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CTRI Number  CTRI/2025/10/095836 [Registered on: 09/10/2025] Trial Registered Prospectively
Last Modified On: 09/10/2025
Post Graduate Thesis  Yes 
Type of Trial  Interventional 
Type of Study   Homeopathy 
Study Design  Other 
Public Title of Study   To study the Utility Of Rubrics From Homoeopathic Medical Repertory By Dr. Robin Murphy In The Management Of Acne Vulgaris (Grade I, II, III) 
Scientific Title of Study   Utility Of Rubrics From Homoeopathic Medical Repertory By Dr. Robin Murphy In The Management Of Acne Vulgaris (Grade I, II, III) Among Age Group Of 16-25 Years: An Experimental Non-Controlled Study 
Trial Acronym  nil 
Secondary IDs if Any  
Secondary ID  Identifier 
NIL  NIL 
 
Details of Principal Investigator or overall Trial Coordinator (multi-center study)  
Name  Dr Hemangi Vishe 
Designation  PG Student 
Affiliation  Dr G D Pol Foundation Ymt Homoeopathic Medical College Hospital And PG Institute 
Address  Dr G D Pol Foundation YMT Homoeopathic Medical College Hospital And PG Institute Institutional Area Sector 4 Kharghar Navi Mumbai 410210

Raigarh
MAHARASHTRA
410210
India 
Phone  7066569218  
Fax    
Email  hemangivishe1999@gmail.com  
 
Details of Contact Person
Scientific Query  
Name  Dr. Shrutika Sawant 
Designation  HOD Professor 
Affiliation  Dr G D Pol Foundation YMT Homoeopathic Medical College Hospital And PG Institute 
Address  Department of Repertory Dr G D Pol Foundation YMT Homoeopathic Medical College Hospital And PG Institute Institutional Area Sector 4 Kharghar Navi Mumbai 410210

Raigarh
MAHARASHTRA
410210
India 
Phone  9833674469  
Fax    
Email  shruti_0708@gmail.com  
 
Details of Contact Person
Public Query  
Name  Dr Chintan Mehta 
Designation  Associate Professor 
Affiliation  Dr G D Pol Foundation YMT Homoeopathic Medical College Hospital And PG Institute 
Address  Department of Homoeopathic Materia Medica Dr G D Pol Foundation YMT Homoeopathic Medical College Hospital And PG Institute Institutional Area Sector 4 Kharghar Navi Mumbai 410210

Raigarh
MAHARASHTRA
410210
India 
Phone  9869021226  
Fax    
Email  omcvm@yahoo.co.in  
 
Source of Monetary or Material Support  
Dr G D Pol Foundation YMT Homoeopathic Medical College Hospital And PG Institute Institutional Area Sector 4 Kharghar Navi Mumbai 410210 Maharashtra India 
 
Primary Sponsor  
Name  Dr Hemangi Vishe 
Address  Dr G D Pol Foundation YMT Homoeopathic Medical College Hospital And PG Institute Kharghar Navi Mumbai 410210 
Type of Sponsor  Other [Self Sponsored] 
 
Details of Secondary Sponsor  
Name  Address 
NIL  NIL 
 
Countries of Recruitment     India  
Sites of Study  
No of Sites = 1  
Name of Principal Investigator  Name of Site  Site Address  Phone/Fax/Email 
Dr Hemangi Vishe  Dr G D Pol Foundation YMT Homoeopathic Medical College Hospital And PG Institute  OPD No 1 (Medicine) Dr G D Pol Foundation YMT Homoeopathic Medical College Hospital And PG Institute Institutional Area Sector 4 Kharghar Navi Mumbai 410210
Raigarh
MAHARASHTRA 		 7066569218

hemangivishe1999@gmail.com 
 
Details of Ethics Committee  
No of Ethics Committees= 1  
Name of Committee  Approval Status 
Dr G D Pol Foundation YMT Homoeopathic Medical College and Hospital and PG Institute  Approved 
 
Regulatory Clearance Status from DCGI  
Status 
Not Applicable 
 
Health Condition / Problems Studied  
Health Type  Condition 
Patients  (1) ICD-10 Condition: L700||Acne vulgaris,  
 
Intervention / Comparator Agent  
Type  Name  Details 
Intervention  Homoeopathy management using Murphy Repertory  According to Requirement of Patients Health condition Individualised Homeopathic medicine is selected using rubrics from Homoeopathic Medical Repertory By Dr. Robin Murphy and medicine will be prescribed orally and follow ups after 15 days or as per requirement until the relief of symptom of patient 
Comparator Agent  NOT APPLICABLE  NOT APPLICABLE 
 
Inclusion Criteria  
Age From  16.00 Year(s)
Age To  25.00 Year(s)
Gender  Both 
Details  Inclusion Criteria:
1.Clinically diagnosed cases of Acne Vulgaris (Grade I, II, III)
2. Patients of age group 16 to 25 years.
3. Patients of All Genders. 
 
ExclusionCriteria 
Details  Exclusion Criteria:
1. Grade IV Acne Vulgaris.
2. All other variants of acne like Acne conglobate, Acne fulminans, Acne excoriee etc.
3. Patient with complications of Acne Vulgaris like scarring.
4. Patient taking any other local or tropical medications for Acne Vulgaris.
5. Lactating Women or Pregnant Women.
6. Suspected immunocompromised cases. 
 
Method of Generating Random Sequence   Other 
Method of Concealment   Other 
Blinding/Masking   Not Applicable 
Primary Outcome  
Outcome  TimePoints 
Outcome will be assessed in terms of
1 Improved
2 Not improved

These outcome will be assessed as per Pre and Post treatment score according to GAGS scale.  		 1 Duration of study- 18 months
2 Duration of each case- Each case will be studied for 6 months or till recovery occurs, whichever is earlier.
3 Duration of follow up- ease case 15 days and earlier if required.
4 Clinical outcome assessment will be done at baseline of 1 month, 3 months and 6 months 
 
Secondary Outcome  
Outcome  TimePoints 
not applicable  not applicable 
 
Target Sample Size   Total Sample Size="34"
Sample Size from India="34" 
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" 
Phase of Trial   N/A 
Date of First Enrollment (India)   24/10/2025 
Date of Study Completion (India) Applicable only for Completed/Terminated trials 
Date of First Enrollment (Global)  Date Missing 
Date of Study Completion (Global) Applicable only for Completed/Terminated trials 
Estimated Duration of Trial   Years="1"
Months="6"
Days="0" 
Recruitment Status of Trial (Global)   Not Applicable 
Recruitment Status of Trial (India)  Not Yet Recruiting 
Publication Details   N/A 
Individual Participant Data (IPD) Sharing Statement

Will individual participant data (IPD) be shared publicly (including data dictionaries)?  

Response - NO
Brief Summary  

INTRODUCTION

Acne vulgaris commonly affects individuals aged 16 to 25, impacting their physical and psychological wellbeing. Homoeopathy offers a holistic approach and Dr. Robin Murphy’s repertory provides clinically useful rubrics for acne management. This study aims to evaluate the practical utility and effectiveness of these rubrics in managing Grade I, II and III acne through individualized remedy selection. The inflammatory lesions, namely papules, pustules, nodules and cysts, indicate the severity of the disease. The severity of the acne can be graded on clinical grounds as under

Grade I Mild Comedones, occasional papules

Grade II Moderate Comedones, many papules, few pustules.

Grade III Severe Predominantly pustules, nodules and abscesses.

Grade IV Cystic Mainly Cysts or abscesses, widespread scarring

Homoeopathic Medical Repertory, a modern alphabetical repertory is mainly based on ‘Repertory of the Homoeopathic Materia Medica by Dr. J.T. Kent and Repertory of Hering’s Guiding Symptoms of our Materia Medica by Dr. C.B. Kneer. remedies. Dr. Robin Murphy’s Homoeopathic Medical Repertory is a clinically oriented repertory that blends classical and modern perspectives, offering a practical framework for repertorization based on symptom totality. Despite its widespread use in clinical practice, there is limited research evidence evaluating the utility and effectiveness of rubrics from this repertory in managing acne vulgaris.

 AIM AND OBJECTIVE

Primary Objective To study the utility of rubrics from Homeopathic Medical Repertory by Dr. Robin Murphy in Management of Acne Vulgaris Grade I II III among age group of 16  to 25 years.

Other objective

1 To study clinical presentation of Acne Vulgaris Grade I II III among age group of 16 to 25 years.

2 To compare the patient pretreatment score and posttreatment score for Acne Vulgaris Grade I II III on GAGS Scale among age group of 16 to 25 years.

METHODOLOGY

1.     Type of study design An Experimental Noncontrolled Study.

2.     Setting The study will be conducted at the OPD of the institution.

3.     Duration of the study 18 months

4.     Method of selection of study subjects

Inclusion Criteria

1.Clinically diagnosed cases of Acne Vulgaris Grade I II III

2. Patients of age group 16 to 25 years.

3. Patients of All Genders.

Exclusion Criteria

1. Grade IV Acne Vulgaris.

2. All other variants of acne like Acne conglobate, Acne fulminans, Acne excoriee etc.

3. Patient with complications of Acne Vulgaris like scarring.

4. Patient taking any other local or tropical medications for Acne Vulgaris.

5. Lactating Women or Pregnant Women.

6. Suspected immuno compromised cases.

Subject withdrawal criteria

1. Patients who do not wish to continue the treatment.

2. Patients who do not follow up regularly.

3. Patient developing any Medical Emergency.

 Specification of instruments and related measurements:

 1. Homoeopathic Case Taking Proforma will be used in each case.

2. Outcome assessment tool Prevalidated GAGS Scale will be used.

Outcome assessment criteria

a Outcome will be assessed in terms of

Improved if grades of improvement are fair,good or excellent or  greater than or equal to 25 percentage

Not improved if grades of improvement are poor or worse or less than 25 percentage

b) Outcome Pre and Post treatment according to GAGS scale.

Improvement was graded according to the 5 point Global Assessment Scale (GAS).

Grades of improvement by reduction in 5 point global assessment scale (GAS)

1.     Excellent  greater than or equal to 75 percentage improvement in GAS

2.     Good  50 percentage to 74 percentage improvement in GAS

3.     Fair 25 percentage to 49 percentage improvement in GAS

4.     Poor less than 25 percentage improvement in GAS

5.     Worse  Result worse than pre treatment finding.

Sample size 34 patients will be selected.

Sampling technique Nonprobablity Purposive sampling based on inclusion and exclusion criteria

Data management and analysis procedure

1.      Duration of study 18 months

2.     Duration of each  case  Each case will be studiedd upto 6 months or till recovery occurs, whichever is earlier.

3.     Duration of follow up ease case 15 days and earlier if required.

Clinical outcome assessment will be done at baseline of 1 month, 3 months and 6 months


 
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