
Details  1.Patients treated with palliative intent
2.Less than 6 months of follow-up
3.Referred outside or defaulted for treatment
 
 
Method of Generating Random Sequence   Not Applicable 
Method of Concealment   Not Applicable 
Blinding/Masking   Not Applicable 
Primary Outcome  
Outcome  TimePoints 
To assess patterns of failure in patients with meningeal Ewing’s sarcoma either and patients with ewings sarcoma secondarily involvings the meninges.  after completion of treatment during follow-up every 3 months for first 2 to3 years, every 6 months for next 2 years, and annually thereafter up to 5 years. 
 
Secondary Outcome  
Outcome  TimePoints 
1.To assess outcomes [Local control (LC), Local Relapse Free Survival (LRFS), Disease Free Survival (DFS), Overall Survival (OS) in patients with meningeal sarcoma
2.To assess the relevance of systemic staging using FDG PET CECT
3.To assess prognostic factors for relapse
4.To compare LC, LRFS, DFS, OS & patterns of failure with vertebral/paravertebral/chestwall/calvarial/skull baseEwing’s sarcoma with intradural extension (secondary involvement)
 
At baseline,after completion of treatment; during follow-up every 3 months for first 2to3 years, every 6 months for next 2 years & annually thereafter up to 5 years. 
 
Target Sample Size
Modification(s)  
Total Sample Size="680"
Sample Size from India="680" 
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" 
Phase of Trial   N/A 
Date of First Enrollment (India)   09/03/2026 
Date of Study Completion (India) Applicable only for Completed/Terminated trials 
Date of First Enrollment (Global)  Date Missing 
Date of Study Completion (Global) Applicable only for Completed/Terminated trials 
Estimated Duration of Trial   Years="5"
Months="0"
Days="0" 
Recruitment Status of Trial (Global)   Not Applicable 
Recruitment Status of Trial (India)  Not Yet Recruiting 
Publication Details   N/A 
Individual Participant Data (IPD) Sharing Statement

Will individual participant data (IPD) be shared publicly (including data dictionaries)?  

Response - NO
Brief Summary  

Ewing’s sarcoma is a bone and soft tissue tumour commonly seen in children and young adults. Ewing’s sarcoma is primarily treated with a combination of chemotherapy and local therapy, which includes surgery and/or radiation therapy. About 20% of these tumours arise in extra-osseous sites, out of which 1-2% of tumours are dural-based lesions.Unlike peripheral PNETs, meningeal Ewing’s sarcomas are locally invasive and have a higher propensity for haematogenous spread to lungs and bone marrow. Among Ewing’s sarcoma, there is a possibility that meningeal Ewing’s sarcoma may behave differently as compared to other extraosseous sites. The recurrence rate in these cases ranges from 40-60%, distant craniospinal axis failure was reported in 41.2%, and two-year survival rates in the range of 30-60%.Owing to the rarity of meningeal Ewing’s sarcomas, the management protocol of these tumours is non-uniform, with few reports of craniospinal radiotherapy at presentation. There is a lack of definite uniform data on its patterns of relapse, outcomes, and underlying demographic characteristics. This ambispective study aims to contribute to the existing literature on meningeal Ewing’s sarcoma by understanding the clinical demographics, patterns of failure, outcomes and prognostic factors; thereby improving clinical decisions and facilitating improved treatment approaches.

 
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