The study titled “Efficacy of Individualized Homoeopathic Medicines in Persistent and Perennial Allergic Rhinitis” is a double-blind, randomized, placebo-controlled clinical trial conducted at NHMC, Lucknow. It aims to evaluate the effectiveness of individualized homoeopathic medicines compared to placebo in improving symptoms and quality of life among patients with persistent and perennial allergic rhinitis. A total of 140 participants, aged between 18 and 65 years, were enrolled according to specific inclusion and exclusion criteria and randomly assigned to two parallel groups — experimental (individualized homoeopathic medicines in centesimal potencies) and control (indistinguishable placebo) groups.

Randomization was carried out using a computer-generated random number chart, ensuring equal allocation and minimizing selection bias. Both the participants and investigators were blinded to the treatment assignment to maintain the integrity of the trial. Participants were followed for three months, during which both subjective and objective outcomes were recorded and were regularly followed up to monitor symptom changes and treatment responses. The primary outcome was assessed using the Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ), while secondary outcomes included Visual Analogue Scale (VAS) scores for nasal and non-nasal symptoms, along with overall quality-of-life assessment. Ethical approval, informed consent, and prospective trial registration were obtained. The study design ensures methodological rigor and aims to determine whether individualized homoeopathic treatment offers a statistically significant advantage over placebo in managing allergic rhinitis.