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CTRI Number  CTRI/2025/10/096390 [Registered on: 23/10/2025] Trial Registered Prospectively
Last Modified On: 22/10/2025
Post Graduate Thesis  Yes 
Type of Trial  Observational 
Type of Study   Cross Sectional Study 
Study Design  Other 
Public Title of Study   Can the ultrasound scan of femoral artery predict the quality of chest compressions in cardiac arrest patients 
Scientific Title of Study   Clinical utility of Femoral Artery Collapse Ratio for predicting the quality of chest compression among Cardiac Arrest Patients A prospective observational study 
Trial Acronym  Nil 
Secondary IDs if Any  
Secondary ID  Identifier 
Nil  NIL 
 
Details of Principal Investigator or overall Trial Coordinator (multi-center study)  
Name  Shiva roobini R 
Designation  Junior resident 
Affiliation  JIPMER 
Address  Department of emergency medicine and trauma, Jawaharlal Institute of postgraduate medical education and research, Dhanvantri nagar, pondicherry

Pondicherry
PONDICHERRY
605006
India 
Phone  8870115349  
Fax    
Email  shivaroobiniravi@gmail.com  
 
Details of Contact Person
Scientific Query
 
Name  Amrithanand V T 
Designation  Assistant professor 
Affiliation  JIPMER 
Address  Department of emergency medicine and trauma, Jawaharlal institute of postgraduate medical education and research, Dhanvantri nagar, pondicherry

Pondicherry
PONDICHERRY
605006
India 
Phone  919013590856  
Fax    
Email  amrithanandvt@gmail.com  
 
Details of Contact Person
Public Query
 
Name  Amrithanand V T 
Designation  Assistant professor 
Affiliation  JIPMER 
Address  Department of emergency medicine and trauma, Jawaharlal institute of postgraduate medical education and research, Dhanvantri nagar, pondicherry

Pondicherry
PONDICHERRY
605006
India 
Phone  919013590856  
Fax    
Email  amrithanandvt@gmail.com  
 
Source of Monetary or Material Support  
Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry 605006,India 
 
Primary Sponsor  
Name  Jawaharlal Institute of Postgraduate Medical Education and Research 
Address  Jawaharlal Institute of Postgraduate Medical Education and Research, Dhanvantri nagar, pondicherry 
Type of Sponsor  Research institution and hospital 
 
Details of Secondary Sponsor  
Name  Address 
Nil  Nil 
 
Countries of Recruitment     India  
Sites of Study  
No of Sites = 1  
Name of Principal Investigator  Name of Site  Site Address  Phone/Fax/Email 
Dr Shiva roobini R  Jawaharlal institute of postgraduate medical education and research   No 7, Department of Emergency medicine and Trauma, Emergency Medicine division, First Floor EMSD Building, DHANVANTRI NAGAR
Pondicherry
PONDICHERRY 
8870115349

shivaroobiniravi@gmail.com 
 
Details of Ethics Committee  
No of Ethics Committees= 1  
Name of Committee  Approval Status 
INSTITUTIONAL ETHICS COMMITTEE FOR OBSERVATIONAL STUDIES   Approved 
 
Regulatory Clearance Status from DCGI  
Status 
Not Applicable 
 
Health Condition / Problems Studied  
Health Type  Condition 
Patients  (1) ICD-10 Condition: I462||Cardiac arrest due to underlying cardiac condition,  
 
Intervention / Comparator Agent  
Type  Name  Details 
Intervention  Nil  Nil 
Intervention  Nil  Nil 
Intervention  Nil  Nil 
Intervention  Nil  Nil 
 
Inclusion Criteria  
Age From  18.00 Year(s)
Age To  99.00 Year(s)
Gender  Both 
Details  Adult cardiac arrest patients with age more than 18 years

Intubated with End tidal CO2 monitoring 
 
ExclusionCriteria 
Details  1.pelvic trauma patients
2.attained return of spontaneous circulation before obtaining scan values
3.pregnant women
4.known femoral artery pathology like dissection or stenosis or thrombosis
4.blockage of end tidal co2 sampling tubes with secretions  
 
Method of Generating Random Sequence   Not Applicable 
Method of Concealment   Not Applicable 
Blinding/Masking   Not Applicable 
Primary Outcome  
Outcome  TimePoints 
To assess the clinical utility of Femoral Artery
Collapse Ratio for predicting the quality of chest
compressions among cardiac arrest patients 
During initial 2 minutes of chest compressions after intubation  
 
Secondary Outcome  
Outcome  TimePoints 
To identify the association of Femoral Artery
Collapse Ratio with Return of Spontaneous
Circulation 
During chest compressions after intubation until return of spontaneous circulation/patient being declared dead  
 
Target Sample Size   Total Sample Size="128"
Sample Size from India="128" 
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" 
Phase of Trial   N/A 
Date of First Enrollment (India)   15/11/2025 
Date of Study Completion (India) Applicable only for Completed/Terminated trials 
Date of First Enrollment (Global)  Date Missing 
Date of Study Completion (Global) Applicable only for Completed/Terminated trials 
Estimated Duration of Trial   Years="1"
Months="6"
Days="0" 
Recruitment Status of Trial (Global)   Not Yet Recruiting 
Recruitment Status of Trial (India)  Not Yet Recruiting 
Publication Details   N/A 
Individual Participant Data (IPD) Sharing Statement

Will individual participant data (IPD) be shared publicly (including data dictionaries)?  

Response - NO
Brief Summary  

The delivery of high-quality cardiopulmonary resuscitation is a pivotal determinant of survival and neurological recovery in patients experiencing cardiac arrest. The effectiveness of resuscitation is contingent upon the adequacy of chest compressions in generating sufficient cardiac output and maintaining perfusion to vital organs. Conventional parameter used to evaluate the quality of cardiopulmonary resuscitation, such as invasive arterial pressure measurement, are constrained by practical and physiological limitations. Invasive arterial pressure monitoring requires invasive catheterization, which is not always feasible in emergency circumstances. These limitations underscore the need for a non-invasive, objective, and reproducible surrogate measure for real-time assessment of resuscitation quality.

The Femoral Artery Collapse Ratio, determined using point-of-care ultrasonography, has recently emerged as a promising alternative. This ratio, derived from systolic and diastolic diameters of the femoral artery obtained in motion-mode imaging, reflects dynamic arterial changes during compressions and may correlate with perfusion indices. Preliminary evidence from porcine model demonstrates a positive association between the femoral artery collapse ratio and end-tidal carbon dioxide, suggesting potential clinical applicability.

This prospective observational study will be undertaken in the Department of Emergency Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry. A total of one hundred and twenty-eight adult cardiac arrest patients undergoing advanced cardiac life support will be enrolled. Femoral artery ultrasonography and side stream capnography will be simultaneously performed during resuscitation to record arterial diameters and carbon dioxide values. Statistical analysis will evaluate correlations between the femoral artery collapse ratio, end-tidal carbon dioxide, and return of spontaneous circulation.

Validation of this parameter could establish the femoral artery collapse ratio as a novel, non-invasive, and physiologically meaningful indicator for real-time monitoring of cardiopulmonary resuscitation quality.

 
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