| CTRI Number |
CTRI/2026/02/103980 [Registered on: 16/02/2026] Trial Registered Prospectively |
| Last Modified On: |
14/02/2026 |
| Post Graduate Thesis |
Yes |
| Type of Trial |
Interventional |
|
Type of Study
|
Ayurveda |
| Study Design |
Randomized, Parallel Group Trial |
|
Public Title of Study
|
A Clinical Study On Effect Of Pippalyadi choorna and Talisadi choorna in the management of Kaphaja Kasa. |
|
Scientific Title of Study
|
Randomized Controlled Clinical Trial To Study The Efficacy of Pippalyadi Choorna and Talisadi Choorna In The Management of Kaphaja Kasa With Special Reference to Allergic Bronchitis. |
| Trial Acronym |
Nil |
|
Secondary IDs if Any
|
| Secondary ID |
Identifier |
| Nil |
NIL |
|
|
Details of Principal Investigator or overall Trial Coordinator (multi-center study)
|
| Name |
Dr Shreya Kamalakar Dikkatwar |
| Designation |
MD Scholar Kayachikitsa (Ayurveda) |
| Affiliation |
LRP Ayurvedic college Hospital PG Institute And Research Centre |
| Address |
OPD No 1,Department of Kayachikitsa, LRP Ayurvedic Medical College Hospital PG Institute And Research Centre Urun Islampur, Sangli
OPD No 1, Department of Kayachikitsa,LRP Ayurvedic Medical College Hospital PG Institute And Research Centre Urun Islampur, Sangli
Sangli
MAHARASHTRA
415409
India |
| Phone |
7385772271 |
| Fax |
|
| Email |
shreya.dikkatwar@gmail.com |
|
Details of Contact Person
Scientific Query
|
| Name |
Dr Abhinandan Patil |
| Designation |
HOD Professor And Guide |
| Affiliation |
LRP Ayurvedic college Hospital PG Institute And Research Centre |
| Address |
OPD No 1 Department of Kayachikitsa,LRP Ayurvedic Medical College Hospital PG Institute And Research Centre Urun Islampur, Sangli
OPD No 1 Department of Kayachikitsa,LRP Ayurvedic Medical College Hospital PG Institute And Research Centre Urun Islampur, Sangli
Sangli
MAHARASHTRA
415409
India |
| Phone |
9890205000 |
| Fax |
|
| Email |
drabhinandanpatil@gmail.com |
|
Details of Contact Person
Public Query
|
| Name |
Dr Abhinandan Patil |
| Designation |
HOD Professor And Guide |
| Affiliation |
LRP Ayurvedic college Hospital PG Institute And Research Centre |
| Address |
OPD No 1 Department of Kayachikitsa,LRP Ayurvedic Medical College Hospital PG Institute And Research Centre Urun Islampur, Sangli
OPD No 1 Department of Kayachikitsa LRP Ayurvedic Medical College Hospital PG Institute And Research Centre Urun Islampur, Sangli
Sangli
MAHARASHTRA
415409
India |
| Phone |
9890205000 |
| Fax |
|
| Email |
drabhinandanpatil@gmail.com |
|
|
Source of Monetary or Material Support
|
| LRP Ayurvedic Medical College And Hospital PG institute and Research Centre Urun Islampur Taluka Walwa District Sangli Maharashtra India Pin code 415409 |
|
|
Primary Sponsor
|
| Name |
Dr Shreya Kamalakar Dikkatwar |
| Address |
LRP Ayurvedic Medical College And Hospital PG institute and Research Centre Urun Islampur Sangali Maharashtra India Pin code 415409 |
| Type of Sponsor |
Other [Self] |
|
|
Details of Secondary Sponsor
|
|
|
Countries of Recruitment
|
India |
|
Sites of Study
|
| No of Sites = 1 |
| Name of Principal
Investigator |
Name of Site |
Site Address |
Phone/Fax/Email |
| Dr Shreya Kamalakar Dikkatwar |
LRP Ayurvedic Medical College And Hospital PG institute and Research Centre |
OPD No 1 Department of Kayachikitsa LRP Ayurvedic Medical College And Hospital PG institute and Research Centre Urun Islampur Sangali Pin Code 415409
Sangli
MAHARASHTRA |
7385772271
shreya.dikkatwar@gmail.com |
|
|
Details of Ethics Committee
|
| No of Ethics Committees= 1 |
| Name of Committee |
Approval Status |
| Institution Ethics Committee |
Approved |
|
|
Regulatory Clearance Status from DCGI
|
|
|
Health Condition / Problems Studied
|
| Health Type |
Condition |
| Patients |
(1) ICD-10 Condition:J069||Acute upper respiratory infection,unspecified. Ayurveda Condition: KASAH, |
|
|
Intervention / Comparator Agent
|
| sno | Intervention/Comparator | Type | Drug-Type | Procedure Name | Details | | 1 | Intervention Arm | Drug | Classical | | (1) Medicine Name: Pippalyadi Choorna, Reference: Gadanighra Kayachikitsa Khand Kasadhikar Prakaranam Chpt 10 Shloka 67, Route: Oral, Dosage Form: Churna/ Powder, Dose: 4(g), Frequency: tds, Bhaishajya Kal: Adhobhakta, Duration: 14 Days, anupAna/sahapAna: Yes(details: -Madhu), Additional Information: - | | 2 | Comparator Arm | Drug | Classical | | (1) Medicine Name: Talisadi Choorna, Reference: Bhaishajya Ratnavali Rajyakshma Rogadhikara chpt 14 shloka 29 to 33, Route: Oral, Dosage Form: Churna/ Powder, Dose: 4(g), Frequency: tds, Bhaishajya Kal: Adhobhakta, Duration: 14 Days, anupAna/sahapAna: Yes(details: -Madhu), Additional Information: - |
|
|
|
Inclusion Criteria
|
| Age From |
18.00 Year(s) |
| Age To |
60.00 Year(s) |
| Gender |
Both |
| Details |
1.Patient with sign and symptoms of Kaphaja Kasa.
2.Patient age group between 18 to 60 yrs.
3.Patients selected irrespective of age, Sex, socio economic status.
4.Patients who are willing to give consent for this study. |
|
| ExclusionCriteria |
| Details |
1.Pregnancy and Lactating Mother.
2.History of Allergy to Medicine
3.Patient with other co-morbidities like Diabetes Mellitus, HIV, Tuberculosis, pleural effusion, Cor Pulmonale Pneumonia etc.
4.Whooping cough, Tonsillitis.
5.Not willing to give consent.
6.Patients on steroid therapy and chemo therapy
7.Patients with age of below 18 years and above 60 years will be excluded. |
|
|
Method of Generating Random Sequence
|
Not Applicable |
|
Method of Concealment
|
Not Applicable |
|
Blinding/Masking
|
Not Applicable |
|
Primary Outcome
|
| Outcome |
TimePoints |
| To study the efficacy of Pippalyadi choorna in the management of Kaphaja Kasa with special reference to Allergic Bronchitis |
0 baseline, 7 days, 14 days
21 days |
|
|
Secondary Outcome
|
| Outcome |
TimePoints |
1.To study the Kaphaja Kasa in detail.
2.To study the Allergic Bronchitis in detail.
3.To study in detail about Pipplayadi Choorna & Talisadi Choorna.
4.To study the mode of action of Pippalyadi choorna in Kaphaja Kasa
5.To study the mode of action of Talisadi choorna in kaphaja kasa |
0 baseline
7 days
14 days
21 days |
|
|
Target Sample Size
|
Total Sample Size="70"
Sample Size from India="70"
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" |
|
Phase of Trial
|
Phase 2/ Phase 3 |
|
Date of First Enrollment (India)
|
01/08/2026 |
| Date of Study Completion (India) |
Applicable only for Completed/Terminated trials |
| Date of First Enrollment (Global) |
Date Missing |
| Date of Study Completion (Global) |
Applicable only for Completed/Terminated trials |
|
Estimated Duration of Trial
|
Years="1"
Months="6"
Days="0" |
|
Recruitment Status of Trial (Global)
|
Not Yet Recruiting |
| Recruitment Status of Trial (India) |
Not Yet Recruiting |
|
Publication Details
|
N/A |
|
Individual Participant Data (IPD) Sharing Statement
|
Will individual participant data (IPD) be shared publicly (including data dictionaries)?
Response - NO
|
|
Brief Summary
|
Kayachikitsa is a crucially important clinical subject because of its unique approach towards treatments, principles and their descriptions, medicinal problem which affects people’s health and there is a separate section in all Samhitas. The main aim of ayurveda is to maintain health state and cure the sickness of the body. Today’s environment exposes us several toxins by pollution, overpopulation, chemicals, infectious organisms in ambient air and the human respiratory tract exposed to such environment causes cough as major symptom, which is described as Kasa in ayurveda and is also independent disease. Forceful expulsion of Vayu from throat is called as Kasa. There are five types of Kasa namely Vataj, Pittaj, Kaphaja, kshataj, kshayaj among which Kaphaja Kasa is one of the common diseases affecting the community. The essential disposition of living activity is said to be breathing which is a basic activity of pranvaha srotas. Kaphaja Kasa is a disease of pranavaha srotas that is one of the types of Kasa. According to ayurveda, Kasa is an independent disease as well as symptom. It has separate pathogenesis, sign, symptoms, types, and treatment of Kaphaja Kasa and it having the following symptoms Kasa, sthivan, utklesh, shwaskshtata agnimandya and peenas. Among these various Yogas, choorna is the easiest form to take, which is also cost effective, hence Pippalyadi choorna were selected for this study for the management of Kaphaja Kasa
Need Of Study Now a days available conventional management for Kaphaja Kasa in Ayurvedic treatment is the best among them. Although lot of work has been done on Kaphaja Kasa still the disease challenges our medical sciences so it requires further research and proper treatment by ayurvedic medicine. Ayurveda considers various factors like dosha imbalance, lifestyle, diet, and environmental influences. Studying Kaphaja Kasa in this context provides a comprehensive and personalized approach to treatment. Pippalyadi choorna has contents which can do Sampraptibhanga of Kaphaja Kasa and can give relief to the patients. Taking all these points in to consideration the study is planned to evaluate the effect of Pippalyadi choorna in Kaphaja Kasa. |