Postoperative sore throat is a common complication following general endotracheal anaesthesia affecting patient’s postoperative comfort and satisfaction

Several pharmacological agents like Dexamethasone Ketamine Dexmedetomidine Magnesium sulphate etc have been tried through nebulization route have been studied with promising results Although Dexmedetomidine nubulisation and Dexmedetomidine in combination with Ketamine nebulisation are routinely used in Anaesthesiology practice there is literature deficit regarding there comparison for prevention of POST This study intends to compare efficacy of Dexmedetomidine nebulisation alone or Dexmedetomidine in combination with Ketamine nebulisation for prevention of POST in adult patients undergoing laparoscopic surgery

80 Patients will be randomized by computer generated randomization number into two groups D and DK with equal number of participants

Allocation concealment will be ensured through the use of sealed opaque envelopes

The patient and the investigator collecting the data will be blinded to the study intervention groups

The following baseline demographic and clinical characteristics will be recorded for all patients in preoperative area before shifting the patient to operating room age sex ASA physical status non invasive Blood Pressure Heart Rate SPO2 as baseline parameter Standard ASA provided NPO guideline will be followed for the study

All patients will undergo a thorough preoperative evaluation one day before surgery A detailed explanation of the study will be provided to each participant and written informed consent will be obtained Adequate fasting status will be confirmed before surgery and all patients will receive standard anti-aspiration prophylaxis

On the day of surgery Patients will be nebulized according to their assigned group as follows

Group D 40 Patients will be nebulized with dexmedetomidine 1 mcg per kg diluted in 4 ml of normal saline over 15 minutes

Group DK 40 Patients will be nebulized with a combination of dexmedetomidine 1mcg per kg and ketamine 0.5mg per kg diluted in 4 ml of normal saline over 15 minutes

In both groups standard anaesthesia management will be done as mentioned below

Upon arrival in the operating room standard American Society of Anesthesiologists ASA monitors will be attached including noninvasive blood pressure pulse oximetry electrocardiography

The patents will be preoxygenated with 100 percentage oxygen Induction will be achieved with intravenous fentanyl 1to2 mcg per kg and propofol  2mg per kg  titrated to the effect of  loss of verbal response and vecuronium 0.1 mg per kg and after securing airway with endotracheal intubation anaesthesia will be maintained with Isoflurane 0.5 to 1 MAC  and O2  and N2O ratio is 40 and 60 ratio Smooth laryngoscopy and intubation lasted less than 15 sec will be performed by same well experienced anaesthesiologist to avoid interobserver bias

Normocapnia will be maintained with controlled mechanical ventilation with endtidal carbondioxide tension values ranging from 30 to 35 mmHg  Euvolemia will be maintained with crystalloid infusion Normothermia will be maintained throughout the surgery with forced air warming device and infusion of warm fluids  Antiemetic in the form of Ondansetron 4mg IV will be given 30 min before end of surgery Gentle extubation of the patient will be done after reversal of neuromuscular blocking agent after completion of the surgery

The following parameters will be recorded in the study CormackLehane grading during laryngoscopy ETT cuff pressure using a cuff manometer and hemodynamic parameters systolic diastolic and mean arterial pressures heart rate and oxygen saturation and sedation at predefined time points during induction laryngoscopy and intubation 1 and 5minutes postintubation and following pneumoperitoneum creation Airway pressure will be noted and keep less than 25 cm H2O after intubation and following intraabdominal gas insufflation The ETT intracuff pressure will be remeasured and documented just before extubation

In the postoperative period sore throat will be assessed and graded using 4 Point scale as per Harding and McVey  at 10 minutes 6 hours 12 hours and 24 hours following extubation Sore throat will be treated according to standard POST treatment protocol Additionally hemodynamic parameters blood pressure heart rate and oxygen saturation will be recorded at extubation at 10 minute and 1 hour 6 hours 12 hours and 24 hours postextubation  Sedation using Ramsay sedation score  will be assessed at 15 minutes after nebulisation 10 minute 1 hour  6 hours after extubation.