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CTRI Number  CTRI/2026/01/101346 [Registered on: 16/01/2026] Trial Registered Prospectively
Last Modified On: 15/01/2026
Post Graduate Thesis  Yes 
Type of Trial  Interventional 
Type of Study   Homeopathy 
Study Design  Single Arm Study 
Public Title of Study   To study the role of Homoeopathy in the management of skin fungal infection. 
Scientific Title of Study   A Clinical Utility of Homeopathic Medical Repertory by Robin Murphy In the Management of Fungal Infection on Skin: A Case Series 
Trial Acronym  NIL 
Secondary IDs if Any  
Secondary ID  Identifier 
NIL  NIL 
 
Details of Principal Investigator or overall Trial Coordinator (multi-center study)  
Name  Dr Harshita Bhagwan Wankhade 
Designation  PG Scholar  
Affiliation  Motiwala National Homeopathic Medical College and Hospital 
Address  Department of Repertory, floor no.4, Motiwala National Homeopathic Medical College and Hospital.

Nashik
MAHARASHTRA
422012
India 
Phone  7798180843  
Fax    
Email  harshitawankhade23@gmail.com  
 
Details of Contact Person
Scientific Query
 
Name  Dr Sarang Suhas Rahalkar  
Designation  Professor  
Affiliation  Motiwala National Homeopathic Medical College and Hospital 
Address  Department of Repertory floor no.4, Motiwala National Homeopathic Medical College and Hospital

Nashik
MAHARASHTRA
422012
India 
Phone  9822303214  
Fax    
Email  sarangrahalkar@gmail.com  
 
Details of Contact Person
Public Query
 
Name  Dr Harshita Bhagwan Wankhade 
Designation  PG Scholar  
Affiliation  Motiwala National Homeopathic Medical College and Hospital 
Address  Department of Repertory floor no.4, Motiwala National Homeopathic Medical College and Hospital

Thane
MAHARASHTRA
422012
India 
Phone  7798180843  
Fax    
Email  harshitawankhade23@gmail.com  
 
Source of Monetary or Material Support  
Motiwala National Homoeopathic Medical College and Hospital, Dhruv nagar Nashik, Maharashtra, India, 422012 
 
Primary Sponsor  
Name  Harshita Bhagwan Wankhade 
Address  Department of homeopathic Repertory and case taking dhruv nagar satpur colony nashik 422012 
Type of Sponsor  Other [self ] 
 
Details of Secondary Sponsor  
Name  Address 
NIL  NIL 
 
Countries of Recruitment     India  
Sites of Study  
No of Sites = 1  
Name of Principal Investigator  Name of Site  Site Address  Phone/Fax/Email 
Dr Harshita Bhagwan Wankhade   Motiwala National Homoeopathic Medical College and Hospital  Department of Repertory and case taking dhruv nagar satpur colony nashik 422012
Nashik
MAHARASHTRA 
7798180843

harshitawankhade23@gmail.com 
 
Details of Ethics Committee  
No of Ethics Committees= 1  
Name of Committee  Approval Status 
Institutional ethical cell motiwala homeopathic medical college   Approved 
 
Regulatory Clearance Status from DCGI  
Status 
Not Applicable 
 
Health Condition / Problems Studied  
Health Type  Condition 
Patients  (1) ICD-10 Condition: B378||Candidiasis of other sites, (2) ICD-10 Condition: B359||Dermatophytosis, unspecified, (3) ICD-10 Condition: B360||Pityriasis versicolor,  
 
Intervention / Comparator Agent  
Type  Name  Details 
Intervention  A Clinical Utility of Homeopathic Medical Repertory by Robin Murphy in the management of fungal infection on skin A case series.  After Homeopathic case taking indicated homeopathic medicines will be prescribe with different potencies according to susceptibility of each patient. Followup will be taken after 15 days or as per need for period of 12 months. The progress will be monitored by Dermatology Life Quality Index Questionnaire DLIQ scale ,before and after the treatment. Homeopathic treatment efficacy will be monitored by MONARCH criteria at the end of the treatment. 
Comparator Agent  NIL   Single Arm Study  
 
Inclusion Criteria  
Age From  16.00 Year(s)
Age To  60.00 Year(s)
Gender  Both 
Details  Patient with skin condition of fungal infection including Dermatophytes Candida Pityriasis versicolor.
Age from 16 years to 60 years.
Patient willing to provide informed consent. 
 
ExclusionCriteria 
Details  Presence of systemic fungal infections.
Non-fungal skin conditions Eczema Psoriasis or bacterial skin infections.
Severe infections Complicated or extensive fungal infections with secondary infections.
Immunocompromised HIV/AIDS Cancer treatments or other immune system disorders.
Consent Not willingness to provide informed consent.
 
 
Method of Generating Random Sequence   Not Applicable 
Method of Concealment   Not Applicable 
Blinding/Masking   Not Applicable 
Primary Outcome  
Outcome  TimePoints 
Improving in patients conditions by prescribing homeopathic medicine using the homeopathic medical repertory and DLQI scale.  On alternative follow up which is to be taken every 15 days or as per need for period within 18 months. 
 
Secondary Outcome  
Outcome  TimePoints 
To find out various rubrics related to fungal infection on skin given in Homeopathic medical repertory by robin murphy.  After 18 months  
 
Target Sample Size   Total Sample Size="40"
Sample Size from India="40" 
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" 
Phase of Trial   N/A 
Date of First Enrollment (India)   30/01/2026 
Date of Study Completion (India) Applicable only for Completed/Terminated trials 
Date of First Enrollment (Global)  Date Missing 
Date of Study Completion (Global) Applicable only for Completed/Terminated trials 
Estimated Duration of Trial   Years="2"
Months="0"
Days="0" 
Recruitment Status of Trial (Global)   Not Applicable 
Recruitment Status of Trial (India)  Not Yet Recruiting 
Publication Details   N/A 
Individual Participant Data (IPD) Sharing Statement

Will individual participant data (IPD) be shared publicly (including data dictionaries)?  

Response - NO
Brief Summary  

Research Gap

Fungal skin infections or superficial mycoses are among the most common dermatological problems worldwide, particularly in tropical and subtropical countries like India. Despite the availability of antifungal drugs, there has been a significant rise in chronic, recurrent, and treatment-resistant fungal infections. Factors such as poor hygiene, humid climate, low socioeconomic conditions, and the widespread misuse of topical steroid–antifungal combinations have contributed to the increasing burden of these infections. This has resulted in altered clinical presentations, prolonged disease course, and frequent relapses across different age groups.

Although homeopathy offers an individualized and holistic treatment approach, there is a lack of structured research evaluating the role of repertorial analysis in the management of fungal skin infections. The Homeopathic Medical Repertory by Robin Murphy contains a wide range of rubrics related to fungal diseases such as tinea, ringworm, candida, and pityriasis versicolor, yet these rubrics have not been systematically studied for their clinical usefulness, accuracy in remedy selection, or treatment outcomes. The absence of evidence-based validation for repertory-guided homeopathic management of fungal skin infections represents a significant research gap. Addressing this gap may help develop a more scientific and standardized approach to homeopathic management of superficial mycoses.

 

Research Question

Is homeopathic treatment effective in the management of fungal skin infections using the Homeopathic Medical Repertory by Robin Murphy?

 

Hypothesis

H1: Homoeopathic treatment is effective in the management of fungal skin infections using the Homeopathic Medical Repertory by Robin Murphy.

H0: Homoeopathic treatment is not effective in the management of fungal skin infections using the Homeopathic Medical Repertory by Robin Murphy.

 

Introduction

Fungal infections of the skin, hair, and nails are an important public health problem affecting millions of people worldwide. According to the World Health Organization, superficial fungal infections affect approximately 20–25% of the global population. These infections are especially common in tropical and subtropical regions due to warm, humid environmental conditions that favor fungal growth. In India, the incidence of dermatophytosis and other superficial mycoses has increased markedly in recent years.

Fungal skin infections not only cause physical symptoms such as itching, redness, scaling, and disfigurement but also have a significant psychological and social impact. Patients may experience embarrassment, low self-esteem, social isolation, and impaired quality of life. The chronic and recurrent nature of many fungal infections further adds to patient distress and economic burden.

Conventional antifungal therapies, though effective in many cases, are often associated with adverse effects, drug resistance, incomplete cure, and frequent relapses. This has created a need for alternative, safe, and holistic systems of medicine. Homeopathy, with its individualized and patient-centered approach, offers potential for managing both the local disease and the underlying susceptibility. The Homeopathic Medical Repertory by Robin Murphy, being a modern and clinically oriented repertory, provides a structured method for selecting remedies based on both clinical diagnosis and totality of symptoms, making it suitable for managing fungal skin infections.

 

Review of Literature

Fungi are eukaryotic organisms that may exist as yeasts, molds, or dimorphic forms. They have distinctive structural and physiological characteristics such as chitin in the cell wall and ergosterol in the cell membrane. Superficial fungal infections primarily affect keratinized tissues like skin, hair, and nails.

The major groups of fungi responsible for skin infections include dermatophytes, Candida, and Malassezia (Pityriasis versicolor). Dermatophytes cause infections such as tinea capitis, tinea corporis, tinea cruris, tinea pedis, tinea manuum, and tinea unguium. These organisms invade keratinized tissues using keratinase enzymes. Host factors such as atopy, diabetes, immunosuppression, sweating, and humid climate increase susceptibility.

Candidiasis commonly affects moist, occluded areas of the skin and mucosa, particularly in infants, elderly, diabetics, and immunocompromised individuals. Pityriasis versicolor is caused by Malassezia furfur and presents as hypopigmented or hyperpigmented scaly patches on the trunk.

Risk factors include excessive sweating, tight clothing, poor hygiene, humid environment, diabetes, immune disorders, and previous fungal infections. Prevention involves maintaining skin dryness, personal hygiene, and avoiding sharing personal items.

 

WHY HOMEOPATHIC MEDICAL REPERTORY

The Homeopathic Medical Repertory by Robin Murphy is a modern, clinically oriented repertory that integrates classical homeopathic principles with contemporary medical understanding. It is alphabetically arranged, making it easy to use, and includes extensive rubrics related to fungal diseases. It allows the physician to work with clinical diagnoses, pathological generals, and complete symptoms, making it especially suitable for conditions like fungal infections where pathology is well defined.

Its inclusion of nosodes, sarcodes, and newer remedies enhances its scope for treating chronic and resistant cases. The repertory’s comprehensive structure enables precise and individualized remedy selection, which is essential in managing recurrent and complicated fungal skin conditions.

 

Objective

Primary Objective:
To manage cases of fungal skin infections using homeopathic treatment based on the Homeopathic Medical Repertory by Robin Murphy.

Secondary Objective:
To study and evaluate various rubrics related to fungal skin infections in Murphy’s repertory.

 

Methodology

This study will be conducted as a case series over a period of 18 months with a sample size of 40 patients. Patients aged 16 years and above diagnosed with dermatophytes, candidiasis, or pityriasis versicolor will be included after informed consent. Immunocompromised patients, systemic fungal infections, and non-fungal skin diseases will be excluded.

Each patient will undergo detailed case-taking followed by repertorization using RADAR software (Murphy Repertory). Individualized homeopathic remedies will be prescribed based on symptom similarity. Follow-ups will be done every 15 days or as required. The Dermatology Life Quality Index (DLQI) will be used before and after treatment to assess improvement.

 
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