1. What data in particular will be shared?
   Response - Individual participant data that underlie the results reported in this article, after de-identification (text, tables, figures, and appendices).
   


2. What additional supporting information will be shared?
   Response -  Study Protocol
   Response -  Statistical Analysis Plan
   
   
3. Who will be able to view these files?
   Response (Others) -  Researchers who are interested in topic and whose use of data has been approved by independent review committee.


4. For what types of analyses will this data be available?
   Response - For individual participant data meta-analysis.
   


5. By what mechanism will data be made available?
   Response - Proposals should be directed to [renushilimkar61@gmail.com].
   


6. For how long will this data be available start date provided 30-07-2028 and end date provided 29-01-2029?
   Response (Others) -  6 months from the date of publication


7. Any URL or additional information regarding plan/policy for sharing IPD? 
   Additional Information - NIL

The study titled as Comparison of effects of Remifentanil and Fentanyl on hemodynamics and recovery in patients undergoing elective craniotomy under general anesthesia a prospective observational double blind study aims to determine whether remifentanil is superior to fentanyl in terms of maintaining hemodynamic stability and improving recovery in patients undergoing elective craniotomies. Craniotomy procedures require precise anesthesia management to ensure intraoperative stability and allow for early postoperative neurological assessment. Fentanyl, a commonly used opioid, has a longer half-life which may delay recovery, while remifentanil, due to its ultra short acting nature and unique metabolism, allows for quicker emergence. However, remifentanil provides minimal postoperative analgesia and its use in India has been relatively recent. This study seeks to fill the gap in Indian data by comparing the intraoperative and postoperative effects of these two drugs. The primary objectives are to compare the effects of remifentanil and fentanyl on intraoperative hemodynamics and recovery. The secondary objective is to assess additional analgesic requirements in the immediate postoperative period and observe any complications. This will be a prospective randomized double blind controlled trial conducted at PD Hinduja Hospital and MRC Mahim with a total sample size of 100 patients divided equally into two groups over 18 months. Patients aged 18 to 80 years undergoing elective craniotomy under general anesthesia will be included. After obtaining informed consent and completing a preoperative evaluation, patients will be randomized using computer generated chits into two groups: Group R receiving Remifentanil infusion and saline bolus, and Group F receiving Fentanyl bolus and saline infusion. Anesthesia for both groups will be standardized using Propofol, Sevoflurane and Vecuronium. Hemodynamic parameters will be recorded at specified intervals and postoperative outcomes such as recovery time pain scores and rescue analgesia needs will be evaluated. It is anticipated that remifentanil will offer better hemodynamic control and faster recovery than fentanyl. The study findings may offer insights into optimizing neurosurgical anesthesia practices for Indian patients by highlighting the comparative benefits of these two opioids.