Chemotherapy is a medical treatment which aims to inhibit cell proliferation and tumor multiplication, thus avoiding invasion and metastasis via many ways of drug administration such as orally, intravenously, subcutaneously, intramuscularly, or intrathecal.Worldwide approximately 63% of patients diagnosed with cancer receive chemotherapy as a treatment approach which can further increase by 67% by the year 2040.Virtual Reality refers to a particular technological system, which includes a computer capable of providing interactive three-dimensional visualization, a controller for interaction with the animations, a position tracker, and a head-mounted display to deliver the visual output. Virtual reality mainly has 2 types: Immersive VR and Non-Immersive Virtual Reality. Immersive Virtual Reality is done by using head mounted set with help of mobile phone and plays different Audio and Video clip ,VR offers an immersive and interactive environment that fosters a sense of presence and transports individuals to a different reality, potentially reducing anxiety and pain perception.In Close Chain kinematic Exercise, the proximal component of the limb moves throughout the exercise, while the distal part remains stationary , CKC exercises improve overall functional mobility and lower the risk of falls, strengthens muscles, improves neuromuscular control & proprioception, and stabilizing joints and enhancing muscle coordination. So, with the help of the traditional close kinematic chain exercise we add the new Immersive Virtual Reality as treatment approach for relieving the pain and fatigue in patients.