CTRI

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CTRI Number

CTRI/2026/02/104783 [Registered on: 25/02/2026] Trial Registered Prospectively

Last Modified On:

25/02/2026

Post Graduate Thesis

Yes

Type of Trial

Interventional

Type of Study

Homeopathy

Study Design

Single Arm Study

Public Title of Study

Homeopathic Treatment for Anxiety, Stress and Depression in Older Adults 65 years and above: Does It Support Successful Aging?

Scientific Title of Study

Role of Homoeopathy in Promoting Resilient Aging in Geriatric Patients Positive on DASS 21 using Successful aging inventory (SAI): An Experimental Uncontrolled Study

Trial Acronym

NIL

Secondary IDs if Any

Secondary ID	Identifier
nil	Other

Details of Principal Investigator or overall Trial Coordinator (multi-center study)

Name	Dr Justina M Steefan
Designation	Associate Professor
Affiliation	Father Muller Homoeopathic Medical College and hospital
Address	Dr Justina M Steefan , Associate professor, department of psychiatry, Father Muller Homoeopathic Medical College and hospital, university road, Deralakatte, Karnataka Father Muller Homoeopathic Medical College and hospital, university road, Deralakatte, Karnataka Dakshina Kannada KARNATAKA 575018 India
Phone	8547964493
Fax
Email	drjustinasteefan@gmail.com

Details of Contact Person
Scientific Query

Name	Dr Sunita Nikumbh
Designation	Professor, Head of the department
Affiliation	MLDawale Memorial Homoeopathic Institute
Address	Dr Sunita Nikumbh PhD Guide and Head, Department of Psychiatry Room No 301 ML Dawale Memorial Homoeopathic Institute, Palghar ML Dawale Memorial Homoeopathic Institute, Palghar 401404 Palghar MAHARASHTRA 401404 India
Phone	7721076363
Fax
Email	sunita.nikumbh@gmail.com

Details of Contact Person
Public Query

Name	Dr Siddesha G
Designation	Associate Professor
Affiliation	Father Muller Homoeopathic Medical College and hospital
Address	Dr Siddesha G , Associate professor, department of psychiatry, Father Muller Homoeopathic Medical College and hospital, university road, Deralakatte, Karnataka Father Muller Homoeopathic Medical College and hospital, university road, Deralakatte, Karnataka Dakshina Kannada KARNATAKA 575018 India
Phone	8660861093
Fax
Email	drsiddesh009@gmail.com

Source of Monetary or Material Support

nil

Primary Sponsor

Name	Dr Justina M Steefan
Address	Father Muller Homoeopathic Medical College and hospital,University road, deralakatte
Type of Sponsor	Other [self]

Details of Secondary Sponsor

Name	Address
NIL	NIL

Countries of Recruitment

India

Sites of Study

No of Sites = 1
Name of Principal Investigator	Name of Site	Site Address	Phone/Fax/Email
Dr Sunita Nikumbh	ML Dawale Memorial Homoeopathic Institute, Palghar	Department of Psychiatry Room No 301 MLDawale Memorial Homoeopathic Institute, Palghar 401404 Palghar MAHARASHTRA	7721076363 sunita.nikumbh@gmail.com

Details of Ethics Committee

No of Ethics Committees= 1
Name of Committee	Approval Status
Institutional Ethics Committee, MLDMHI, Palghar	Approved

Regulatory Clearance Status from DCGI

Status

Not Applicable

Health Condition / Problems Studied

Health Type	Condition
Patients	(1) ICD-10 Condition: F330\|\|Major depressive disorder, recurrent, mild, (2) ICD-10 Condition: F419\|\|Anxiety disorder, unspecified,

Intervention / Comparator Agent

Type	Name	Details
Intervention	Individualized Homoeopathic Treatment	administration of homoeopathic remedies tailored specifically to the individuals symptoms and overall health condition.
Comparator Agent	Not applicable	Not applicable

Inclusion Criteria

Age From	65.00 Year(s)
Age To	90.00 Year(s)
Gender	Both
Details	Patients who are positive on DASS 21 scale (mild depression, mild anxiety and mild stress) Patients who have any systemic illness as comorbidity. (they will be continuing the medications for the same)

ExclusionCriteria

Details

Cognitive impairment – Patients who has score less than 24 in MMSE
Patients who are taking allopathic medications for any Psychiatric illness
Concurrent participation in other clinical trials involving interventions for anxiety, depression or stress
Those who are positive on DASS 21 but in moderate and severe categories of depression, anxiety and stress.

Method of Generating Random Sequence

Not Applicable

Method of Concealment

Not Applicable

Blinding/Masking

Not Applicable

Primary Outcome

Outcome	TimePoints
Change in total score of the Successful Aging Inventory (SAI) following individualized homoeopathic treatment	Screening and pre intervention assessments – 3 months Intervention and post intervention assessments – 12 months Data analysis and interpretation of the results – 3 months Total duration – 1 year 6 months

Secondary Outcome

Outcome	TimePoints
Change in domain-wise scores of the Successful Aging Inventory (SAI), including: Functional Performance Mechanisms Intrapsychic Factors Spirituality Gerotranscendence	Screening and pre intervention assessments – 3 months Intervention and post intervention assessments – 12 months
Change in Depression, Anxiety, and Stress levels as measured by the Depression Anxiety Stress Scales–21 (DASS-21)	Screening and pre intervention assessments – 3 months Intervention and post intervention assessments – 12 months

Target Sample Size

Total Sample Size="37"
Sample Size from India="37"
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials"

Phase of Trial

N/A

Date of First Enrollment (India)

01/04/2026

Date of Study Completion (India)

Applicable only for Completed/Terminated trials

Date of First Enrollment (Global)

Date Missing

Date of Study Completion (Global)

Applicable only for Completed/Terminated trials

Estimated Duration of Trial

Years="1"
Months="6"
Days="0"

Recruitment Status of Trial (Global)

Not Applicable

Recruitment Status of Trial (India)

Not Yet Recruiting

Publication Details

N/A

Individual Participant Data (IPD) Sharing Statement

Will individual participant data (IPD) be shared publicly (including data dictionaries)?

Response - NO

Brief Summary

This study aims to evaluate the effectiveness of individualized homoeopathic treatment in promoting healthy and resilient aging among geriatric patients aged 65 years and above who have elevated scores on the Depression Anxiety and Stress Scale 21. Psychological distress in the elderly is common and may negatively influence overall wellbeing functional ability and quality of life. A holistic intervention that addresses both psychological and adaptive dimensions of aging may support better health outcomes in this population.

The primary objective of the study is to assess changes in healthy aging as measured by the Successful Aging Inventory. Secondary objectives include evaluating the effect of individualized homoeopathic treatment on specific domains of successful aging such as functional performance mechanisms intrapsychic factors spirituality and gerotranscendence. The study will also assess changes in depression anxiety and stress levels using the DASS 21 scale.

This is an experimental uncontrolled study conducted in a homoeopathic medical college hospital and associated centers. Participants who meet the inclusion criteria will receive individualized homoeopathic treatment based on classical principles. Baseline assessments will be conducted using DASS 21 and the Successful Aging Inventory followed by periodic follow up assessments every three months for one year.

The findings of this study are expected to provide evidence regarding the role of individualized homoeopathy in enhancing psychological wellbeing and promoting resilient aging in the geriatric population.