Vitiligo is an acquired depigmentation disorder characterized by depigmented lesions resulting from autoimmune destruction of melanocytes. It has a major impact on the quality of life of patients due to low self-esteem esteem and social isolation.

Medical treatments like topical steroids, calcineurin inhibitors, and phototherapy are tried during the active stage of the disease, but in most cases, optimal results are not achieved. Lesions in acral and non hairy regions are often resistant to treatment. Surgical treatment is helpful in such resistant areas and in residual lesions.

Melanocytes can be introduced by cellular or tissue grafts. Surgical treatment  including tissue graft (punch, blister and split skin grafts) and cellular suspension (of cultured or non cultured cells melanocyte keratinocyte suspension) are used to treat stable vitiligo which are refractory to medical treatment. Melanocyte keratinocyte suspension has become popular surgical modality of vitiligo treatment as it can repigment maximum area compared to tissue grafts. However, loss of pigmentation and relapse occurs in few patients.

While vitiligo surgery provides good results in majority of patients, some lesions fail to repigment or lose achieved pigmentation. It usually manifests as a depigmented halo around the treated area(perilesional halo/achromic fissure). This is supposed to be due to cytotoxic CD8+ T cells in the perilesional skin. Cyclosporine is an immunomodulator that acts on Tcells .In this study we are going to compare the outcome after NCES in terms of extent and quality of repigmentation in two groups with and without cyclosporine.