Population based studies estimate the global prevalence of Irritable Bowel Syndrome is 10 to 20 percentage and incidence is at 1 to 2 percentage. It is one of the most common conditions encountered in the clinical practice as well as is least understood. K58.9 is a billable or specific ICD 10 CM code that can be used to indicate a diagnosis for Irritable Bowel Syndrome. In contemporary science, IBS is managed by means of patient counseling and dietary alterations, stool bulking agents, antispasmodics, anti diarrheal, anti depressants, anti flatulent therapy and gut serotonin receptors. But which may lead to the adverse effects like xerostomia, urinary hesitancy and retention, blurred vision, drowsiness, dependency on drugs. So, while considering its pathology and adverse effects of drug, its better to adopt a treatment which will manage or reverse the pathology, prevent recurrence, and to ensure non occurrence of the above mentioned adverse effects. As in the Grahani Agnimandhya is important factor in the samprapti, so it should be treated with Agnivardhana yogas. Therefore Lavangadi churna is selected as trial drug. Bruhat Gangadhara churna, which is a proven drug, in Grahani roga with special reference to Irritable bowel syndrome is taken as control drug. Hence here an attempt has been made to evaluate the comparative clinical study of Lavangadi Churna and Bruhat Gangadhara Churna in the management of Grahani. Lavangadi Churna has 19 drugs. Most of the drugs are having Katu and Kashaya rasa, Laghu  and Ruksha guna, Ushna veerya, katu vipaka, Ama pachaka and Agni Deepana properties, which might help in the Samprapti vighatana of Grahani roga. Hence the current study is undertaken.