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CTRI Number  CTRI/2026/02/104432 [Registered on: 20/02/2026] Trial Registered Prospectively
Last Modified On: 19/02/2026
Post Graduate Thesis  Yes 
Type of Trial  Interventional 
Type of Study   Drug
Ayurveda 
Study Design  Randomized, Parallel Group, Active Controlled Trial 
Public Title of Study   Comparing Ayurvedic Eye Drops and Eye Application in Conjunctivitis 
Scientific Title of Study   A RANDOMIZED COMPARATIVE CLINICAL STUDY TO EVALUATE THE EFFECT OF PASHUPATA VARTI ANJANA AND PASHUPATA EYE DROPS IN ABHISHYANDA W.S.R. TO CONJUNCTIVITIS. 
Trial Acronym  NIL 
Secondary IDs if Any  
Secondary ID  Identifier 
NIL  NIL 
 
Details of Principal Investigator or overall Trial Coordinator (multi-center study)  
Name  Dr Sumi S 
Designation  PG SCHOLAR 
Affiliation  Parul Institue of Ayurved and Research 
Address  Department of Shalakya Tantra Parul institute of ayurved and research Parul University. P.O.Limda, Tal.Waghodia - 391760 Dist.Vadodara, Gujarat

Vadodara
GUJARAT
391760
India 
Phone  6374725361  
Fax    
Email  drsumisinnapillai@gmail.com  
 
Details of Contact Person
Scientific Query  
Name  Dr Ganesh Tejasvi S 
Designation  Associate Professor 
Affiliation  Parul Institue of Ayurved and Research 
Address  Department of Shalakya Tantra Parul institute of ayurved and research Parul University. P.O.Limda, Tal.Waghodia - 391760 Dist.Vadodara, Gujarat

Vadodara
GUJARAT
391760
India 
Phone  9164774710  
Fax    
Email  ganeshtejasvi@gmail.com  
 
Details of Contact Person
Public Query  
Name  Dr Ganesh Tejasvi S 
Designation  Associate Professor 
Affiliation  Parul Institue of Ayurved and Research 
Address  Department of Shalakya Tantra Parul institute of ayurved and research Parul University. P.O.Limda, Tal.Waghodia - 391760 Dist.Vadodara, Gujarat

Vadodara
GUJARAT
391760
India 
Phone  9164774710  
Fax    
Email  ganeshtejasvi@gmail.com  
 
Source of Monetary or Material Support  
NIL 
 
Primary Sponsor  
Name  Dr Sumi S 
Address  Department of Shalakya tantra, Parul Institute of Ayurved and Research, Parul University, Ishwarpura road, Limda, Vadodara, Gujarat - 391760, India. 
Type of Sponsor  Other [SELF] 
 
Details of Secondary Sponsor  
Name  Address 
NIL  NIL 
 
Countries of Recruitment     India  
Sites of Study  
No of Sites = 1  
Name of Principal Investigator  Name of Site  Site Address  Phone/Fax/Email 
Dr Sumi S  KHEMDAS HOSPITAL  OPD no.4, Eye OPD, Department of Shalakya Tantra, Ground floor, Parul Institute of Ayurved and Research, Parul University, Vadodara - 391760, Gujarat, India. Vadodara GUJARAT
Vadodara
GUJARAT 		 6374725361

drsumisinnapillai@gmail.com 
 
Details of Ethics Committee  
No of Ethics Committees= 1  
Name of Committee  Approval Status 
PIAR-IECHR  Approved 
 
Regulatory Clearance Status from DCGI  
Status 
Not Applicable 
 
Health Condition / Problems Studied  
Health Type  Condition 
Patients  (1) ICD-10 Condition:H10||Conjunctivitis. Ayurveda Condition: ABISHYANDAH,  
 
Intervention / Comparator Agent  
snoIntervention/ComparatorTypeDrug-TypeProcedure NameDetails
1Comparator ArmProcedure-a~jjanam, अंजनम् (Procedure Reference: Sushruta Samhita, Uttara Tantra, Procedure details: Collyrium applying the inner canthus of eyes and washing it with clean water after 10 minutes)
(1) Medicine Name: Pashupata Varti, Reference: Ashtanga Hrudaya, Uttara Sthana, Chapter 16, sloka 25-27, Route: Topical, Dosage Form: Varti/ Suppository, Dose: 250(mg), Frequency: bd, Duration: 7 Days
2Intervention ArmDrugOther than Classical(1) Medicine Name: Pashupata Eye Drops, Reference: NA, Route: Topical, Dosage Form: Bindu/ Drops/ Spray (Karna/ Nasa/ Netra/ Mukha), Dose: 1(drops), Frequency: qid, Bhaishajya Kal: Muhurmuhu, Duration: 7 Days, anupAna/sahapAna: No, Additional Information: -
 
Inclusion Criteria  
Age From  18.00 Year(s)
Age To  60.00 Year(s)
Gender  Both 
Details  1. Participants between the age group of 18-60 years will be selected irrespective of gender.
2. Participants fulfilling one or more features of conjunctivitis.  
 
ExclusionCriteria 
Details  1. Participants with keratoconjunctivitis, giant papillary conjunctivitis.
2. Known case of glaucoma.
3. Participants who have undergone eye surgery within last 6 months and suffering from corneal pathology, ocular injuries and suspected foreign body in the eye.
4. Participants taking anti allergic medication and also using any kind of eye drops.
5. Pregnant ladies and lactating mothers. 
 
Method of Generating Random Sequence   Computer generated randomization 
Method of Concealment   Case Record Numbers 
Blinding/Masking   Not Applicable 
Primary Outcome  
Outcome  TimePoints 
Reduction in the signs and symptoms of conjunctivitis assessed using a clinical grading score.  Baseline, 7th day and 14th day 
 
Secondary Outcome  
Outcome  TimePoints 
Evaluation and comparison of the efficacy of Pashupata Varti Anjana and Pashupata Eye Drops.  on 7th day and 14th day 
 
Target Sample Size   Total Sample Size="100"
Sample Size from India="100" 
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" 
Phase of Trial   Phase 2 
Date of First Enrollment (India)   08/07/2026 
Date of Study Completion (India) Applicable only for Completed/Terminated trials 
Date of First Enrollment (Global)  Date Missing 
Date of Study Completion (Global) Applicable only for Completed/Terminated trials 
Estimated Duration of Trial   Years="1"
Months="6"
Days="0" 
Recruitment Status of Trial (Global)   Not Yet Recruiting 
Recruitment Status of Trial (India)  Not Yet Recruiting 
Publication Details   N/A 
Individual Participant Data (IPD) Sharing Statement

Will individual participant data (IPD) be shared publicly (including data dictionaries)?  

Response - YES
  1. What data in particular will be shared?
    Response - All of the individual participant data collected during the trial, after de-identification.

  2. What additional supporting information will be shared?
    Response -  Study Protocol
    Response -  Statistical Analysis Plan
    Response - Informed Consent Form
    Response - Clinical Study Report

  3. Who will be able to view these files?
    Response - Researchers whose proposed use of the data has been approved by an independent review committee identified for this purpose.

  4. For what types of analyses will this data be available?
    Response - To achieve aims in the approved proposal.

  5. By what mechanism will data be made available?
    Response - Proposals should be directed to [drsumisinnapillai@gmail.com].

  6. For how long will this data be available start date provided 22-07-2027 and end date provided 21-07-2028?
    Response (Others) -  oone year post publication of research paper

  7. Any URL or additional information regarding plan/policy for sharing IPD? 
    Additional Information - NIL
Brief Summary  
This randomized comparative clinical trial is designed to evaluate and compare the safety and therapeutic efficacy of Pashupata Varti Anjana and Pashupata Eye Drops in the management of Abhishyanda, which is correlated with conjunctivitis in modern medicine. Abhishyanda is characterized by symptoms such as redness, itching, discharge, burning sensation, and irritation of the eyes. A total of 100 participants diagnosed with Abhishyanda will be randomly allocated into two groups. One group will receive Pashupata Varti Anjana, while the other group will receive Pashupata Eye Drops for a duration of 7 days. Clinical assessment will be done based on subjective symptoms and objective ophthalmological findings before and after treatment. The objective of the study is to scientifically evaluate and compare the effectiveness, safety, and patient acceptability of the traditional Anjana form and the modified eye drop form of Pashupata formulation. The study aims to provide clinical evidence for the use of Ayurvedic formulations as a safe and effective treatment option for conjunctivitis.
 
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