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CTRI Number  CTRI/2025/11/097153 [Registered on: 11/11/2025] Trial Registered Prospectively
Last Modified On: 11/11/2025
Post Graduate Thesis  Yes 
Type of Trial  Interventional 
Type of Study   Medical Device 
Study Design  Randomized, Parallel Group Trial 
Public Title of Study   Comparison of two techniques for placing an intrauterine device after child birth during cesarean section 
Scientific Title of Study   Comparison of modified introducer withdrawal technique with conventional manual technique of post placental intrauterine device insertion during cesarean section: a randomised controlled trial 
Trial Acronym  NIL 
Secondary IDs if Any  
Secondary ID  Identifier 
NIL  NIL 
 
Details of Principal Investigator or overall Trial Coordinator (multi-center study)  
Name  Dr Rakhi Singh 
Designation  Postgraduate Student 
Affiliation  University College of Medical Sciences and GTB Hospital 
Address  Department of Obstetrics and Gynaecology, MCH Building, 7th Floor, UCMS and GTB Hospital

East
DELHI
110095
India 
Phone  9717844684  
Fax    
Email  rakhi10dhankhar@gmail.com  
 
Details of Contact Person
Scientific Query
 
Name  Dr Rashmi 
Designation  Professor 
Affiliation  University College of Medical Sciences and GTB Hospital 
Address  Department of Obstetrics and Gynaecology, MCH Building, 7th Floor, UCMS and GTB Hospital

East
DELHI
110095
India 
Phone  9810645212  
Fax    
Email  rashmi.malik2011@gmail.com  
 
Details of Contact Person
Public Query
 
Name  Dr Rakhi Singh 
Designation  Postgraduate Student 
Affiliation  University College of Medical Sciences and GTB Hospital 
Address  Department of Obstetrics and Gynaecology, MCH Building, 7th Floor, UCMS and GTB Hospital

East
DELHI
110095
India 
Phone  9717844684  
Fax    
Email  rakhi10dhankhar@gmail.com  
 
Source of Monetary or Material Support  
NIL 
 
Primary Sponsor  
Name  University College of Medical Sciences and Guru Teg Bahadur Hospital 
Address  University College of Medical Sciences and GTB Hospital, Delhi 110095 India 
Type of Sponsor  Government medical college 
 
Details of Secondary Sponsor  
Name  Address 
NIL  NIL 
 
Countries of Recruitment     India  
Sites of Study  
No of Sites = 1  
Name of Principal Investigator  Name of Site  Site Address  Phone/Fax/Email 
Dr Rakhi Singh  UCMS and GTB Hospital  Gynaecology Emergency Operation Theatre, MCH Building, 1st Floor, UCMS and GTB Hospital
East
DELHI 
9717844684

rakhi10dhankhar@gmail.com 
 
Details of Ethics Committee  
No of Ethics Committees= 1  
Name of Committee  Approval Status 
Institutional Ethics Committee Human Research, UCMS  Approved 
 
Regulatory Clearance Status from DCGI  
Status 
Not Applicable 
 
Health Condition / Problems Studied  
Health Type  Condition 
Patients  (1) ICD-10 Condition: O82||Encounter for cesarean delivery without indication, (2) ICD-10 Condition: O998||Other specified diseases and conditions complicating pregnancy, childbirth and the puerperium,  
 
Intervention / Comparator Agent  
Type  Name  Details 
Intervention  Introducer Withdrawal Technique of PPIUCD insertion  During cesarean section, IUCD will be inserted post-placental using Modified Introducer Withdrawal Technique and evaluation will be done at 1 week, 6 weeks and at 3 months 
Comparator Agent  Manual technique PPIUCD insertion  During cesarean section, IUCD will be inserted post-placental using Manual technique and evaluation will be done at 1 week, 6 weeks and at 3 months 
 
Inclusion Criteria  
Age From  18.00 Year(s)
Age To  45.00 Year(s)
Gender  Female 
Details  Pregnant women age 18-45 yrs planned for elective or emergency caesarean section, consenting for an IUCD to be inserted immediately after placental removal. 
 
ExclusionCriteria 
Details  - Prolonged Ruptured Of Membranes more than 18hrs
- Chorioamnionitis
- Unresolved postpartum haemorrhage
- Extensive genital trauma
- Any contraindication for Cu IUCD 
 
Method of Generating Random Sequence   Computer generated randomization 
Method of Concealment   Not Applicable 
Blinding/Masking   Not Applicable 
Primary Outcome  
Outcome  TimePoints 
- Percentage of women with visible threads on Per Speculum examination at 6 weeks and 3 months postpartum in both the groups and then comparison will be done
- Percentage of women with normally placed PPIUD (intracavitary) at 7 days and 6 weeks postpartum and then comparison will be done 
7 days, 6 weeks and 3 months  
 
Secondary Outcome  
Outcome  TimePoints 
- Comparison of insertion time between two groups.
- Comparison of Incidence of following conditions between two groups:-
1. Expulsion Rate in percentage between two groups
2. Pain by VAS scale
3. Irregular bleeding
4. Infection
 
After delivery & till 3 months 
 
Target Sample Size   Total Sample Size="130"
Sample Size from India="130" 
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" 
Phase of Trial   Phase 4 
Date of First Enrollment (India)   22/11/2025 
Date of Study Completion (India) Applicable only for Completed/Terminated trials 
Date of First Enrollment (Global)  Date Missing 
Date of Study Completion (Global) Applicable only for Completed/Terminated trials 
Estimated Duration of Trial   Years="1"
Months="0"
Days="0" 
Recruitment Status of Trial (Global)   Not Applicable 
Recruitment Status of Trial (India)  Not Yet Recruiting 
Publication Details   N/A 
Individual Participant Data (IPD) Sharing Statement

Will individual participant data (IPD) be shared publicly (including data dictionaries)?  

Response - NO
Brief Summary  
RATIONALE
In this modified technique there is use of introducer withdrawal technique of IUCD insertion so that threads are directed to the cervical canal
Pushing the IUCDs unfolded arms up to the fundus with an introducer guarantees that the arms are securely in the uterine fundus

AIM
Comparison of modified introducer withdrawal technique of IUCD insertion versus conventional manual PPIUCD insertion technique during cesarean section on postpartum visibility of thread and correct placement of IUCD

OBJECTIVES
Primary objective
To compare visibility of thread at the end of puerperium at 6 weeks and three months between two techniques of PPIUCD insertion during cesarean section withdrawal technique versus conventional manual technique
To compare accuracy of fundal placement of IUCD after 1 week and 6 weeks of PPIUCD insertion between two techniques using ultrasound

Secondary objectives
To compare following conditions after 6 weeks and 3 months of PPIUD insertion by both techniques during cesarean section
1 Expulsion
2 Pain by VAS Scoring
3 Irregular Bleeding
4 Infection
To compare insertion time between 2 groups

MATERIALS AND METHODS
Study Design Randomised Control Trial
Setting The study will be conducted in the Department of Obstetrics and Gynaecology University College of Medical Sciences and Guru Teg Bahadur Hospital Dilshad Garden Delhi
Duration 1st August 2025 to 30th November 2026

Inclusion criteria
Pregnant women age 18 to 45 years planned for elective or emergency cesarean section consenting for an IUCD to be inserted immediately after placental removal

Exclusion criteria
Prolonged Ruptured Of Membranes more than 18 hours
Chorioamnionitis
Unresolved postpartum haemorrhage
Extensive genital trauma
Any contraindication for Cu IUCD

SAMPLE SIZE
The minimum sample size is estimated based on study conducted by Dabian et al reporting the outcome of interest considering visibility of threads were 885 percent in modified technique versus 603 percent in traditional method At two tail alternative hypothesis level of significance 5 percent power of test 95 percent and with equal allocations in both the groups the minimum sample size came out to be 130 including both the groups allocating 65 in each group

METHODOLOGY
Ethical clearance will be taken from the IEC HR
130 Pregnant women 18 to 45 years of age presenting with an indication for emergency or elective caesarean section and wants PPIUCD insertion will be randomized into two groups 65 each after written and informed consent Baseline demographics investigations like CBC URM GCT HIV Anti HCV VDRL LFT physical and obstetrics examination will be recorded
Group A will consist of 65 women who will receive PPIUCD insertion using the modified introducer withdrawal technique
Group B will consist of 65 women who will receive PPIUCD insertion using conventional manual technique
Follow up will be done at 7 to 10 days postpartum 6 weeks postpartum 3 months postpartum
Ultrasound will be done 7 to 10 days postpartum to confirm intracavitary position of IUCD and expulsion
At 6 weeks per speculum examination will be done to check visibility of threads Transvaginal ultrasound will also be done for correct placement and expulsion Women will be interviewed regarding any complaints
At 3 months postpartum per speculum examination will be done and ultrasound will be done if threads not visible to check expulsion Women will be interviewed regarding any complaints

OUTCOME MEASURES
Primary Outcome Measure
Percentage of women with visible threads on per speculum examination at 6 weeks and 3 months postpartum in both the groups and then comparison will be done
Percentage of women with normally placed PPIUCD at 7 days and 6 weeks postpartum in both the groups and then comparison will be done

Secondary Outcome Measures
Comparison of insertion time between two groups
Comparison of incidence of following conditions between two groups
1 Expulsion rate in percentage between two groups
2 Pain by VAS scale
3 Irregular bleeding
4 Infection

STATISTICAL ANALYSIS
Descriptive statistics based on qualitative and quantitative variables
The normality of the continuous data set will be assessed with Kolmogorov Smirnov test
Categorical variables will be analysed using the Chi square test
P value less than 005 will be considered statistically significant
All the analysis will be performed by using SPSS version 200
 
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