Current knowledge regarding pregabalin’s optimal dosing for preemptive analgesia in spinal anesthesia remains limited and contradictory. While several studies have demonstrated pregabalin’s efficacy in reducing postoperative pain and opioid consumption, there exists significant variability in dosing regimens ranging from 75mg to 600mg, with no consensus on the optimal dose. Most research has focused on general anesthesia, with limited studies specifically evaluating pregabalin’s effects on spinal anesthesia characteristics. Additionally, direct comparative studies between different pregabalin doses in the context of spinal anesthesia for lower abdominal surgeries are scarce. The mechanisms by which pregabalin prolongs motor and sensory blocks in spinal anesthesia are not fully understood, and there remains uncertainty about the dose-response relationship for optimal analgesic efficacy while minimizing adverse effects.

This study aims to bridge this critical knowledge gap by directly comparing two clinically relevant doses of pregabalin (75mg versus 150mg) in patients undergoing lower abdominal surgeries under spinal anesthesia. Such comparative evaluation is essential to establish evidence-based dosing guidelines that maximize analgesic efficacy while minimizing side effects, ultimately improving patient outcomes and optimizing perioperative pain management protocols in this specific surgical population.