| CTRI Number |
CTRI/2026/04/107269 [Registered on: 01/04/2026] Trial Registered Prospectively |
| Last Modified On: |
08/07/2026 |
| Post Graduate Thesis |
Yes |
| Type of Trial |
Observational |
|
Type of Study
|
Analytical Observational Study |
| Study Design |
Other |
|
Public Title of Study
|
A study of inflammation markers in two common skin conditions: Vicharchika and Dadru |
|
Scientific Title of Study
|
AN ANALYTICAL STUDY TO IDENTIFY THE INFLAMMATORY BIOMARKER PATTERNS IN VICHARCHIKA AND DADRU |
| Trial Acronym |
NIL |
|
Secondary IDs if Any
|
| Secondary ID |
Identifier |
| NIL |
NIL |
|
|
Details of Principal Investigator or overall Trial Coordinator (multi-center study)
|
| Name |
Dr Riya Tarunkumar Vashani |
| Designation |
Post Graduate Scholar |
| Affiliation |
Parul Institute of Ayurved and Research, Vadodara, Gujarat |
| Address |
Department of Roga Nidana Avum Vikriti Vigyan, Parul Institute of Ayurved and Research Parul University At Ishwarpura Post Limda Tal Waghodia Dist Vadodara, Gujarat, India 391760
Vadodara
GUJARAT
391760
India |
| Phone |
8733031187 |
| Fax |
|
| Email |
riyavashani1708@gmail.com |
|
Details of Contact Person
Scientific Query
|
| Name |
Dr Prashant Patil |
| Designation |
Associate Professor |
| Affiliation |
Parul Institute of Ayurved and Research, Vadodara, Gujarat |
| Address |
Department of Roga Nidana Evum Vikriti Vigyan, Parul Institute of Ayurved and Research Parul University At Ishwarpura Post Limda Tal Waghodia Dist Vadodara Gujarat India 391760
Vadodara
GUJARAT
391760
India |
| Phone |
7972675677 |
| Fax |
|
| Email |
prashant.patil26642@paruluniversity.ac.in |
|
Details of Contact Person
Public Query
|
| Name |
Dr Prashant Patil |
| Designation |
Associate Professor |
| Affiliation |
Parul Institute of Ayurved and Research, Vadodara, Gujarat |
| Address |
Department of Roga Nidana Evum Vikriti Vigyan, Parul Institute of Ayurved and Research Parul University At Ishwarpura Post Limda Tal Waghodia Dist Vadodara Gujarat India 391760
Vadodara
GUJARAT
391760
India |
| Phone |
7972675677 |
| Fax |
|
| Email |
prashant.patil26642@paruluniversity.ac.in |
|
|
Source of Monetary or Material Support
|
| Parul Institute of Ayurved and Research, Vadodara, Gujarat, India, Pin 391760 |
|
|
Primary Sponsor
|
| Name |
Dr Riya Tarunkumar Vashani |
| Address |
Post Graduate Scholar, Department of Roga Nidana Evum Vikriti Vigyan, Parul
Institute of Ayurved And Research, Vadodara, Gujarat, India, Pin- 391760 |
| Type of Sponsor |
Other [Self] |
|
|
Details of Secondary Sponsor
|
|
|
Countries of Recruitment
|
India |
|
Sites of Study
|
| No of Sites = 1 |
| Name of Principal
Investigator |
Name of Site |
Site Address |
Phone/Fax/Email |
| Dr Riya Vashani |
Khemdas Hospital |
OPD No. 9,Agadatantra Department, Khemdas Hospital, Parul University,
Ishwarpura, Vadodara, Gujarat
Vadodara
GUJARAT
Vadodara
GUJARAT |
08733031187
riyavashani1708@gmail.com |
|
|
Details of Ethics Committee
|
| No of Ethics Committees= 1 |
| Name of Committee |
Approval Status |
| INSTITUTIONAL ETHICAL COMMITTEE IEC-PIAR HR |
Approved |
|
|
Regulatory Clearance Status from DCGI
|
|
|
Health Condition / Problems Studied
|
| Health Type |
Condition |
| Patients |
(1) ICD-10 Condition:L245||Irritant contact dermatitis due toother chemical products. Ayurveda Condition: VICARCIKA, (2) ICD-10 Condition:L99||Other disorders of skin and subcutaneous tissue in diseases classified elsewhere. Ayurveda Condition: DADRU-KUSHTHAH, |
|
|
Intervention / Comparator Agent
|
| sno | Intervention/Comparator | Type | Drug-Type | Procedure Name | Details |
|
| Intervention |
Nil |
Nil |
| Intervention |
Nil |
Nil |
| Intervention |
Nil |
Nil |
|
|
Inclusion Criteria
|
| Age From |
18.00 Year(s) |
| Age To |
70.00 Year(s) |
| Gender |
Both |
| Details |
Diagnosed cases of Vicharchika and Dadru.
Age of patients in between 18 to 70 years irrespective of gender who are willing to give informed written consent.
|
|
| ExclusionCriteria |
| Details |
Immunocompromised Patients.
Participants on anti-inflammatory or immunomodulatory drugs.
|
|
|
Method of Generating Random Sequence
|
Not Applicable |
|
Method of Concealment
|
Not Applicable |
|
Blinding/Masking
|
Not Applicable |
|
Primary Outcome
|
| Outcome |
TimePoints |
Comparison of inflammatory biomarker levels (ESR, CRP, IL-6) between patients diagnosed with Vicharchika and Dadru.
Measurement will be done through laboratory blood investigations and values will be analysed to determine the pattern and variation of systemic inflammation between the two conditions. |
Baseline |
|
|
Secondary Outcome
|
| Outcome |
TimePoints |
Assessment of clinical features of Vicharchika and Dadru based on classical Ayurvedic symptoms such as Kandu, Pidaka, Shyava Varna, Srava, Raga, Mandala, etc., recorded during clinical examination.
Correlation between inflammatory biomarker levels and clinical presentation of Vicharchika and Dadru to understand the relationship between systemic inflammation and disease manifestation. |
Baseline |
|
|
Target Sample Size
|
Total Sample Size="40"
Sample Size from India="40"
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" |
|
Phase of Trial
|
N/A |
|
Date of First Enrollment (India)
|
15/04/2026 |
| Date of Study Completion (India) |
Applicable only for Completed/Terminated trials |
| Date of First Enrollment (Global) |
Date Missing |
| Date of Study Completion (Global) |
Applicable only for Completed/Terminated trials |
|
Estimated Duration of Trial
|
Years="1"
Months="6"
Days="0" |
|
Recruitment Status of Trial (Global)
|
Not Yet Recruiting |
| Recruitment Status of Trial (India) |
Not Yet Recruiting |
|
Publication Details
|
N/A |
|
Individual Participant Data (IPD) Sharing Statement
|
Will individual participant data (IPD) be shared publicly (including data dictionaries)?
Response - NO
|
Brief Summary
Modification(s)
|
Skin diseases are common inflammatory conditions that significantly affect quality of life. In Ayurveda, Vicharchika and Dadru are described under Kushtha Roga and present with symptoms such as itching, eruptions, discoloration, and erythema. Vicharchika is predominantly associated with Kapha-Pitta vitiation and clinically resembles eczema, whereas Dadru is mainly Pitta-Kapha predominant and correlates with fungal infections like tinea. Although these conditions share certain clinical features, their underlying pathogenesis differs according to Ayurvedic principles. Modern biomedical research recognizes inflammatory biomarkers such as Erythrocyte Sedimentation Rate (ESR), C-reactive Protein (CRP), Interleukin-6 (IL-6) and Immunoglobulin E as indicators of systemic inflammation in dermatological disorders. However, there is limited evidence correlating these biomarkers with specific Ayurvedic skin diseases or differentiating between conditions like Vicharchika and Dadru. The present analytical observational comparative study aims to evaluate and compare inflammatory biomarker patterns (ESR, CRP, IL-6 and IgE) in patients diagnosed with Vicharchika and Dadru. A total of 40 participants(20 Each group) fulfilling the diagnostic criteria will be recruited from the OPD/IPD of Khemdas Hospital using purposive sampling. Clinical features will be documented and blood investigations will be performed to estimate biomarker levels. The collected data will be statistically analysed to identify significant variations in inflammatory markers between the two groups. This study attempts to bridge Ayurvedic clinical concepts with modern inflammatory parameters and may contribute to improved diagnostic differentiation and evidence-based understanding of these dermatological conditions. |