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CTRI Number  CTRI/2026/02/103677 [Registered on: 12/02/2026] Trial Registered Prospectively
Last Modified On: 11/02/2026
Post Graduate Thesis  No 
Type of Trial  Observational 
Type of Study   Cross Sectional Study 
Study Design  Single Arm Study 
Public Title of Study   Fitness Levels and Their Link to Memory, Attention, and Brain Health 
Scientific Title of Study   A triangulation study among cardio pulmonary fitness executive functions and selected neurochemical variables of young adults 
Trial Acronym  NIL 
Secondary IDs if Any  
Secondary ID  Identifier 
NIL  NIL 
 
Details of Principal Investigator or overall Trial Coordinator (multi-center study)  
Name  Prosanta Paul 
Designation  PhD Research Scholar 
Affiliation  Jadavpur University 
Address  Department of Physical Education , Jadavpur University, Kolkata 700032

Kolkata
WEST BENGAL
700032
India 
Phone  9093619974  
Fax    
Email  prosantap.phed.rs@jadavpuruniversity.in  
 
Details of Contact Person
Scientific Query  
Name  Dr. Sridip Chatterjee 
Designation  Associate Professor 
Affiliation  Jadavpur University 
Address  Department of Physical Education , Jadavpur University, Kolkata 700032, West Bengal, India

Kolkata
WEST BENGAL
700032
India 
Phone  9093619974  
Fax    
Email  sridipchatterjee.ped@jadavpuruniversity.in  
 
Details of Contact Person
Public Query  
Name  Prosanta Paul 
Designation  PhD Research Scholar 
Affiliation  Jadavpur University 
Address  Department of Physical Education , Jadavpur University, Kolkata 700032

Kolkata
WEST BENGAL
700032
India 
Phone  9093619974  
Fax    
Email  prosantap.phed.rs@jadavpuruniversity.in  
 
Source of Monetary or Material Support  
Exercise and sports physiology laboratory, Department of Physical Education, Jadavpur University, Kolkata 700032, West Bengal, India 
 
Primary Sponsor  
Name  Exercise and sports physiology laboratory Department of Physical Eduaction Jadavpur University 
Address  Department of Physical Education, Jadavpur University, Kolkata 700032, West Bengal, India 
Type of Sponsor  Other [State Government University] 
 
Details of Secondary Sponsor  
Name  Address 
NIL  NIL 
 
Countries of Recruitment     India  
Sites of Study  
No of Sites = 1  
Name of Principal Investigator  Name of Site  Site Address  Phone/Fax/Email 
Prosanta Paul  Jadavpur University  Exercise and sports physiology laboratory, Department of Physical Education, Jadavpur University, Kolkata 700032, West Bengal, India
Kolkata
WEST BENGAL 		 9093619974

prosantap.phed.rs@jadavpuruniversity.in 
 
Details of Ethics Committee  
No of Ethics Committees= 1  
Name of Committee  Approval Status 
Jadavpur University Institutional Ethics Committee  Approved 
 
Regulatory Clearance Status from DCGI  
Status 
Not Applicable 
 
Health Condition / Problems Studied  
Health Type  Condition 
Healthy Human Volunteers  Healthy and physically fit individuals who regularly participate in physical activity or exercise will be included. 
 
Intervention / Comparator Agent  
Type  Name  Details 
Intervention  Nil  Nil 
Intervention  Nil  Nil 
 
Inclusion Criteria  
Age From  20.00 Year(s)
Age To  25.00 Year(s)
Gender  Male 
Details  Male participants aged between 20-25 years with minimum four years’ regular involvement in physical activity or exercise at least five days in a week for two hours each day were assigned as subjects in this study. 
 
ExclusionCriteria 
Details  Individuals with any chronic health conditions, injuries, or medical disorders were not considered in the present study. 
 
Method of Generating Random Sequence   Not Applicable 
Method of Concealment   Not Applicable 
Blinding/Masking   Not Applicable 
Primary Outcome  
Outcome  TimePoints 
Young adults will be positively associated with better executive function performance and higher BDNF. Cortisol may show negative association with both cardiopulmonary fitness and executive functions. GABA may show variable association with executive functions and fitness. The study will demonstrate a favorable neurocognitive and neurochemical profile with better cardiopulmonary fitness, highlighting significant correlations among fitness, brain-related neurochemicals, and executive functioning.  Male participants aged between 20-25 years with minimum four years’ regular involvement in physical activity or exercise at least five days in a week for two hours each day were assigned as subjects in this study. 
 
Secondary Outcome  
Outcome  TimePoints 
To examine the associations between cardio-pulmonary fitness, executive function performance, & selected neurochemical variables (BDNF, GABA, & cortisol) in young adults, & to evaluate the potential mediating role of these neurochemical variables in the relationship between cardio-pulmonary fitness & executive functions.  Male participants aged between 20-25 years with minimum four years’ regular involvement in physical activity or exercise at least five days in a week for two hours each day were assigned as subjects in this study. 
 
Target Sample Size   Total Sample Size="100"
Sample Size from India="100" 
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" 
Phase of Trial   N/A 
Date of First Enrollment (India)   05/03/2026 
Date of Study Completion (India) Applicable only for Completed/Terminated trials 
Date of First Enrollment (Global)  Date Missing 
Date of Study Completion (Global) Applicable only for Completed/Terminated trials 
Estimated Duration of Trial   Years="0"
Months="2"
Days="5" 
Recruitment Status of Trial (Global)   Not Applicable 
Recruitment Status of Trial (India)  Not Yet Recruiting 
Publication Details   N/A 
Individual Participant Data (IPD) Sharing Statement

Will individual participant data (IPD) be shared publicly (including data dictionaries)?  

Response - NO
Brief Summary   The proposed study aims to investigate the interrelationships among cardio pulmonary fitness, executive functions, and selected neurochemical variables (BDNF, GABA, and Cortisol) in young adults. using a triangulation research design.With growing evidence linking physical activity to cognitive and neurochemical health, this study seeks to bridge physiological, cognitive, and biochemical perspectives to better understand the holistic impact of regular exercise. This approach aligns with the biopsychosocial model of health, an emergent paradigm in preventive and population medicine that emphasizes the integration of biological, psychological, an social factors in understanding health and illness. By conserdering neurochemical profiles , cognitive functions, and physical activity patterns, the study reflects a holistic framework that is crucial for addressing complex public health challenges and promoting sustainable well- being. 
In this study, a single group of regular exercisers aged 20 to 25 years’ will be included. Cardio pulmonary fitness will be assessed using VO2 Max testing through sandardized treadmill protocols. Executive functions will be measured by using validated neuropsychological tests such as Stroop clor and word test(SCWT), Trail making test (TMT), and Tower oh Hanoi test. Neurochemical variables (BDNF, GABA and Cortisol) will be analysed through blood samples using ELISA kits. The study is grounded in a triangulation methodology, integrating quantitative physiological , cognitive and biochemical data to provide a comprehensive view of how regular activity influences brain function and stress response. It is hypothesized that regular exercise and physical activity will exhibit higher levels of cardiopulmonary fitness, improved executive function performance, increased concentration of BDNF and GABA, and lower cortisol levels.
 
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