| CTRI Number |
CTRI/2026/02/103245 [Registered on: 06/02/2026] Trial Registered Prospectively |
| Last Modified On: |
05/02/2026 |
| Post Graduate Thesis |
Yes |
| Type of Trial |
Interventional |
|
Type of Study
|
Homeopathy |
| Study Design |
Single Arm Study |
|
Public Title of Study
|
Homoeopathic treatment for women aged 18–35 with Polycystic Ovary Syndrome (PCOS) using Murphy’s repertory: a study to assess improvement in menstrual regularity and ultrasound findings |
|
Scientific Title of Study
|
The utility of the Mind chapter from Murphys Homoeopathic Medical Repertory in arriving at the simillimum for the treatment of polycystic ovarian syndrome: An experimental study |
| Trial Acronym |
|
|
Secondary IDs if Any
|
| Secondary ID |
Identifier |
| NIL |
NIL |
|
|
Details of Principal Investigator or overall Trial Coordinator (multi-center study)
|
| Name |
Arambya Rajashekar Kalluraya |
| Designation |
Professor |
| Affiliation |
MNR Homoeopathic Medical college |
| Address |
3rd floor, Department of physiology and biochemistry. MNR Homoeopathic Medical college Sangareddy.
Hyderabad
TELANGANA
502294
India |
| Phone |
9440845309 |
| Fax |
|
| Email |
rajsclassicalhomoeopathy@gmail.com |
|
Details of Contact Person
Scientific Query
|
| Name |
DR Anoop Nigwekar |
| Designation |
Professor |
| Affiliation |
Dr. M. L. Dhawale Memorial Homoeopathic Institute |
| Address |
Department of Repertory, Dr. M. L. Dhawale Memorial Homoeopathic Institute, Palghar
Palghar
MAHARASHTRA
401404
India |
| Phone |
9324933032 |
| Fax |
|
| Email |
anoopnigwekar@gmail.com |
|
Details of Contact Person
Public Query
|
| Name |
DR Anoop Nigwekar |
| Designation |
Professor |
| Affiliation |
Dr. M. L. Dhawale Memorial Homoeopathic Institute |
| Address |
Department of Repertory, Dr. M. L. Dhawale Memorial Homoeopathic Institute, Palghar
Palghar
MAHARASHTRA
401404
India |
| Phone |
9324933032 |
| Fax |
|
| Email |
anoopnigwekar@gmail.com |
|
|
Source of Monetary or Material Support
|
|
|
Primary Sponsor
|
| Name |
MNR Homoeopathic Medical college |
| Address |
MNR Nagar Fasalwadi SangaReddy |
| Type of Sponsor |
Private medical college |
|
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Details of Secondary Sponsor
|
|
|
Countries of Recruitment
|
India |
|
Sites of Study
|
| No of Sites = 2 |
| Name of Principal
Investigator |
Name of Site |
Site Address |
Phone/Fax/Email |
| Dr Anoop Nigwekar |
Dr MLDhawale Homoeopathic Medical college and Hospital |
Repertory out patient department.
Palghar
MAHARASHTRA |
9324933032
anoopnigwekar@gmail.com |
| Dr A Rajashekar Kalluraya |
MNR Homoeopathic Medical college and Hospital |
Room no 10, Family medicine clinic, ground floor.
Hyderabad
TELANGANA |
9440845309
rajsclassicalhomoeopathy@gmail.com |
|
|
Details of Ethics Committee
|
| No of Ethics Committees= 2 |
| Name of Committee |
Approval Status |
| Institutional Ethics Committee, MLDMHI, Palghar |
Approved |
| Institutional Ethics Committee, MNRHMCH |
Approved |
|
|
Regulatory Clearance Status from DCGI
|
|
|
Health Condition / Problems Studied
|
| Health Type |
Condition |
| Patients |
(1) ICD-10 Condition: E282||Polycystic ovarian syndrome, (2) ICD-10 Condition: E282||Polycystic ovarian syndrome, |
|
|
Intervention / Comparator Agent
|
| Type |
Name |
Details |
| Intervention |
Individualized homeopathic similimum. |
Indicated Homeopathic medicines in various potencies strictly adhering to homeopathic principles. Daily, weekly, or monthly repetition of dose as the case demands until the end of the study period. Medicines will be administered via oral route. |
| Comparator Agent |
NOT APPLICABLE |
NOT APPLICABLE |
|
|
Inclusion Criteria
|
| Age From |
18.00 Year(s) |
| Age To |
35.00 Year(s) |
| Gender |
Female |
| Details |
Female patients from 18-35 years who fulfil the Rotterdams criteria for PCOS. Known Cases of PCOS with history of PCOS for at least more than 3 months to rule out spontaneous, natural regression of functional cysts. All patients with positive finding of Polycystic ovaries in ultrasound scan, clinical hyperandrogenism and menstrual irregularities oligo or amenorrhea, will be included in the study.
In the beginning of study, each case will be investigated with Abdominopelvic ultrasound scan, FSH, LH, Prolactin & Thyroid profile. A checklist for clinical record will be created to exclude Cushings syndrome, Congenital adrenal hyperplasia, Hyperprolactinemia, Hyperthecosis & Diabetes mellitus. If at all indications of other disease is evident then such cases will not be considered for the study. Patients who are willing to give written informed consent for research participation will be included in the study.
|
|
| ExclusionCriteria |
| Details |
Patients with masculine tumours of adrenal gland or ovary will be excluded.
Patients with Congenital adrenal hyperplasia, Cushing’s syndrome, Hyperprolactinemia, Hyperthecosis are excluded from the study.
Patients with Hypothyroidism, Hyperthyroidism, Diabetes mellitus are also excluded.
PCOS patients with endometrial cancer, Hypertension & other severe cardiovascular complications are excluded from the study.
Patients with other systemic illness are excluded from study.
|
|
|
Method of Generating Random Sequence
|
Not Applicable |
|
Method of Concealment
|
Case Record Numbers |
|
Blinding/Masking
|
Not Applicable |
|
Primary Outcome
|
| Outcome |
TimePoints |
| Change in ovarian morphology, assessed by ultrasonography, measured as change in number of follicles and ovarian volume from baseline to the end of the treatment period, following intervention of individualized homoeopathic similimum by utilising the mind chapter from Murphys repertory. |
Follow-up assessment will be conducted periodically throughout the study period. Patients will be seen every 15 days till menses are regularized. Then onwards every monthly follow-up for symptomatic analysis. USG done before treatment & then onwards every 6 months. |
|
|
Secondary Outcome
|
| Outcome |
TimePoints |
| The outcome of the study may help us to understand the utility and gaps in representation of rubrics and thus bridge the gap that exist in Murphy’s repertory |
Will be assessed throughout the research study period. |
|
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Target Sample Size
|
Total Sample Size="60"
Sample Size from India="60"
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" |
|
Phase of Trial
|
N/A |
|
Date of First Enrollment (India)
|
16/02/2026 |
| Date of Study Completion (India) |
Applicable only for Completed/Terminated trials |
| Date of First Enrollment (Global) |
Date Missing |
| Date of Study Completion (Global) |
Applicable only for Completed/Terminated trials |
|
Estimated Duration of Trial
|
Years="2"
Months="0"
Days="0" |
|
Recruitment Status of Trial (Global)
|
Not Yet Recruiting |
| Recruitment Status of Trial (India) |
Not Yet Recruiting |
|
Publication Details
|
N/A |
|
Individual Participant Data (IPD) Sharing Statement
|
Will individual participant data (IPD) be shared publicly (including data dictionaries)?
Response - NO
|
|
Brief Summary
|
This study investigates the efficacy of individualized homoeopathic treatment in women with Polycystic Ovarian Syndrome PCOS using Murphy’s Homoeopathic Medical Repertory. It focuses on the role of emotional and psychological factors in the development and progression of PCOS and evaluates the adaptability and adequacy of Murphy’s repertory, particularly the mind chapter, in identifying the homoeopathic simillimum. Women diagnosed with PCOS will receive individualized constitutional remedies based on detailed case taking, repertorization, and emotional profiling. Outcomes will be assessed through symptomatic improvement, menstrual regularity, and ultrasonographic changes using Rotterdam criteria, with periodic follow ups and statistical analysis to compare pre and post treatment data. The study also aims to identify any gaps in Murphy’s repertory in addressing emotionally diverse PCOS cases and to determine the overall effectiveness of homoeopathic simillimum in PCOS management. |