| CTRI Number |
CTRI/2026/02/104321 [Registered on: 19/02/2026] Trial Registered Prospectively |
| Last Modified On: |
18/02/2026 |
| Post Graduate Thesis |
Yes |
| Type of Trial |
Interventional |
|
Type of Study
|
Physiotherapy (Not Including YOGA) |
| Study Design |
Randomized, Parallel Group Trial |
|
Public Title of Study
|
Study to evaluate the effect of repetitive transcranial magnetic stimulation on walking ability in patients with parkinson disease |
|
Scientific Title of Study
|
Effects of repetitive transcranial magnetic stimulation on temporal and spatial parameters of gait in individuals with parkinson disease |
| Trial Acronym |
|
|
Secondary IDs if Any
|
| Secondary ID |
Identifier |
| NIL |
NIL |
|
|
Details of Principal Investigator or overall Trial Coordinator (multi-center study)
|
| Name |
Dr Narkeesh Arumugam |
| Designation |
Professor |
| Affiliation |
Physiotherapy Department Punjabi University Patiala |
| Address |
Physiotherapy Department
Punjabi University
Patiala
Punjab
147002
India
Patiala
PUNJAB
147002
India |
| Phone |
9417802662 |
| Fax |
|
| Email |
narkeesh@gmail.com |
|
Details of Contact Person
Scientific Query
|
| Name |
Narkeesh Arumugam |
| Designation |
Professor |
| Affiliation |
Physiotherapy Department Punjabi University Patiala |
| Address |
Physiotherapy Department
Punjabi University
Patiala
Punjab
147002
India
Patiala
PUNJAB
147002
India |
| Phone |
9417802662 |
| Fax |
|
| Email |
narkeesh@gmail.com |
|
Details of Contact Person
Public Query
|
| Name |
AMANDEEP SINGH |
| Designation |
Postgraduate Student |
| Affiliation |
Physiotherapy Department Punjabi University Patiala |
| Address |
Physiotherapy Department
Punjabi University
Patiala
Punjab
147002
India
Patiala
PUNJAB
147002
India |
| Phone |
6283131429 |
| Fax |
|
| Email |
aman2100000@gmail.com |
|
|
Source of Monetary or Material Support
|
|
|
Primary Sponsor
|
| Name |
AMANDEEP SINGH |
| Address |
Physiotherapy Department
Punjabi University
Patiala
Punjab
147002
India |
| Type of Sponsor |
Other [self] |
|
|
Details of Secondary Sponsor
|
|
|
Countries of Recruitment
|
India |
|
Sites of Study
|
| No of Sites = 1 |
| Name of Principal
Investigator |
Name of Site |
Site Address |
Phone/Fax/Email |
| Dr Narkeesh Arumugam |
Bhai Ghaniya Health centre and Neuroots Neurorehabilitation Centre |
Physiotherapy Unit Neurological OPD-II Punjabi University Patiala Punjab
Neuroots Neurorehabilitation centre Patiala Punjab
Patiala
PUNJAB |
9417802662
Narkeesh@gmail.com |
|
|
Details of Ethics Committee
|
| No of Ethics Committees= 1 |
| Name of Committee |
Approval Status |
| Institutional Ethical Committee Punjabi University Patiala |
Approved |
|
|
Regulatory Clearance Status from DCGI
|
|
|
Health Condition / Problems Studied
|
| Health Type |
Condition |
| Patients |
(1) ICD-10 Condition: G328||Other specified degenerative disorders of nervous system in diseases classified elsewhere, |
|
|
Intervention / Comparator Agent
|
| Type |
Name |
Details |
| Intervention |
rTMS and conventional treatment |
10 Hz + intensity 80% of RMT + 1200 pulses for 10 minutes per session – 5 days/week for 3 weeks |
| Comparator Agent |
sham rTMS,conventional treatment |
Conventional Exercises will be instructed to the participants and performed by participants 5 days/week for 45 minutes for 3 weeks |
|
|
Inclusion Criteria
|
| Age From |
55.00 Year(s) |
| Age To |
85.00 Year(s) |
| Gender |
Both |
| Details |
Individuals who will be willing to Participate.
Confirmed Diagnosis of Parkinson Disease.
Ability to provide informed consent.
Individuals with hoehn and yahr stage between 2 and 4 |
|
| ExclusionCriteria |
| Details |
Individuals with any other
neurological Disorder
Non-cooperative individuals
Metallic implant near the stimulation site
Individuals with any musculoskeletal disorders that are affecting gait patterns
|
|
|
Method of Generating Random Sequence
|
Computer generated randomization |
|
Method of Concealment
|
An Open list of random numbers |
|
Blinding/Masking
|
Participant and Investigator Blinded |
|
Primary Outcome
|
| Outcome |
TimePoints |
| 2D gait Analysis |
At the baseline
10th day and
20th day |
|
|
Secondary Outcome
|
| Outcome |
TimePoints |
| MDS-UPDRS-III AND PDQ-39 |
At the baseline
10th day and
20th day |
|
|
Target Sample Size
|
Total Sample Size="20"
Sample Size from India="20"
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" |
|
Phase of Trial
|
N/A |
|
Date of First Enrollment (India)
|
16/03/2026 |
| Date of Study Completion (India) |
Applicable only for Completed/Terminated trials |
| Date of First Enrollment (Global) |
Date Missing |
| Date of Study Completion (Global) |
Applicable only for Completed/Terminated trials |
|
Estimated Duration of Trial
|
Years="0"
Months="6"
Days="0" |
|
Recruitment Status of Trial (Global)
|
Not Applicable |
| Recruitment Status of Trial (India) |
Not Yet Recruiting |
|
Publication Details
|
N/A |
|
Individual Participant Data (IPD) Sharing Statement
|
Will individual participant data (IPD) be shared publicly (including data dictionaries)?
Response - NO
|
|
Brief Summary
|
Parkinson’s Disease is a progressive neurodegenerative disorder that mainly affects individuals over 60 years and is more common in men. It is diagnosed clinically by features such as bradykinesia, rigidity, tremor, and postural instability. Conventional physiotherapy focuses on improving gait, balance, posture, and functional mobility. Repetitive transcranial magnetic stimulation rTMS has emerged as an adjunct therapy, showing benefits in gait, freezing of gait, and motor performance. Treatment outcomes are commonly assessed using UPDRS, PDQ-39, and 2D gait analysis to evaluate motor and functional status. |