| CTRI Number |
CTRI/2025/10/096390 [Registered on: 23/10/2025] Trial Registered Prospectively |
| Last Modified On: |
22/10/2025 |
| Post Graduate Thesis |
Yes |
| Type of Trial |
Observational |
|
Type of Study
|
Cross Sectional Study |
| Study Design |
Other |
|
Public Title of Study
|
Can the ultrasound scan of femoral artery predict the quality of chest compressions in cardiac arrest patients |
|
Scientific Title of Study
|
Clinical utility of Femoral Artery Collapse Ratio for predicting
the quality of chest compression among Cardiac Arrest Patients
A prospective observational study |
| Trial Acronym |
Nil |
|
Secondary IDs if Any
|
| Secondary ID |
Identifier |
| Nil |
NIL |
|
|
Details of Principal Investigator or overall Trial Coordinator (multi-center study)
|
| Name |
Shiva roobini R |
| Designation |
Junior resident |
| Affiliation |
JIPMER |
| Address |
Department of emergency medicine and trauma, Jawaharlal Institute of postgraduate medical education and research, Dhanvantri nagar, pondicherry
Pondicherry PONDICHERRY 605006 India |
| Phone |
8870115349 |
| Fax |
|
| Email |
shivaroobiniravi@gmail.com |
|
Details of Contact Person Scientific Query
|
| Name |
Amrithanand V T |
| Designation |
Assistant professor |
| Affiliation |
JIPMER |
| Address |
Department of emergency medicine and trauma, Jawaharlal institute of postgraduate medical education and research, Dhanvantri nagar, pondicherry
Pondicherry PONDICHERRY 605006 India |
| Phone |
919013590856 |
| Fax |
|
| Email |
amrithanandvt@gmail.com |
|
Details of Contact Person Public Query
|
| Name |
Amrithanand V T |
| Designation |
Assistant professor |
| Affiliation |
JIPMER |
| Address |
Department of emergency medicine and trauma, Jawaharlal institute of postgraduate medical education and research, Dhanvantri nagar, pondicherry
Pondicherry PONDICHERRY 605006 India |
| Phone |
919013590856 |
| Fax |
|
| Email |
amrithanandvt@gmail.com |
|
|
Source of Monetary or Material Support
|
| Jawaharlal Institute of Postgraduate Medical Education and
Research, Pondicherry 605006,India |
|
|
Primary Sponsor
|
| Name |
Jawaharlal Institute of Postgraduate Medical Education and Research |
| Address |
Jawaharlal Institute of Postgraduate Medical Education and
Research, Dhanvantri nagar, pondicherry |
| Type of Sponsor |
Research institution and hospital |
|
|
Details of Secondary Sponsor
|
|
|
Countries of Recruitment
|
India |
|
Sites of Study
|
| No of Sites = 1 |
| Name of Principal
Investigator |
Name of Site |
Site Address |
Phone/Fax/Email |
| Dr Shiva roobini R |
Jawaharlal institute of postgraduate medical education and research |
No 7, Department of Emergency medicine and Trauma, Emergency Medicine division, First Floor EMSD Building,
DHANVANTRI NAGAR Pondicherry PONDICHERRY |
8870115349
shivaroobiniravi@gmail.com |
|
|
Details of Ethics Committee
|
| No of Ethics Committees= 1 |
| Name of Committee |
Approval Status |
| INSTITUTIONAL ETHICS COMMITTEE FOR OBSERVATIONAL STUDIES |
Approved |
|
|
Regulatory Clearance Status from DCGI
|
|
|
Health Condition / Problems Studied
|
| Health Type |
Condition |
| Patients |
(1) ICD-10 Condition: I462||Cardiac arrest due to underlying cardiac condition, |
|
|
Intervention / Comparator Agent
|
| Type |
Name |
Details |
| Intervention |
Nil |
Nil |
| Intervention |
Nil |
Nil |
| Intervention |
Nil |
Nil |
| Intervention |
Nil |
Nil |
|
|
Inclusion Criteria
|
| Age From |
18.00 Year(s) |
| Age To |
99.00 Year(s) |
| Gender |
Both |
| Details |
Adult cardiac arrest patients with age more than 18 years
Intubated with End tidal CO2 monitoring |
|
| ExclusionCriteria |
| Details |
1.pelvic trauma patients
2.attained return of spontaneous circulation before obtaining scan values
3.pregnant women
4.known femoral artery pathology like dissection or stenosis or thrombosis
4.blockage of end tidal co2 sampling tubes with secretions |
|
|
Method of Generating Random Sequence
|
Not Applicable |
|
Method of Concealment
|
Not Applicable |
|
Blinding/Masking
|
Not Applicable |
|
Primary Outcome
|
| Outcome |
TimePoints |
To assess the clinical utility of Femoral Artery
Collapse Ratio for predicting the quality of chest
compressions among cardiac arrest patients |
During initial 2 minutes of chest compressions after intubation |
|
|
Secondary Outcome
|
| Outcome |
TimePoints |
To identify the association of Femoral Artery
Collapse Ratio with Return of Spontaneous
Circulation |
During chest compressions after intubation until return of spontaneous circulation/patient being declared dead |
|
|
Target Sample Size
|
Total Sample Size="128" Sample Size from India="128"
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" |
|
Phase of Trial
|
N/A |
|
Date of First Enrollment (India)
|
15/11/2025 |
| Date of Study Completion (India) |
Applicable only for Completed/Terminated trials |
| Date of First Enrollment (Global) |
Date Missing |
| Date of Study Completion (Global) |
Applicable only for Completed/Terminated trials |
|
Estimated Duration of Trial
|
Years="1" Months="6" Days="0" |
|
Recruitment Status of Trial (Global)
|
Not Yet Recruiting |
| Recruitment Status of Trial (India) |
Not Yet Recruiting |
|
Publication Details
|
N/A |
|
Individual Participant Data (IPD) Sharing Statement
|
Will individual participant data (IPD) be shared publicly (including data dictionaries)?
Response - NO
|
|
Brief Summary
|
The delivery of high-quality cardiopulmonary resuscitation is a pivotal determinant of survival and neurological recovery in patients experiencing cardiac arrest. The effectiveness of resuscitation is contingent upon the adequacy of chest compressions in generating sufficient cardiac output and maintaining perfusion to vital organs. Conventional parameter used to evaluate the quality of cardiopulmonary resuscitation, such as invasive arterial pressure measurement, are constrained by practical and physiological limitations. Invasive arterial pressure monitoring requires invasive catheterization, which is not always feasible in emergency circumstances. These limitations underscore the need for a non-invasive, objective, and reproducible surrogate measure for real-time assessment of resuscitation quality. The Femoral Artery Collapse Ratio, determined using point-of-care ultrasonography, has recently emerged as a promising alternative. This ratio, derived from systolic and diastolic diameters of the femoral artery obtained in motion-mode imaging, reflects dynamic arterial changes during compressions and may correlate with perfusion indices. Preliminary evidence from porcine model demonstrates a positive association between the femoral artery collapse ratio and end-tidal carbon dioxide, suggesting potential clinical applicability. This prospective observational study will be undertaken in the Department of Emergency Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry. A total of one hundred and twenty-eight adult cardiac arrest patients undergoing advanced cardiac life support will be enrolled. Femoral artery ultrasonography and side stream capnography will be simultaneously performed during resuscitation to record arterial diameters and carbon dioxide values. Statistical analysis will evaluate correlations between the femoral artery collapse ratio, end-tidal carbon dioxide, and return of spontaneous circulation. Validation of this parameter could establish the femoral artery collapse ratio as a novel, non-invasive, and physiologically meaningful indicator for real-time monitoring of cardiopulmonary resuscitation quality. |