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CTRI Number  CTRI/2025/11/098070 [Registered on: 25/11/2025] Trial Registered Prospectively
Last Modified On: 24/11/2025
Post Graduate Thesis  Yes 
Type of Trial  Interventional 
Type of Study   Drug 
Study Design  Other 
Public Title of Study   Comparison between Desflurane Versus Sevoflurane On Post Operative Recovery Profile And Airway Reflexs 
Scientific Title of Study   Comparison Of Efficacy Among Desflurane Versus Sevoflurane On Post Operative Recovery Profile And Airway Reflexs In Patients Under Going General Anaesthesia 
Trial Acronym  NIL 
Secondary IDs if Any  
Secondary ID  Identifier 
NIL  NIL 
 
Details of Principal Investigator or overall Trial Coordinator (multi-center study)  
Name  Dr Anita Pareek 
Designation  Senior Professor 
Affiliation  Sardar Patel Medical College Bikaner, Rajasthan, India 
Address  Department of Anaesthesia Sardar Patel Medical College Bikaner, Rajasthan, India

Bikaner
RAJASTHAN
334001
India 
Phone  9828101281  
Fax    
Email  dranitapareek23@gmail.com  
 
Details of Contact Person
Scientific Query
 
Name  Dr Anita Pareek 
Designation  Senior Professor 
Affiliation  Sardar Patel Medical College Bikaner, Rajasthan, India 
Address  Department of Anaesthesia Sardar Patel Medical College Bikaner, Rajasthan, India

Bikaner
RAJASTHAN
334001
India 
Phone  9828101281  
Fax    
Email  dranitapareek23@gmail.com  
 
Details of Contact Person
Public Query
 
Name  Dr Anita Pareek 
Designation  Senior Professor 
Affiliation  Sardar Patel Medical College Bikaner, Rajasthan, India 
Address  Department of Anaesthesia Sardar Patel Medical College Bikaner, Rajasthan, India

Bikaner
RAJASTHAN
334001
India 
Phone  9828101281  
Fax    
Email  dranitapareek23@gmail.com  
 
Source of Monetary or Material Support  
Department of Anaesthesia SPMC bikaner 
 
Primary Sponsor  
Name  Sardar Patel Medical College Bikaner 
Address  Department Of Anaesthesia Sardar Patel Medical College Bikaner 
Type of Sponsor  Government medical college 
 
Details of Secondary Sponsor  
Name  Address 
NIL  NIL 
 
Countries of Recruitment     India  
Sites of Study  
No of Sites = 1  
Name of Principal Investigator  Name of Site  Site Address  Phone/Fax/Email 
Dr Aditya Kishore  OT A block, Department Of Anaesthesia  Department Of Anaesthesia Sardar Patel Medical College
Bikaner
RAJASTHAN 
09855491027

10adityakishore10@gmail.com 
 
Details of Ethics Committee  
No of Ethics Committees= 1  
Name of Committee  Approval Status 
ETHICS COMMITTEE SPMC MEDICAL COLLEGE BIKANER  Approved 
 
Regulatory Clearance Status from DCGI  
Status 
Not Applicable 
 
Health Condition / Problems Studied  
Health Type  Condition 
Patients  (1) ICD-10 Condition: K807||Calculus of gallbladder and bile duct without cholecystitis,  
 
Intervention / Comparator Agent  
Type  Name  Details 
Comparator Agent  Desflurane versus sevoflurane  post operation recovery and airway reflexs 
Intervention  direct laryngoscopy and tracheal intubation  intra inhalational anaesthic agents 
 
Inclusion Criteria  
Age From  18.00 Year(s)
Age To  65.00 Year(s)
Gender  Both 
Details  ASA 1 Or 2
Elective surgery requiring General Anaesthesia
Written Informed Consent by Patients 
 
ExclusionCriteria 
Details  BMI more than 35 kg/m2
Difficult Intubation
Respiratory Diseases
Preganacy 
 
Method of Generating Random Sequence   Computer generated randomization 
Method of Concealment   Other 
Blinding/Masking   Participant and Investigator Blinded 
Primary Outcome  
Outcome  TimePoints 
Recovery Profile Evaluation
Airway Reflexes Assessment 
At Baseline 
 
Secondary Outcome  
Outcome  TimePoints 
Haemodynamics Variables
Post Anaesthesia Complications
Patient Satisfaction
 
60 min post op 
 
Target Sample Size   Total Sample Size="75"
Sample Size from India="75" 
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" 
Phase of Trial   Phase 4 
Date of First Enrollment (India)   05/12/2025 
Date of Study Completion (India) Applicable only for Completed/Terminated trials 
Date of First Enrollment (Global)  Date Missing 
Date of Study Completion (Global) Applicable only for Completed/Terminated trials 
Estimated Duration of Trial   Years="0"
Months="6"
Days="0" 
Recruitment Status of Trial (Global)   Not Applicable 
Recruitment Status of Trial (India)  Not Yet Recruiting 
Publication Details   N/A 
Individual Participant Data (IPD) Sharing Statement

Will individual participant data (IPD) be shared publicly (including data dictionaries)?  

Response - NO
Brief Summary  

For general anaesthesia, volatile anaesthetics like desflurane and sevoflurane are frequently employed due to their predictability, ease of use and medicinal outcomes. Sevoflurane is frequently used to maintain anaesthesia during day care surgery because of its quick emergence and recovery and comparatively reduced blood gas solubility when compared to other volatile anaesthetics. Furthermore, sevoflurane is frequently employed as an induction agent since it does not irritate the airways, resulting in smooth volatile induction. Since desflurane is the least blood gas soluble of the volatile anaesthetics in the market right now, it’s emergence and recovery are more quickly than sevoflurane. Furthermore, emergence and recovery are linked to desflurane use that is more predictable than sevoflurane. To enable quick and simple anaesthetic induction, dependable intra-operative analgesia, and amnesia, novel medications are used in anaesthesia. Inhalational and volatile liquid anaesthetics are gaining popularity because of how simple it is to administer them and because of how consistently they emerge and recover. Contrary to usual inhalational anaesthetics, desflurane and sevoflurane have low blood-gas partition coefficients. If the patient wakes up more quickly, less time will be spent in the post-anaesthesia care unit and with their airway exposed. The quality of emergence and rate of recovery are impacted by the anaesthetic method chosen. The best general anaesthesia should result in a painless induction, the best possible operating conditions, and a speedy recovery with the fewest possible side effects, such as nausea, vomiting, and postoperative discomfort. Desflurane and sevoflurane, two inhaled general anaesthetics, are used the most frequently due to their simplicity of administration and consistent intraoperative and recovery characteristics. Rapid recovery minimises postoperative respiratory complications and ensures early, effective coughing. Sevoflurane has quick induction and emergence characteristics and a low blood:gas partition coefficient. Studies comparing desflurane and sevoflurane anaesthesia with laryngeal mask airway (LMA) have shown similar rates of: Respiratory illness, with desflurane allowing for faster recovery Gag reflex after emergence, compared with sevoflurane. Some studies reported that desflurane has a consistent and rapid recovery profile in the obese population compared to sevoflurane, isoflurane and propofol. Verma et al in their study concluded patients in the three groups had similar impairments in their psychomotor and cognitive functions which recovered at comparable time periods postoperatively. Emergence and early recovery were, however, faster in the desflurane group. Desflurane is known to have a rapid onset and offset of action, thereby making it possible for the anaesthesiologist to control the depth of anaesthesia rapidly. It also provides haemodynamic stability with preservation of tissue perfusion even in face of hypotension; however it is irritating to the airway and therefore is not routinely utilised for inhalational induction. However, studies have shown that controlled desflurane induction along with opioid premedication can be rapid and well tolerated. Sevoflurane administration has been associated with a smooth, rapid loss of consciousness during inhalation induction and a rapid recovery following discontinuation of anaesthesia. In the present study, a comparison of efficacy between desflurane and sevoflurane will be done to assess postoperative recovery characteristics in patients undergoing general anaesthesia.

 
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